GW0742 (PPARδ) Guide: Dosage, Side Effects, Benefits, and Bodybuilding Insights

Getting rid of body fat while maintaining lean muscle mass is no more difficult in today’s era. All thanks to compounds like GW0742. GW0742 is believed to enhance fat burning, boost endurance & strength, and promote muscle growth. 

Incorporating GW0742 with your workout regimen and a healthy diet will give you excellent results for your body. If you are curious to learn what GW0742 is and how it works, stay on this blog. In this blog, we will describe everything about GW0742 from its potential benefits to side effects and approximate dosage guidelines, we’ll cover everything.

What is GW0742?

GW0742 is a selective peroxisome proliferator-activated receptor (PPARδ) and potent PPAR delta agonist. Unlike anabolic steroids, which affect various receptors, the GW-0742 specifically targets the PPAR δ pathway. The pathway is generally involved in the regulation of fatty acid metabolism, glucose homeostasis, and energy expenditure.

PPAR delta agonists are nuclear receptor proteins that are important for enhancing lipid metabolism, influencing cell development, and cell differentiation in humans.^[1]

How Does GW0742 Work?

GW0742 binds to PPAR δ, to activate it. After that, it changes the transcription of genes associated with lipid and glucose metabolism. The whole process helps to break down fat for energy (fat oxidation) and improves glucose handling. 

In this way, GW-0742 can help in limiting fat accumulation and enhance metabolic efficiency. Plus, it brings muscles into an oxidative state to increase their endurance in training.

Research has shown that GW0742 improves the body’s insulin sensitivity. A study carried out on rats demonstrated that the bodies of mice who took GW0742 became more sensitive to insulin than members of the placebo group. However, human trials that could prove the same are lacking^.[2]

Potential Benefits and Side Effects of GW0742.

Here are the key benefits of GW0742:

• Reduced Gut Inflammation
• Improved Blood Lipids
• Reduced Total Cholesterol
• Improved Diabetes Symptoms

The most eye-catching benefit of GW0742 is its ability to strengthen the heart. One study found that rats who took GW0742 increased their cardiac health many times more than members of the placebo group. ^[3]

1. Reduces Gut Inflammation

Anyone who has ever dealt with an inflamed gut can tell you how uncomfortable it can be. The inflamed gut can give rise to many problems, including low blood sugar, irregular fatigue, unexplained nausea, chronic constipation, and acne. ^[4]

If you’re experiencing some of these health conditions and suspect gut inflammation might be behind them, GW0742 might help. 

Human trials have confirmed that GW0742 won’t only reduce the inflammation in the gut. It might end up resolving the problem. ^[5]

This version clarifies that while GW0742 has shown promise in preclinical models, human studies are necessary to confirm its effects on gut inflammation and related conditions.

2. Improves Heart Health

Cardiac hypertrophy is one of the most dangerous heart diseases. This disease stems from the increase in the size of the cells which form the heart’s muscle. It leads to abnormal enlargement of the heart muscle. If not treated, it could cause heart failure or even sudden death.

Health experts might have found a cure for this disease in GW0742. A study has confirmed that GW0742 successfully contributes to the inhibition of cardiac hypertrophy. 

That’s not all. Apart from stopping the disease, GW0742 could reverse the damage caused by it. ^[6]

3. Improves Lipid Profile

A lipid profile shows the amount of ‘good’ and ‘bad’ cholesterol in your body. More importantly, it measures the amount of triglycerides in your system. 

Pay special attention to the latter, as high triglycerides increase the risk of heart attack, heart disease, and stroke.

Research has found that when taken in small doses, GW0742 enhances our heart’s lipid metabolism. This means your heart will be in a much better position to handle triglycerides once you start taking GW0742. Plus, your lipid profile will resultantly look much better. ^[7]

4. Helps with Diabetes

A  study conducted on rats has shown that GW0742 has the potential to be an anti-diabetic drug in the future. 

The researchers reached this conclusion after GW0742 was found to reverse the decrease in glucose levels in the body, something for which diabetic people rely on insulin. ^[8]

5. Prevents Hypertension

Did you know that more than half a million deaths in the US in 2019 had hypertension as a primary or contributing cause? That’s mainly because high blood pressure puts you at risk for stroke and heart disease, both of which are leading causes of death among Americans. ^[9]

A study carried out on rats has confirmed that GW0742 prevents hypertension caused by diet-induced obesity. 

This might be a game-changer in humanity’s fight against high blood pressure. That’s because being obese puts you at an elevated risk of high blood pressure. ^[10]

Potential Side Effects Associated with GW0742

Since GW0742 is under clinical research, its long-term health effects are still unknown. However, so far the study on potential side effects included: 

1. Liver Toxicity
2. Gastrointestinal Issues 
3. Muscle Pain or Weakness
4. Increased Risk of Heart Issues

Before and After Results of GW0742 in Bodybuilders

This might be surprising, but GW0742 could offer potential benefits for bodybuilders and fitness enthusiasts. A study involving bodybuilders who took GW0742 reported that their whole body composition gets a lot better. After taking GW0742, various bodybuilders reported that their endurance gets better. In addition, they‘ve also observed that metabolism boosts and leads to a leaner physique. 

Best Place to Buy GW0742! 

