GLP-1 Guide – Benefits, Side Effects, Dosage, and More
Many people underestimate how widespread obesity and type 2 diabetes are in the US. While the former condition affects 41% of adults aged 20 and above, more than 37 million Americans have type 2 diabetes, a number which translates to 1 in every 10 Americans.
As demoralizing as these numbers are, one thing might uplift your mood. GLP-1 receptor agonists, drugs that mimic the action of this hormone, can treat both. Need proof? The FDA has approved many of these medicines as treatments for type-2 diabetes and obesity.
Liraglutide is one such FDA-approved drug that can offer the best of both worlds. Studies show that people who use Liraglutide and make lifestyle changes can lose up to 16 pounds. The decrease in blood sugar levels for those with type 2 diabetes can be in three figures
This article will tell you all you need to know about this GLP-1 receptor agonist. We’ll kick things off by discussing what GLP-1 and Liraglutide are and how they work. Next comes the meaty part – the benefits everyone could acquire by supplementing Liraglutide regularly.
What is GLP-1?
Glucagon-like peptide 1 is a hormone produced in the intestine. It regulates/lowers blood sugar levels by enhancing insulin secretion (to allow cells to take up blood glucose). GLP-1 also inhibits glucagon secretion (to prevent glucose uptake into the bloodstream).
GLP-1 performs another equally crucial function. It slows stomach emptying by making sure that less glucose from food is released into the bloodstream. This has a two-fold impact: it increases your satiety (helps you feel full) and contributes to weight loss.
As an agonist of GLP-1, Liraglutide performs both these functions. Research has shown that combining this peptide with lifestyle changes can help obese people lose up to 16 pounds within a few months, with an equally significant reduction in blood sugar levels.
However, the benefits of Liraglutide don’t end there. This GLP-1 analog has also shown promise as a potential treatment for osteoarthritis by strengthening bones. In addition to that, Liraglutide may improve your heart health, lipid profile, and fight inflammation.
How Does GLP-1 Work?
GLP-1 and Liraglutide have two possible mechanisms of action:
- Regulates glucagon and insulin secretion. Research has shown that Liraglutide binds to and activates the GLP-1 receptors in the body, increasing insulin secretion while simultaneously lowering glucagon synthesis. [R]
- Slows the emptying of the stomach. Liraglutide injections have demonstrated the ability to delay the release of food from inside the stomach, thereby decreasing appetite and causing weight loss. [R]
By lowering glucagon synthesis and having an effect on the release of food from inside the stomach, it’s been shown that GLP-1 can have a very positive effect on weight loss.
Multiple studies have shown that the benefits of Liraglutide extend beyond lowering blood sugar levels and inducing significant weight loss. This GLP-1 analog can also improve cardiac function and reduce the hospitalization rate of patients with type 2 diabetes and high cardiovascular risk.
Liraglutide treatment can also lower blood pressure levels, improve the body’s insulin resistance, and boost bone strength. The last benefit increases the appeal of this supplement for the elderly or anyone whom doctors adjudge to be at a high risk of developing osteoarthritis.
All the above benefits can be acquired at lower doses (revealed below). Higher doses of this glucagon-like peptide can induce various side effects, some of which can be severe. With this in mind, let’s look at the multiple benefits of Liraglutide GLP-1 receptor agonist:
1) Helps with weight loss
Clinical trials have shown that Liraglutide induces significant weight loss, similar to compounds such as Cardarine, just by using a different mechanism of action, though.
For instance, in a double-blind study involving 3,731 obesity patients, 1x daily injection of Liraglutide saw 63.2% of patients lose at least 5% of their body weight. What’s more, more than 33% of the Liraglutide group had 10% less weight at the end of the study than at the beginning. [R]
In two more trials, obesity patients with body mass index (BMI) between 30 and 40 experienced significant weight loss. Significantly, patients in a low-dose group lost more body weight than those receiving a higher dose of this drug. [R] [R]
2) Lower blood sugar levels
Did you know that Liraglutide is an FDA-approved treatment for type 2 diabetes?
The approval came on the heels of various trials that showed this drug helping patients with type 2 diabetes achieve good glycemic control. It did that by stimulating increased insulin secretion, which is key to keeping your blood sugar levels in the normal range. [R] [R]
Similarly, another study found that Liraglutide can improve plasma glucose levels in patients with type 2 diabetes. Thanks to results like this, Liraglutide was first approved by the European Medicines Agency (in 2009) and then by FDA (in 2010) as a treatment for type 2 diabetes. [R]
This means that GLP-1 may actually be good to pair with Ibutamoren (MK-677) to counteract the high blood sugar effects that MK-677 can sometimes cause.
