Ligandrol (LGD-4033) Guide: Results, Dosage, Cycles & More!

Ligandrol, otherwise known as LGD-4033, is a selective androgen receptor modulator (SARM) that has highly powerful muscle-building effects.

In fact, many bodybuilders can put on pounds of lean muscle in just 8-12 weeks from a single cycle of Ligandrol, or maybe even more.

What does the clinical evidence say about Ligandrol, however? Is it safe? Can you use it for bodybuilding? If so, how Effective is it?

In this article, we will present you with evidence-based claims, and show you the facts, so you can make up your mind about this SARM.

What is Ligandrol (LGD-4033)?

ligandrol chemical structure

Similar to Ostarine, RAD 140, and Cardarine, Ligandrol, otherwise known as LGD4033, is a selective androgen receptor modulator (SARM).

Selective androgen receptor modulators, or SARMs for short, are a relatively new and experimental class of research chemicals, which show extraordinary promise to help users rapidly put on pounds of lean muscle.

While it was first discovered by Ligand Pharmaceuticals, LGD-4033 is currently undergoing research through Viking Therapeutics. [R]

According to research thus far, Ligandrol presents extraordinary promise, and is arguably one of the most androgenic SARMs to date.

The main goal of Ligandrol is to assist users in building muscle, and is particularly useful when on a dirty bulk or clean bulk.

Overview of LGD 4033 Pros & Cons

Before we get into the clinical studies, results, dosages, and side effects of Ligandrol, we’d like to first present a brief overview of its pros and cons.

Benefits Include:

  • Increased Muscle Mass Gain
  • Great SARM For Bulking
  • Increased Bone Density
  • Enhanced Recovery Time
  • Improved Fat Loss Speed

Potential Drawbacks Include:

  • May Have Long-Term Side Effects
  • Not Approved For Human Use (Yet)
  • Temporary Testosterone Suppression
  • Decreased HDL (Good Cholesterol)

One of the biggest advantages of Ligandrol is its ability to be used as a bulking compound, to help users improve their overall body mass.

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In fact, Ligandrol is currently the best SARM to take when it comes to raw muscle gains. While it may not be as good as a SARM like Ostarine or RAD 140 for cutting, it excels at helping users get big.

Most of the research literature suggests that Ligandrol is relatively safe when taken within the recommended dosages, however more studies need to be done regarding the long-term effects of LGD 4033.

Legality of LGD-4033

According to the World Anti-Doping Agency (WADA), athletes are strictly prohibited from using Ligandrol and other SARMs. [R]

The United States Anti Doping Agency, or the USADA for short, has also outlawed athletes from using SARMs during competitions. Many high profile cases, such as that of Jim Wallhead, have emphasized this.

That being said, SARMs are completely legal.

In other words, if you wanted to, you could buy SARMs online right now—we just recommend you get them through a reputable vendor, though.

This is why many people are choosing to take SARMs as a way to get stronger, help their recovery, gain muscle mass, and get in better shape.

Where to Buy Ligandrol

If you’re just skimming this article and want a high quality source to purchase Ligandrol from, we recommend the Ligandrol from Science Bio.

Every batch of their SARMs are 3rd party verified, so you know that they’re at least 99% pure, verified by an independent laboratory.

When ordering SARMs online, you need to be very careful—only get them from a reputable vendor, as many vendors sell fake SARMs laced with dangerous prohormones, or even worse.

How Does Ligandrol Work?

sarms androgen receptors

Similar to other selective androgen receptor modulators (SARMs), Ligandrol works by binding to androgen receptors in the body shortly after use. [R]

SARMs such as Ligandrol have a high affinity for skeletal muscle androgen receptors, meaning they tend to give steroid-like effects, without causing the common heart and prostate-related side effects of steroids.

LGD 4033 is highly bio-available, meaning it doesn’t need to be injected like steroids—many test subjects simply choose to take it orally.

Upon ingestion, Ligandrol quickly binds to androgen receptors, and begins exerting an anabolic effect, allowing the user to rapidly build muscle.

Ligandrol vs. Steroids

Both steroids and SARMs have similar effects. They both shred fat, increase strength, help users gain muscle, and can provide incredible results.

That being said, there are some key differences between the two, and how they affect your body. What makes SARMs unique is that they have a high affinity for skeletal muscle androgen receptors.

With SARMs, for example, users won’t experience as many of the negative prostate-related side effects that steroids might cause, due to the selective nature of SARMs. [R]

However, the results that you can get from an LGD 4033 cycle, from taking, say, 10 mg per day, are comparable to a low dose cycle of steroids.

