Lately, there has been uproar about a nootropic named Sunifiram. The nootropic has been creating waves, mainly because of its cognitive enhancement effects. Sunifiram is also believed to boost memory, enhance learning skills, and improve mood.
If you find this nootropic interesting and want to learn more about it, then keep reading the blog. In this blog, we will give detailed information on what Sunifiram is and how it works. What are the benefits and side effects associated with it?
Moreover, we’ll discuss Sunifiram dosage and its top vendors so that you can make an informed decision about its usage and sourcing.
What Is Sunifiram
Sunifiram also known as DM-235 is a synthetic derivative of Piracetam. Research has found that Sunifiram is four times more potent than Piracetam when it comes to cognitive enhancement, even though both nootropics share the same low toxicity profile. [1]
Studies have shown that Sunifiram might prevent cognitive deficits at very low doses. This shouldn’t come as a surprise given that this nootropic is highly powerful, about 1,000 times more potent than the most active piracetam-like compounds. [2]
Studies have also shown that it didn’t impair motor functions and users continued to perform everyday tasks without needing any assistance. [2]
Despite showcasing so much potential, Sunifiram hasn’t attracted much clinical research. The lack of human trials is the reason why it’s still an experimental drug.
How Does Sunifiram Work?
Sunifiram works primarily by enhancing neurotransmitter activity in the brain. This ampakine crosses the blood-brain barrier to trigger glutamate receptors in the brain and stimulate the release of acetylcholine (aka the learning neurotransmitter). The result of these processes is improved memory and learning.
It may also work by activating AMPA and NMDA receptors. AMPA receptors are responsible for sending messages throughout the central nervous system.
They are a type of glutamate receptor that is necessary for synaptic transmission and plasticity, both of which are important for learning and memory. That’s because it was found to reverse the effects of several drugs that suppressed AMPA activity. [3]
Potential Benefits of Sunifiram
Here are the potential benefits associated with sunifiram :
- Accelerate Learning
- Improve Focus and Memory
- Enhance Focus
- Increase Libido
1. Accelerate Learning
Research has shown that Sunifiram stimulates the release and production of acetylcholine in the brain. High acetylcholine levels have been associated with improved brain function, enhanced memory, and better mental health. [4]
The utility of acetylcholine isn’t limited to improved memory only. This neurotransmitter performs various other important functions. It prevents the imbalances in acetylcholine levels, which, if not addressed, might lead to Alzheimer’s disease, Parkinson’s disease, and liver disease. [4]
2. Improve Focus and Memory
Multiple users report that taking Sunifiram has boosted their focus. This, they claim, has helped them get rid of brain fog and made them more productive at work. The reason why you may want to believe in such anecdotal evidence is that scientific evidence might back it.
One study has found that acetylcholine enhances attentional focus. It achieves this objective by modulating neural activity in the sensor regions of the brain. These regions are responsible for regulating attention span. [5]
3. Enhance Mood
Sunifiram increases your energy levels and boosts your mood by enhancing dopamine and serotonin levels. [6] By enhancing the function of these systems, Sunifiram might have a mood-lifting effect.
4. Increase Libido
Research has shown that high-stress levels lead to low libido by increasing blood pressure, heart rate, and breathing rate. Sunifiram, by elevating your mood, may help regulate these vital signs, potentially improving libido. [7]
Sunifiram Side Effects
There are a few reports of Sunifiram users experiencing mild side effects including:
- Headaches
- Insomnia
- Stuffy Nose
- Increased Perspiration
Sunifiram Dosage
Keep in mind that Sunifiram has been proven to be four times more potent than Piracetam. It’s more potent than other nootropics on the market too. That’s probably why many users claim that taking it in very small doses will deliver the desired effects.
Having said that, it is not easy to find a legitimate recommended dosage. The fact that the FDA hasn’t approved it (yet) prevents doctors from prescribing it, and we’ve come across very few clinical trials that could give us a clue on recommended Sunifiram dosage.
