Cardarine Guide: Can GW-501516 Really 2x Your Endurance?
Cardarine, otherwise known as its research name GW501516, is a research chemical that has garnered the eye of many athletes around the globe.
While it’s often lumped in with SARMs, Cardarine isn’t technically a SARM—it’s a PPARδ receptor agonist, developed to improve cardiovascular health in those suffering from diseases.
Recently however, many bodybuilders and athletes have been using Cardarine to shred fat and enhance endurance—does it work, though?
In this article, we’ll cover the results, dosage, cycle guidelines, and take a look at what the clinical research has to say about Cardarine so far.
What is Cardarine? (GW501516)
Cardarine is often placed in the group of SARMs, although this isn’t entirely accurate—while Cardarine may be similar to SARMs, it is not a SARM.
Cardarine, sometimes known by its research chemical name GW-501516, is a peroxisome proliferator-activated receptor delta agonist that was initially developed to help treat metabolic and cardiovascular diseases. [R]
Recreational users soon discovered that Cardarine could also be used to drastically increase endurance and accelerate fat loss, though.
In fact, according to most cycle logs and anecdotal evidence, Cardarine can be used as a powerful cutting agent, to lose fat rapidly, and to seriously improve endurance levels.
How Does Cardarine Work?
Shortly after ingestion, Cardarine works by binding to the PPAR Delta receptor, and signals the liver to draw energy from fatty acids. [R]
Typically, your body draws energy from blood sugars (glucose), however by switching the preferred source to fatty acids, fat loss is accelerated.
In fact, it isn’t uncommon for people using Cardarine for bodybuilding to report losing over 10-15 pounds from one 8-12 week cycle.
Unfortunately however, Ligand Pharmaceuticals, the same company that created Ligandrol, abandoned Cardarine research in 2007, so there isn’t very much clinical data regarding this drug’s fat loss effects.
While Cardarine hasn’t technically been approved for human usage, many of bodybuilders report losing large amounts of fat on Cardarine cycles.
In fact, it isn’t uncommon for users to report losing 10-15 pounds of fat from a 12 week cycle of Cardarine, even at a relatively low dose such as 10 mg.
Here are some benefits of Cardarine (GW 501516):
- Accelerated Fat Loss
- Enhanced Endurance
- Great Cutting Agent
- Improved Blood Lipids
The most impressive benefit of Cardarine, is its ability to increase endurance in users. In fact, one study found that lab rats that took Cardarine increased endurance by over 200% more than placebo. [R]
Many users experience phenomenal results from Cardarine, particularly bodybuilders trying to decrease their body fat percentages and get lean.
The Cardarine results pictured above are from a video by Greg Doucette, who is an International Federation of Bodybuilding & Fitness Pro.
“It was crazy. I was so much faster,” he said about using Cardarine in a biking race. “I can’t point out how much improvement that it made.”
He also added that it helped him in the gym, too. “My endurance, set after set after set after set was easy,” he said. “I could’ve kept going.”
Many other users experience similar effects while on Cardarine, reporting enhanced performance, faster fat loss, and insane endurance effects.
Dosage & Cycle Guidelines
Clinical trials conducted on humans used Cardarine dosages ranging from 2.5 mg to 10 mg per day, although some people have used up to 20 mg.
Here are the Cardarine dosage guidelines:
- Beginner: 5 mg per day
- Intermediate: 10 mg per day
- Advanced: 20 mg per day
For example, an intermediate dosage of Cardarine would be 10 mg per day, or half a dropper of the Cardarine (GW-501516) from Science Bio.
The effects of Cardarine are dose-dependent, meaning that if you take a higher dosage of GW-501516, you will experience more fat loss, endurance, and energy, as well as potentially more side effects.
Bulking & Cutting Stacks
Some users take multiple SARMs at once, which allows them to experience even more muscle growth, fat loss, and enhanced athletic performance.
Cardarine (GW501516) is generally best suited for a cutting stack, as it allows users to burn fat rapidly, and enhances endurance.
|Sample Bulking Stack||Sample Cutting Stack|
|Cardarine – 10 mg per day||Cardarine – 20 mg per day|
|Ligandrol – 20 mg per day||Ostarine – 25 mg per day|
|YK11 – 10 mg per day||Andarine – 50 mg per day|
While Cardarine is generally considered a good SARM for cutting, it can also be used to do a lean bulk, as it prevents fat gain even when in a minor caloric surplus, according to many cycle logs and user reports.
Potential Side Effects
According to the Australian Department of Health, as well as clinical research, there are no known side effects of taking Cardarine. [R]
While there are no known short term side effects of GW-501516 use in humans, more research should be done on the long term effects.
One common question people have relates to a study which found that Cardarine caused cancer growth to develop in organs of lab rats.
It has been noted, however, that the rats in this study were given Cardarine for roughly 2/3 of their life straight (with no breaks).
With this in mind, the evidence that Cardarine could cause cancer in humans is shaky at best—no bodybuilder is going to dose Cardarine daily for two thirds of his life (roughly 50 years straight).
In conclusion, Cardarine is often grouped together with SARMs, although it is technically not a SARM—but rather a PPAR Delta receptor agonist.
That being said, many athletes take Cardarine along with other SARMs, and experience huge endurance boosts, as well as accelerated fat loss.
If you want to purchase legitimate Cardarine (GW-501516), we recommend getting it from a 3rd party tested source, like Science Bio.
Every batch of their research chemicals and SARMs is 3rd party verified for purity, and if you use the code “nanotech” you’ll get 10% off your order.