Cardarine Guide: Can GW-501516 Really 2x Your Endurance?

Cardarine, otherwise known as its research name GW501516, is a research chemical that has garnered the eye of many athletes around the globe.

While it’s often lumped in with SARMs, Cardarine isn’t technically a SARM—it’s a PPARδ receptor agonist, developed to improve cardiovascular health in those suffering from diseases.

Recently however, many bodybuilders and athletes have been using Cardarine to shred fat and enhance endurance—does it work, though?

In this article, we’ll cover the results, dosage, cycle guidelines, and take a look at what the clinical research has to say about Cardarine so far.

What is Cardarine? (GW501516)

Cardarine is often placed in the group of SARMs, although this isn’t entirely accurate—while Cardarine may be similar to SARMs, it is not a SARM.

Cardarine, sometimes known by its research chemical name GW-501516, is a peroxisome proliferator-activated receptor delta agonist that was initially developed to help treat metabolic and cardiovascular diseases. [R]

Buy USA Made Cardarine Here!

Recreational users soon discovered that Cardarine could also be used to drastically increase endurance and accelerate fat loss, though.

In fact, according to most cycle logs and anecdotal evidence, Cardarine can be used as a powerful cutting agent, to lose fat rapidly, and to seriously improve endurance levels.

Overview of Pros & Cons

Before we look at the various dosages, cycles, stacks, and effects on the body that Cardarine has, let’s first give a quick overview of it.

Potential benefits of Cardarine:

  • Enhance Muscle Endurance
  • Accelerate Body Fat Loss
  • Increase Energy Levels
  • Promote Lean Muscle Gain
  • Improve Insulin Sensitivity
  • Healthier Blood Lipid Profile

Potential drawbacks include:

  • Not Entirely Risk Free
  • More Research Should Be Done
  • Increased Rate of Cell Death
  • High Dosages May Increase Cancer Risk

The biggest concern many people have with Cardarine is its potential to cause cancer, but as we’ll explore later in this article, the study which came to this conclusion gave lab mice an incredibly high dosage that almost no human would ever take, for a very long period of time. [R]

All in all, Cardarine is a fascinating research drug which body builders can use to keep muscle on a cut, promote accelerated fat loss, and much more.

How to Get Cardarine

Tons of bodybuilders love using this PPAR delta receptor agonist to enhance lean muscle growth, increase energy levels, and improve recovery.

So, if you’re looking to get some legitimate Cardarine for yourself, then we recommend you only do it through a reputable vendor like Science Bio.

Every batch of SARMs that they sell is 3rd party tested for purity, and if you use the code “nanotech” you’ll get 10% off any products you want to buy.

How Does Cardarine Work?

Shortly after ingestion, Cardarine works by binding to the PPAR Delta receptor, and signals the liver to draw energy from fatty acids. [R]

Typically, your body draws energy from blood sugars (glucose), however by switching the preferred source to fatty acids, fat loss is accelerated.

In fact, it isn’t uncommon for people using Cardarine for bodybuilding to report losing over 10-15 pounds from one 8-12 week cycle.

Unfortunately however, Ligand Pharmaceuticals, the same company that created Ligandrol, abandoned Cardarine research in 2007, so there isn’t very much clinical data regarding this drug’s fat loss effects.

Cardarine vs. SARMs

One of the biggest misconceptions that a lot of people have, is that Cardarine is somehow a SARM—this is actually not the case.

Rather, it is something known as a PPARδ receptor agonist, which is a class of products currently under research for their potential cardiovascular health benefits.

That being said, Cardarine is often sold alongside SARMs, and many body builders find that stacking it with SARMs such as RAD 140 can help accelerate fat loss, and makes for a great cutting cycle.

Cardarine Benefits

While Cardarine hasn’t technically been approved for human usage, many of bodybuilders report losing large amounts of fat on Cardarine cycles.

In fact, it isn’t uncommon for users to report losing 10-15 pounds of fat from a 12 week cycle of Cardarine, even at a relatively low dose such as 10 mg.

Here are some benefits of Cardarine (GW 501516):

  • Accelerated Fat Loss
  • Enhanced Endurance
  • Great Cutting Agent
  • Improved Blood Lipids

The most impressive benefit of Cardarine, is its ability to increase endurance in users. In fact, one study found that lab rats that took Cardarine increased endurance by over 200% more than placebo. [R]

Cardarine Results

cardarine results
Copyright @ Greg Doucette

Many users experience phenomenal results from Cardarine, particularly bodybuilders trying to decrease their body fat percentages and get lean.

The Cardarine results pictured above are from a video by Greg Doucette, who is an International Federation of Bodybuilding & Fitness Pro.

Buy USA Made Cardarine Here!

“It was crazy. I was so much faster,” he said about using Cardarine in a biking race. “I can’t point out how much improvement that it made.”