- Based on user experience, up to 10 mg, three times a day, will deliver the desired effects.
- To ensure your safety and well-being, try to start with the smallest (5 mg) dose.
You can explore our guide on compounds like Methylene Blue and Adamax.
Where to Buy Sunifiram
Now it is time to talk about some highly authentic and genuine vendors that offer you Sunifiram and various other products at flexible rates. Here is the list of them:
| Vendors | Price Range | Quality Assurance | Verdict |
| Purerawz | $32.18 | Offers Certificates of Analysis (COA) for each batch, ensuring product purity and quality. | Trusted and well-known in the nootropic community. Excellent customer feedback and reviews. |
| BC9.co | $42.96–$65.69 | Provides COAs for Sunifiram batches. Ensures products are tested for potency and purity by certified labs to meet high standards. | An established online vendor with a reputation for providing premium-quality nootropics. |
| RCDbio.co | $44.99 | Committed to quality with third-party lab testing and COAs. Tests for identity, purity, and potency to ensure products are safe and effective. | Known for reliability and customer satisfaction. They maintain a good reputation in the supplement community. |
Disclaimer
The information provided is for informational purposes only and should not be considered medical advice. Readers should consult with a healthcare professional before using Sunifiram or any other supplement
On the Whole
Sunifiram is considered a potent nootropic. Various studies have found this supplement to be four times more potent than Piracetam.
However, despite being incredibly potent, this substance’s toxicity profile is similar to that of Piracetam. This means that it’s not only powerful but also safe.
You can thus count on Sunifiram to deliver the benefits mentioned above – improved memory, enhanced learning, heightened sexual drive – without endangering your health.
References
- Romanelli, M. N., Galeotti, N., Ghelardini, C., Manetti, D., Martini, E., & Gualtieri, F. (2006). Pharmacological Characterization of DM232 (Unifiram) and DM235 (Sunifiram), New Potent Cognition Enhancers. CNS Drug Reviews, 12(1), 39–52. https://doi.org/10.1111/j.1527-3458.2006.00039.x
- C., G., N., G., F., G., M., R., C., B., E., B., & A., B. (2002). DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer. Naunyn-Schmiedeberg’s Archives of Pharmacology, 365(6), 419–426. https://doi.org/10.1007/s00210-002-0577-3
- Galeotti, N., Ghelardini, C., Pittaluga, A., Pugliese, A. M., Bartolini, A., Manetti, D., Romanelli, M. N., & Gualtieri, F. (2003). AMPA-receptor activation is involved in the antiamnesic effect of DM�232 (unifiram) and DM�235 (sunifiram). Naunyn-Schmiedeberg’s Archives of Pharmacology, 368(6), 538–545. https://doi.org/10.1007/s00210-003-0812-6
- Berry, J. (2019, October 11). Acetylcholine: What it is, function, and links with health. Www.medicalnewstoday.com. https://www.medicalnewstoday.com/articles/326638
- Dasilva, M., Brandt, C., Gotthardt, S., Gieselmann, M. A., Distler, C., & Thiele, A. (2019). Cell class-specific modulation of attentional signals by acetylcholine in macaque frontal eye field. Proceedings of the National Academy of Sciences, 116(40), 20180–20189. https://doi.org/10.1073/pnas.1905413116
- Herman, J. P., McKlveen, J. M., Ghosal, S., Kopp, B., Wulsin, A., Makinson, R., Scheimann, J., & Myers, B. (2016). Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response. Comprehensive Physiology, 6(2), 603–621. https://doi.org/10.1002/cphy.c150015
- Romanelli, M. N., Galeotti, N., Ghelardini, C., Manetti, D., Martini, E., & Gualtieri, F. (2006). Pharmacological Characterization of DM232 (Unifiram) and DM235 (Sunifiram), New Potent Cognition Enhancers. CNS Drug Reviews, 12(1), 39–52. https://doi.org/10.1111/j.1527-3458.2006.00039.x