If you want to see SARMs before and after results from multiple different SARMs, we’ve already documented them in that article there (read it).

The benefit of SARMs is that they’re completely legal to purchase, and are more selective in nature. The drawback is that they may be more liver-toxic than an injectable steroid cycle.

Regardless, most studies suggest that SARMs are well-tolerated when taken within the recommended dose range, so plenty of amateur bodybuilders are choosing to take SARMs over steroids.

Benefits of LGD-4033

lgd 4033 benefits

The most obvious benefit of Ligandrol (LGD 4033) is building muscle. Many users experience gains of 10 pounds or more of muscle while on cycle.

While more research must certainly be done on the long term effects, there are still many clinical applications for taking LGD 4033 in the short term.

Here are some benefits of Ligandrol:

  • Rapid Muscle Growth
  • Enhanced Athleticism
  • Increased Strength
  • Great For Bulking
  • Minimal Side Effects

In our experience, Ligandrol is one of the best SARMs for bulking up, due to its ability to help users pack on slabs of muscle mass extremely quickly.

Most people take Ligandrol for body building, due to its potent anabolic effects—however let’s explain some of the other benefits, as well.

Rapid Muscle Growth

As stated, the biggest and most obvious benefit of LGD-4033 is rapid muscle growth—many athletes and bodybuilders use Ligandrol for this reason.

Researchers at the Boston Medical Center’s Section of Endocrinology, for example, stated that Ligandrol (LGD 4033) increased lean muscle mass in users, without many side effects, and was generally well-tolerated. [R]

Most studies on LGD 4033 have found that it leads to a dose-dependent increase in muscle mass in users, even with very low dosages.

It’s also important to note that a SARM like Ligandrol is probably the best SARM for bulking, although many people find that the muscle gains aren’t as dry as those from a compound like Ostarine, for example.

Enhanced Athleticism

It’s clear that Ligandrol gives professional athletes an advantage, particularly because it increases lean muscle mass significantly in users.

Taking a SARM like LGD 4033 gives athletes a clear advantage with better recovery, faster fat loss, and quicker strength gains—which is why it’s so popular amongst body builders.

In fact, the research to suggest that LGD-4033 is highly anabolic is so strong, that the USADA has acknowledged it as being performance-enhancing. [R]

Currently, LGD 4033 (and all other SARMs) are banned by the World Anti-Doping Association, although they are still legal to buy and sell in the US.

Increased Strength

While there is minimal research testing Ligandrol for body building, there is an enormous amount of anecdotal evidence from recreational users.

Many posters on Reddit and various body building forums have reported strength increases as high as 35% from a single cycle of Ligandrol.

Other users also report that stacking LGD 4033 with other SARMs, or even with a steroid like testosterone enanthate, can enhance recovery, fat loss, and strength gains even more.

Much of your LGD 4033 results will depend on many factors of course, however it’s clear that Ligandrol has many benefits, with increased strength and muscle mass gains being the primary ones.

Ligandrol Dosage & Cycles

ligandrol clinical study

While the previously cited study demonstrated that Ligandrol is safe in dosages as high as 22 milligrams, most users start by taking less.

For men, the most common recreational dosage is 10-20mg per day, and for women, the most common recreational dosage is 5-10mg per day.

You will see results from LGD-4033 on a dosage as low as 0.1mg, but most male recreational users prefer to start by taking 10mg per day.

Ligandrol can also be stacked with other SARMs for added benefit, depending on whether you want to do a bulking cycle or a cutting cycle of SARMs.

For a bulking cycle, LGD4033 is often stacked with MK-677 or RAD 140, and for cutting, Ligandrol pairs well with Cardarine or S4.

Ligandrol Dose For Bodybuilding

The standard beginner’s dosage of Ligandrol is 10 mg per day, which is roughly one full dropper per day of the Ligandrol from Science Bio.

Using this dosage, users can expect to put on 10-15 pounds of muscle mass in 8-12 weeks, although it may not be entirely lean muscle mass (much of it may simply be water retention).

Here’s a guide to the best LGD 4033 dosages:

  • Beginner Dosage: 10mg/Day
  • Intermediate Dosage: 15mg/day
  • Advanced Dosage: 20mg/day

Some people, particularly women, choose to use even less of this SARM, taking dosages as low as 5mg per day, to minimize potential side effects.

While studies have shown Ligandrol to be relatively safe and well-tolerated, no clinical study has given test subjects more than 22 mg per day.