He also added that it helped him in the gym, too. “My endurance, set after set after set after set was easy,” he said. “I could’ve kept going.”

Many other users experience similar effects while on Cardarine, reporting enhanced performance, faster fat loss, and insane endurance effects.

Cardarine Dosage & Cycles

A Cardarine Vial From Science Bio

Clinical trials conducted on humans used Cardarine dosages ranging from 2.5 mg to 10 mg per day, although some people have used up to 20 mg.

Here are the Cardarine dosage guidelines:

  • Beginner: 5 mg per day
  • Intermediate: 10 mg per day
  • Advanced: 20 mg per day

For example, an intermediate dosage of Cardarine would be 10 mg per day, or half a dropper of the Cardarine (GW-501516) from Science Bio.

The effects of Cardarine are dose-dependent, meaning that if you take a higher dosage of GW-501516, you will experience more fat loss, endurance, and energy, as well as potentially more side effects.

Cardarine Bulking & Cutting Stacks

Some users take multiple SARMs at once, which allows them to experience even more muscle growth, fat loss, and enhanced athletic performance.

Cardarine (GW501516) is generally best suited for a cutting stack, as it allows users to burn fat rapidly, and enhances endurance.

Sample Bulking StackSample Cutting Stack
Cardarine – 10 mg per dayCardarine – 20 mg per day
Ligandrol – 20 mg per dayOstarine – 25 mg per day
YK11 – 10 mg per dayAndarine – 50 mg per day
Sample Cardarine Bulking & Cutting Stacks

While Cardarine is generally considered a good SARM for cutting, it can also be used to do a lean bulk, as it prevents fat gain even when in a minor caloric surplus, according to many cycle logs and user reports.

Cardarine Side Effects

According to the Australian Department of Health, as well as clinical research, there are no known side effects of taking Cardarine. [R]

While there are no known short term side effects of GW-501516 use in humans, more research should be done on the long term effects.

One common question people have relates to a study which found that Cardarine caused cancer growth to develop in organs of lab rats.

It has been noted, however, that the rats in this study were given this PPARδ receptor for roughly 2/3 of their life straight (with no breaks).

With this in mind, the evidence that Cardarine could cause cancer in humans is shaky at best—no bodybuilder is going to dose Cardarine daily for two thirds of his life (roughly 50 years straight).

Where to Buy Cardarine

sarms from science bio

If you are like many other body builders, and want to get the best results in the gym that you possibly can, you’re probably wanting to try Cardarine.

If you do decide to try Cardarine, be sure to get it from a high quality source, like the ones we outlined in our SARMs for Sale article.

It helps to make sure the company you buy from has good 3rd party verification protocols, otherwise you may get an impure substance.

Our top recommendation here at Nanotech Project is Science Bio. All of their products are tested for purity, and if you use the code “nanotech” you’ll get 10% off any product you want.


In conclusion, Cardarine is often grouped together with SARMs, although it is technically not a SARM—but rather a PPARδ receptor agonist.

That being said, many athletes take Cardarine along with other SARMs, and experience huge endurance boosts, as well as accelerated fat loss.

If you want to purchase legitimate research chemicals and drugs, we recommend getting it from a 3rd party tested source, like Science Bio.

Every batch of their research chemicals and SARMs is 3rd party verified for purity, and if you use the code “nanotech” you’ll get 10% off your order.

Frequently Asked Questions
❓ Is Cardarine Good For Bodybuilding?

Cardarine (GW-501516) is a phenomenally effective compound that bodybuilders love using to burn fat and enhance endurance. It's especially powerful when it comes to increasing your cardiovascular endurance, which is why many marathon runners use it.

❓ How Does Cardarine Work in the Body?

Cardarine is a PPAR Delta Receptor Agonist, meaning that shortly after ingestion, it binds to PPAR Delta Receptors and activates them. This signals your body to switch its main fuel source from carbohydrates over to fat (ketosis), which enhances your metabolic rate greatly.

❓ What is Cardarine Used For?

Cardarine (GW 501516) is typically used for burning fat and increasing your endurance. In fact, many people report slicing up to 2 minutes off their mile times from a simple Cardarine cycle. When it comes to enhancing endurance, Cardarine reigns supreme.

❓ What's The Best Cardarine Dosage to Take?

While the dosages will vary depending on your gender, weight, and goals, most people agree that the best Cardarine dosage is going to be around 10-20mg per day, although some users have taken far more and reported little to no side effects.

❓ Does Cardarine Require A PCT?

Since Cardarine is not a SARM, but rather a PPAR Delta Receptor Agonist, it does not require a PCT (post cycle therapy). If you take Cardarine with SARMs however, for a cycle or stack, then you should still follow the common PCT protocol outlined on this website.

Nanotech Project Team

The Nanotech Project team is committed to providing the most accurate and up-to-date information about anabolics, nootropics, and bio-hacking as a whole.

Click Here to Leave a Comment Below 0 comments