Sunifiram Review: Benefits, Dosage, & More (2021 Guide)
In this Sunifiram review, you’ll get to know everything about the safety and effectiveness of this powerful cognition enhancer.
We’ll also discuss whether this nootropic has what it takes to boost your memory, enhance your learning powers, and elevate your mood.
Plus, we’ll look at scientific evidence to decide whether this supplement is actually four times more potent than Piracetam, both of which work similarly.
All in all, by the time you reach this article’s end, you’ll have enough information at your disposal to decide whether Sunifiram is the right nootropic for your needs.
What Is Sunifiram?
Sunifiram is a synthetic derivative of Piracetam. Both of them belong to the racetam class of drugs. Researchers have found that Sunifiram is four times more potent than Piracetam, even though both nootropics share the same low toxicity profile. [R]
Animal studies have shown that Sunifiram could prevent cognitive deficits at very low doses. This shouldn’t come as a surprise given that this nootropic is highly powerful, about 1,000 times more potent than the most active piracetam-like compounds. [R]
Despite being extremely powerful, this nootropic is safe to use. Preliminary animal studies have shown that it didn’t impair motor functions even at the highest effective doses. Users continued to perform everyday tasks without needing any assistance. [R]
Despite showcasing so much potential, Sunifiram hasn’t attracted much clinical research. The lack of human trials is the reason why it’s still an experimental drug. The FDA hasn’t approved it for use in human medicine, though it’s legal to buy and use Sunifiram in the US.
Overview of Benefits & Effects
In a moment, we’ll turn our attention to what researchers have to say about this powerful nootropic. But before that, here’s a quick overview of its benefits and adverse effects.
- Improves Memory And Learning
- Elevates Focus And Attention Spans
- Boosts Your Mood And Energy Levels
- Contributes To Higher Sex Drive/Libido
- Can Cause Headaches & Insomnia
Both the side effects could be due to high Sunifiram dosage. They may also be due to this nootropic’s mild stimulant effects.
You can prevent headaches by using choline supplements alongside this drug. To prevent insomnia, use Sunifiram earlier in the day.
How Does Sunifiram Work?
Sunifiram has a somewhat similar chemical structure to Piracetam. This has led some researchers to believe that both may work similarly in the body or the brain, too. However, Sunifiram’s definite mechanism of action still remains unknown.
Here are a few proposed mechanisms of action of Sunifiram:
1. May increase acetylcholine activity
In the first few animal studies involving mice, Sunifiram reversed the effects of scopolamine, a drug that inhibits the release of the neurotransmitter acetylcholine. This finding convinced the researchers conducting the study that Sunifiram works by stimulating the release of acetylcholine. [R]
2. May activate AMPA receptors
AMPA receptors are responsible for sending messages throughout the central nervous system. An animal study hypothesizes that Sunifiram activates AMPA receptors. That’s because it was found reversing the effects of several drugs that suppressed AMPA activity. [R]
3. May activate NDMA receptors
NDMA receptors play a crucial role in our learning and memory. A mice study involving Sunifiram found this nootropic activating the neurotransmitter glutamate. This links Sunifiram to the activation of NDMA receptors, as that’s what glutamate receptors do. [R]
Benefits of Sunifiram
What we can say for sure about Sunifiram is that it’s an ampakine. It crosses the blood-brain barrier to trigger glutamate receptors in the brain and stimulate the release of acetylcholine (aka the learning neurotransmitter). The result of these processes is improved memory and learning. [R]
Being an ampakine helps Sunifiram function as a mild stimulant. This means it boosts your mental energy and alertness levels. That too without exposing you to the negative side effects (i.e. restlessness, anxiety, panic, etc.) that stimulants like caffeine and amphetamines make you experience.
Here are the benefits you can expect to get from Sunifiram:
- Faster Learning
- Improved Focus
- Mood Enhancement
- Higher Sex Drive
Let’s expound on all these Sunifiram effects:
1. Faster Learning
Research has shown that Sunifiram stimulates the release and production of acetylcholine in the brain. High acetylcholine levels have been associated with improved brain function, enhanced brain memory, better mental health, and various other benefits. [R]
The utility of acetylcholine isn’t limited to improved memory only. This neurotransmitter performs various other important functions in the body too. It prevents the imbalances in acetylcholine levels, which, if not addressed, could lead to Alzheimer’s disease, Parkinson’s disease and liver disease. [R]
2. Improved Focus
Multiple users report that taking Sunifiram has boosted their focus. This, they claim, has helped them get rid of brain fog and made them more productive at work. The reason why you may want to believe in such anecdotal evidence is that scientific evidence backs it.