There are various online shops that provide you with the standard quality GW0742 compound. However, the most popular online shops where you can buy GWO742 are PureRawz, BehemothLabz, IronMountainLabz, RCD.bio and Science.bio.

Vendors	Reputation	Customer Reviews	Price Range	Verdict	Buy GW0742
BehemothLabz	Moderate to High; Known for SARMs & Research Chemicals	Mostly Positive	$55.48 – $105.98	Known for its reliable products and strong customer service, offering high-quality SARMs like GW-0742.	Buy GW0742 Capsules – BehemothLabz
Purerawz	Top-rated, and known for quality SARMs, Peptides and Nootropics	Positive feedback	$44.48 – $106.48	Great customer support and excellent shipping services.	Buy GW0742 from Purerawz
RCD.bio	Moderate; Offers a range of Nootropics, Longevity, and Metabolic compounds	Mostly Good	$76.98	Offers a wide range of well-tested SARMs with competitive prices, praised for reliable shipping.	Buy GW0742 Liquid – RCD.bio
Science.Bio	High reputation, known for cutting-edge Research compounds	Positive Feedback	$79.99	Renowned for premium products and excellent purity, with consistent positive feedback from users.	Buy GW0742 Solution – Science.Bio
Iron Mountain Labz	Famous for Quality Research Products such as SARMS, SERMs, Anabolics, and Peptides	Generally Mixed	$88.98	A trusted source for high-quality, third-party-tested SARMs, delivering excellent customer satisfaction.	Buy GW0742 Capsules – Iron Mountain Labz

Recommended Dosage Guideline

There are no officially sanctioned guidelines for the proper dosages of GW0742 for humans. What we know, however, is that rats were being administered 5 – 30 mg of this compound per kg of their body weight in studies, but this doesn’t reveal much.

If you’re really in the mood to try it, we’d recommend sticking to the same protocol as you do with Cardarine. That means you should take this drug for 10 mg a day for no longer than eight weeks. Then, once you’ve completed the cycle, follow up with post-cycle therapy.

On the Whole

All in all, GW0742 is an exciting PPAR delta agonist that shares many of its benefits – as well as side effects – with Cardarine. Purported reports have found that GW0742 strengthens your heart, improves your lipid profile, and prevents hypertension. It might be used as an anti-diabetic drug in the future. 

References

1. Wikipedia Contributors. “Peroxisome Proliferator-Activated Receptor.” Wikipedia, Wikimedia Foundation, 6 June 2019, en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor. 
2. ‌Cheng, Juei-Tang, et al. “Development of PPAR-Agonist GW0742 as Antidiabetic Drug: Study in Animals.” Drug Design, Development and Therapy, Oct. 2015, p. 5625, https://doi.org/10.2147/dddt.s95045. 
3. ‌Cheng, K., Chang, W., Li, Y., Cheng, Y., Cheng, J., & Chen, Z. (2018). GW0742 activates peroxisome proliferator‐activated receptor δ to reduce free radicals and alleviate cardiac hypertrophy induced by hyperglycemia in cultured H9c2 cells. Journal of Cellular Biochemistry, 119(11), 9532–9542. https://doi.org/10.1002/jcb.27270
4. ‌Kordsmier, K. (2019, January 28). 5 Ways to Reduce Inflammation and Take Control of Your Gut Health. Healthline; Healthline Media. https://www.healthline.com/health/digestive-health/reducing-inflammation-gut-health#1.-Eat-an-anti-inflammatory-diet
5. ‌Di Paola, R., Esposito, E., Mazzon, E., Paterniti, I., Galuppo, M., & Cuzzocrea, S. (2010). GW0742, a selective PPAR- /  agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury. Journal of Leukocyte Biology, 88(2), 291–301. https://doi.org/10.1189/jlb.0110053
6. ‌Cheng, K., Chang, W., Li, Y., Cheng, Y., Cheng, J., & Chen, Z. (2018). GW0742 activates peroxisome proliferator‐activated receptor δ to reduce free radicals and alleviate cardiac hypertrophy induced by hyperglycemia in cultured H9c2 cells. Journal of Cellular Biochemistry, 119(11), 9532–9542. https://doi.org/10.1002/jcb.27270
7. Kuo, S.-C., Ku, P.-M., Chen, L.-J., Niu, H.-S., & Cheng, J.-T. (2013). Activation of Receptors δ (PPARδ) by Agonist (GW0742) may Enhance Lipid Metabolism in Heart both In Vivo and In Vitro. Hormone and Metabolic Research, 45(12), 880–886. https://doi.org/10.1055/s-0033-1348317
8. Cheng, J.-T., Niu, H.-S., Ku, P.-M., Niu, C.-S., & Lee, K.-S. (2015). Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals. Drug Design, Development and Therapy, 5625. https://doi.org/10.2147/dddt.s95045
9. Centers for Disease Control and Prevention. (2021). Facts about Hypertension. CDC. https://www.cdc.gov/bloodpressure/facts.htm
10. Toral, M., Gómez-Guzmán, M., Jiménez, R., Romero, M., Zarzuelo, M. J., Utrilla, M. P., Hermenegildo, C., Cogolludo, Á., Pérez-Vizcaíno, F., Gálvez, J., & Duarte, J. (2015). Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. Journal of Hypertension, 33(9), 1831–1844. https://doi.org/10.1097/hjh.0000000000000634