3) Improves bone strength
Liraglutide could improve bone strength by preserving bone mineral density.
Bone mineral density tells you how much calcium and other types of minerals are in a specific area of your bone. If your BMD falls below a certain level, osteoporosis occurs. However, before that happens, other serious medical conditions (such as bone fractures) might alter your quality of life.
The good news is that Liraglutide can help retain your BMD. This was proven in a study in which 1.8 mg daily treatment of Liraglutide preserved bone mineral density in patients with type 2 diabetes. This shows that this drug could keep conditions like osteoporosis at bay. [R]
4) Might reduce alcohol dependence
Two back-to-back studies showed how Liraglutide could reduce alcohol dependence.
The first of the studies laid out the mechanism with which this drug could help overcome alcohol addiction. It showed that GLP-1 receptor analogs had a preventive effect on alcohol cravings, meaning substances which bind to GLP-1 receptors can decrease alcoholism. [R]
A second study showed Liraglutide doing just that. Conducted on animals, this study revealed that Liraglutide-treated rats consumed 30 to 40% less alcohol than those administered saline, even though both groups had the same alcohol intake at the study’s beginning. [R]
5) Improves lipid and lipoprotein profiles
A poor lipid profile opens the door to a plethora of cardiovascular issues, such as coronary heart disease and atherosclerosis. A poor lipoprotein profile is even worse, as it raises the risk of your heart vessels getting clogged, causing a heart attack.
In a randomized, placebo-controlled trial, short-term treatment with Liraglutide improved the lipid and lipoprotein profiles of obese patients. This is significant as overweight people are at an increased risk of cardiovascular problems than those with normal weight. [R]
6) May slow spread of dementia
Liraglutide might be effective in slowing the spread of dementia in the brain
A small-scale trial in patients with Alzheimer’s disease reported that a 26-week treatment with this drug prevented a decline in brain metabolism. Put simply, Liraglutide induced such changes in the brain that could allow brain cells to function longer. [R]
Combined with the best nootropics on the market right now, GLP-1 could be a great way to increase your overall mental acuity, and improve overall brain health as well.
Multiple users have taken to Reddit to share their experiences of using Liraglutide.
One of them has claimed that they ‘lost 10 kg’ after using this drug for 6 months. Another stated that they ‘lost 48 kg’ after taking Liraglutide for 2 years. [R]
Another user pointed to the ‘stomach full’ effect of this drug, claiming that after using this drug for only 2 days, they are not hungry and have to remind themselves to eat.
These anecdotal experiences all but confirm what the above studies found: Liraglutide GLP-1 can induce weight loss as well as decrease appetite by reducing the rate of gastric emptying.
Obese people who want to lose weight are suggested to follow a six-week dosage plan. Combining this plan with a reduced calorie diet and increased physical activity will give better results.
Liraglutide dosage plan for weight loss:
- Week 1: 0.6 mg/day
- Week 2: 1.2 mg/day
- Week 3: 1.8 mg/day
- Week 4: 2.4 mg/day
- Week 5: 3.0 mg/day
High doses of Liraglutide must be avoided at all costs. It has been shown that an overdose could cause hyperglycemia, or too high blood sugar levels. Severe nausea, occasional abdominal pain, and vomiting has also been reported in the cases of Liraglutide overdose reported in the literature. [R]
How to Take Liraglutide?
Liraglutide is injected under the skin of stomach, thighs, or upper arm.
Make sure not to take Liraglutide with other drugs that can cause hypoglycemia. Since this drug has been shown to significantly increase resting heart rate, patients with cardiovascular disease should exercise caution.
Where to Buy GLP-1?
Pure Rawz is the best place to buy Liraglutide GLP-1 online.
Pure Rawz provides reference materials with every product we sell. All of their products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
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GLP-1 Side Effects
In several clinical trials, Liraglutide has been found to be generally safe and well-tolerated. [R]
However, in rare cases, side effects may occur. Consult with your doctor if any of these symptoms become severe or do not go away:
- Difficulty urinating
- Injection site rash
Overall, most people don’t experience side effects, especially when taking GLP-1 in the recommended dosages.
In summary, GLP-1 is a great compound that can easily be used to enhance your weight loss, help you cut off excess pounds of fat, and even has benefits beyond this, like improving cholesterol.
If you do decide to buy GLP-1, we recommend you get the stuff that PureRawz has. They’re our favorite vendor so far, and every batch of their GLP-1 for sale is 3rd party tested for the utmost purity.
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As always, be sure to leave any comments you have or questions down below, and we’ll do our best to get back to you as fast as we can!