At least one study has found that acetylcholine enhances attentional focus. It achieves this objective by modulating neural activity in the sensor regions of your brain. These regions are responsible for regulating your attention span. [R]
3. Enhanced Mood
Some users claim that Sunifiram has helped them overcome mood swings. Others credit this supplement for helping them develop a positive mindset. There are also tons of reports of users experiencing more energy after taking Sunifiram for 1 to 2 months.
That Sunifiram increases your energy levels and boosts your mood shouldn’t come as a surprise. Various studies have attested that increased focus leads to higher happiness levels. Sunifiram, by delivering the former, indirectly provides the latter, too. [R]
4. Higher Sex Drive
Most people assume that to increase your sex drive, you must increase testosterone first. While it’s true that higher testosterone levels contribute to increased libido, they aren’t the only factor. One could increase their sex drive through other means, too.
One of these ways is reducing stress. Research has shown that high-stress levels lead to low libido by increasing your blood pressure, heart rate and breathing rate. Sunifiram, by elevating your mood, brings all these vital signs under control, thereby helping you be at your best in bed. [R]
Keep in mind that Sunifiram has been proven to be four times more potent than Piracetam. It’s more potent than other nootropics on the market too. That’s probably why many users claim that taking it in very small doses will deliver the desired effects.
Having said that, it is not easy to find a legitimate recommended dosage. The fact that FDA hasn’t approved it (yet) prevents doctors from prescribing it, and we’ve come across very few clinical trials that could give us a clue on recommended Sunifiram dosage.
Based on user experience, up to 10 mg, three times a day, will deliver the desired effects. You can take Sunifiram sublingually or orally. Sublingual usage might be better as it will help the nootropic get into your bloodstream much quicker.
To ensure your safety and well-being, try to start with the smallest (5 mg) dose. Stick with it for a few days and see how your body responds to this nootropic. If you feel that you can tolerate the effects, you might increase your dosage to up to 10 mg.
Sunifiram Side Effects
We’re yet to come across any Sunifiram user reporting serious side effects. Another good news is that this nootropic has no known toxicity threshold. And it’s a proven fact that this toxicity profile is similar to Piracetam, which is known for its low toxicity profile.
Having said that, there are a few reports of Sunifiram users experiencing these mild side effects:
- Stuffy Nose
- Increased Perspiration
If you haven’t used nootropics before, stick to the same range mentioned above. Also, we suggest you consult your doctor before taking this smart drug, especially if you’ve prior health issues or are already on other medications/supplements.
Some users suggest stacking Sunifiram with other nootropics to boost its effects. Personally, we don’t think that you need to stack Sunifiram with anything (because it’s so powerful on its own), but you can if you want.
Having said that, it’s suggested to stack Sunifiram with a choline supplement. Alpha GPC is an exciting and trusted choline supplement, and one of the best nootropics on the market right now.
Doing so will minimize the risk of headaches, one of Sunifiram’s commonly reported side effects. It may also prevent other adverse effects of taking Sunifiram.
You can also stack Sunifiram with caffeine and L-Theanine, to get a little bit of extra focus and energy, while simultaneously making you feel calm and relaxed. It’s quite the nootropics stack if you ask us.
Frequently Asked Questions
Is Sunifiram legal?
Sunifiram isn’t approved for human consumption in the US. It still carries the status of an investigational drug. Still, you can legally buy, possess and use Sunifiram.
Is Sunifiram a stimulant?
Sunifiram is a mild stimulant. It boosts your mental clarity and alertness levels without exposing you to the negative side effects (i.e. restlessness, anxiety, panic, etc.) that strong stimulants like caffeine and amphetamines force you to experience.
How does Sunifiram compare Vs Unifiram?
Sunifiram and Unifiram are both potent cognition-enhancers. Research has shown that the duo is four times more potent than Piracetam. There’s one major difference between the two – Unifiram has been found to increase information transfer between brain cells in animal studies. [R]
Sunifiram is one of the most potent nootropics out there. Various studies have found this supplement to be four times more potent than Piracetam.
However, despite being incredibly potent, this substance’s toxicity profile is similar to that of Piracetam. This means that it’s not only powerful but also safe.
You can thus count on Sunifiram to deliver the benefits mentioned above – improved memory, enhanced learning, heightened sexual drive – without endangering your health.
Keep in mind that the FDA doesn’t regulate this supplement. You’d thus do well to buy Sunifiram from a trusted vendor like Science Bio that ensures third-party testing of all their products.