How to Cycle LGD4033

It’s important to cycle SARMs on and off, and Ligandrol is no exception. It’s best for your health if you wait at least 4-8 weeks between cycles.

It’s important to give your body time to recover from the effects of SARMs on your HPG axis, allowing your natural testosterone production to go back to normal levels.

A typical LGD 4033 cycle might look like this:

  • Weeks 1-8: Take 10mg Ligandrol Daily
  • Weeks 9-12: Follow With PCT
  • Weeks 13-20: Allow Your Body to Recover

Most people take at least 4-8 weeks off between cycles, otherwise your testosterone production will stay suppressed from constant SARMs use.

Ligandrol (LGD 4033) Results

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Out of all the SARMs currently for sale on the market right now, Ligandrol is arguably the best for increasing muscle mass, milligram for milligram. [R]

Users who take LGD 4033 can expect to get very fast results, gaining as much as 10-15 pounds of muscle in as little as 8-12 weeks.

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In fact, there’s many reports of men transforming their bodies and getting phenomenal results in just a matter of weeks from Ligandrol—something that would normally only be possible when using anabolic steroids.

In a clinical setting, a small 1 mg dosage of Ligandrol (LGD-4033) per day led to an average of 2.67 pounds gained in 12 weeks.

Assuming that the dosage scales linearly, bodybuilders could easily gain 10-15 pounds of muscle mass on a standard dosage of Ligandrol.

LGD-4033 Side Effects

muscular man on ligandrol

While Ligandrol has been demonstrated to be well tolerated in most users, that doesn’t mean there won’t be some minor (or more serious) side effects.

The most common and obvious side effect of taking LGD 4033, is temporary testosterone suppression while on cycle. This is why a good SARMs PCT is important.

Common side effects of LGD4033 may include:

  • Reduced HDL Cholesterol
  • Mild Testosterone Suppression
  • Water Retention
  • Increased Stress on The Liver
  • Mild Gynecomastia

One of the most common side effects of Ligandrol on the body is a dose-dependent decrease in the body’s natural testosterone production.

This is why many body builders keep an aromatase inhibitor on hand during their Ligandrol cycles, in case estrogen levels get out of balance.

This being said, many of these side effects can be mitigated by getting regular blood work done, and by taking the appropriate on-cycle drugs.

If your family has a history of high cholesterol, you may want watch your HDL and LDL levels while on cycle—taking Lipitor may help with this.

Thankfully, studies have shown that Ligandrol (LGD 4033) does not alter hemoglobin levels, liver enzymes, or heart rate, so it is still relatively safe.


In conclusion, Ligandrol, otherwise known as LGD-4033, is a potent SARM which has been shown to help users rapidly increase muscle mass.

Much more research must be conducted on the long-term side effects of Ligandrol, but preliminary research suggests it’s very well tolerated.

If you do decide to purchase Ligandrol for research purposes, the highest quality source available is currently Science Bio.

We hope this article was informative and helpful, but if you believe we left any important information out, please leave a comment below!

Frequently Asked Questions
❓ Is Ligandrol Good For Bodybuilding?

Ligandrol is very good for bodybuilding. In fact, it's one of the best SARMs when it comes to doing a dirty bulk, or a "wet bulk." Many bodybuilders love using Ligandrol (LGD-4033) for gaining mass during bulking season, and then follow it up with a cut.

❓ What Does Ligandrol Do To Your Body?

Ligandrol increases strength and muscle mass in the body by binding to androgen receptors in your skeletal muscles. This way, it signals your biceps, triceps, legs, pecs, and other muscles to start growing faster, and recovering quicker.

❓ What is Ligandrol Used For?

Ligandrol (LGD 4033) is typically used for gaining mass, and is often used during an off season bulk for this reason. Users often report gaining upwards of 20 pounds on a cycle, even while losing fat at the same time. In short, Ligandrol is a favorite for bulking up.

❓ What's The Best Ligandrol Dosage to Take?

While the Ligandrol dosages vary depending on users, most agree that the sweet spot for taking Ligandrol is between 10-20mg per day, although some experienced bodybuilders may take more. A great dosage for beginners to start at is 15mg/day, taken first thing in the morning.

❓ Does Ligandrol Require A PCT?

It's generally recommended that you follow your Ligandrol cycle up with a post cycle therapy (PCT), as studies have shown that Ligandrol is fairly suppressive to testosterone levels. Some people opt out of taking a PCT, but most medical professionals agree that a PCT is best.

Nanotech Project Team

The Nanotech Project team is committed to providing the most accurate and up-to-date information about anabolics, nootropics, and bio-hacking as a whole.

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