Tesamorelin Guide: Dosage, Benefits, Effects & More (2022)

Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH). It increases the endogenous production of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Tesamorelin is clinically used to treat HIV-associated fat build-up in the abdomen area. 

At the time of writing, various studies are exploring the potential of Tesamorelin to improve peripheral nerve health. Tesamorelin is also being investigated for its ability to slow the progression of dementia/mild cognitive impairment and the reduction in body fat mass.

This comprehensive guide will tell you everything you need to know about Tesamorelin. We’ll kick things off by discussing what Tesamorelin is and what it does. Next, we’ll focus on this synthetic peptide’s clinical use and potential benefits before looking at the optimal dosage.

What is Tesamorelin?

Tesamorelin Molecular Structure

Tesamorelin is a peptide with a 44 amino acid chain. Peptides, like PT 141 for example, are small chains of amino acids that can help you build muscle, boost body weight, and lose fat. They also help lower blood pressure, prevent the formation of blood clots, and improve immune function. [R]

Tesamorelin acts as a peptide analog of growth hormone-releasing hormone (GHRH), meaning it enhances the synthesis and production of HGH in the body. While it is based on the same sequence as GHRH, there are several differences between GHRH and Tesamorelin. [R]

The first of which is that Tesamorelin is much more potent than GHRH, meaning its effects will be more clearly felt. Secondly, unlike GHRH, it’s more resistant to getting destroyed by enzymes. For this reason, you can expect Tesamorelin to provide long-lasting results. [R]

What Does Tesamorelin Do?

Tesamorelin has been shown to:

1) Stimulate the synthesis and release of endogenous GH

Tesamorelin has been proven to steadily increase the body’s production and release of growth hormone. Reportedly, it does that by stimulating the production of growth hormone-releasing factor, which, in turn, stimulates GH production. [R][R]

This makes it similar in effect to MK-677 (Ibutamoren). We’ve already covered that research chemical in-depth so you can click there and read more if you want to learn more.

2) Stimulate the production of IGF-1

Tesamorelin also stimulates the production of insulin-like growth factor-1 (IGF-1), a hormone that mediates the effects of GH. IGF-1 plays an important role in fetal development, growth during childhood and adolescence, and maintenance of an internal steady state. [R][R]

3) Reduce visceral adipose tissue

Tesamorelin reduces visceral adipose tissue in a two-step process. First, it induces lipolysis by acting on adipocytes (fat cells). This is followed by a reduction in triglyceride levels in the body. Both these steps result in a visible reduction of body fat, especially in the stomach area. [R]

What is Tesamorelin Used for?

Tesamorelin is clinically used for the treatment of HIV-associated lipodystrophy. Lipodystrophy is characterized by the build-up of excess fat in several body areas of HIV patients. Tesamorelin is specifically used to reduce excess abdominal fat in HIV-infected patients. [R]

Bodybuilders also use Tesamorelin for sale in order to increase the quality of their gains, burn fat faster, build muscle faster, get more focus and energy in the gym, and increase growth hormone levels.

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It’s a popular and fast-growing supplement that people are now realizing can help you pack on many pounds of lean muscle very rapidly. In fact, I wouldn’t be surprised if this compound is a household name in a year or two amongst bodybuilders.

Tesamorelin Benefits

Tesamorelin has been shown to offer various benefits. However, it’s recommended to consult with your healthcare provider before you start using this drug. Only a licensed medical professional can tell you more about possible drug interactions and allergic reactions.

1) Reduce body fat

While a healthy amount of body fat is crucial to normal daily functioning, excess body fat has been linked to type 2 diabetes, osteoarthritis, and cancer. [R]

According to a randomized placebo-controlled trial, a 12-month Tesamorelin treatment reduced visceral adipose tissue by 19 9% in HIV-infected patients with central fat accumulation. The patients’ waist circumference and waist-hip ratio also improved. [R]

2) Increase protein synthesis

Protein synthesis is the process by which cells make proteins. It plays a crucial role in the manufacturing of enzymes and hormones, as well as muscle build-up.

Clinical studies have shown that Tesamorelin increases protein synthesis in the body, implicating this GHRH analog in the build-up of muscle and body functioning. [R]

3) Improves cognitive function

According to a 2012 study published in Archives of Neurology, Tesamorelin positively affected the cognition of healthy older adults or patients with mild cognitive impairment. [R]

In addition to improving cognitive function in healthy adults, Tesamorelin also attenuated expected functional decline of patients with mild cognitive impairment. A significant improvement in executive function and, to a lesser degree, short-term verbal memory was also reported. [R]

4) Reduces triglyceride levels

Triglycerides are a type of fatty acid (lipid) found in your blood. High triglyceride levels may increase your risk of heart attack, stroke, and heart disease.

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At least three clinical studies have reported that Tesamorelin reduces triglyceride levels in human immunodeficiency virus (HIV) patients. All these trials reported that this effect wasn’t accompanied by an increase in patients’ glucose levels.  [R][R][R]

5) Enhances verbal memory

In a randomized, double-blind trial, Tesamorelin treatment for 20 weeks enhanced short-term verbal memory in healthy elderly adults and patients with mild cognitive impairment. [R]

Authors conducting the study state that GHRH boosted memory by stimulating increases in circulating insulin in the bloodstream. [R]

Tesamorelin Side Effects

side effects

Clinical studies have shown that Tesamorelin is generally well-tolerated.

However, in extremely rare cases, you may have an allergic reaction. Contact your doctor immediately if these effects occur to you: difficulty breathing, swelling of your throat, lips, tongue, or throat, and joint pain. If you suspect an overdose, call your poison control center right away.

Do not use Tesamorelin if you have cancer, are pregnant, or have a history of pituitary gland tumor. Do not breast feed while on this drug or inject it into scar tissue. It is also unknown how Tesamorelin may react with over-the-counter medications.

Tesamorelin Dosage

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The usual adult dose of Tesamorelin is 2 mg subcutaneously (under the skin) once a day. It’s recommended to consult a licensed medical health professional to know the appropriate Tesamorelin dosage for yourself.

Personally however, we prefer the Tesamorelin nasal spray available from PureRawz, because it’s way easier to pump a spray in your nose each day than having to draw liquid and inject it.

Keep in mind there’s no official dosage for bodybuilding as this is an off label use, but most bodybuilders will say that just doing 1 spray per day for 60-90 days is enough to improve your physique significantly.

Conclusion

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Tesamorelin is a GHRH analogue clinically used to treat lipodystrophy in HIV-infected patients. Clinical research has shown that it increases cognitive function, enhanced protein synthesis, and lowers triglyceride levels. Tesamorelin has also been reported to enhance short-term verbal memory.

All in all, Tesamorelin is a wonder drug that not only functions as an anabolic compound, but also as a nootropic compound—improving not only your physique, but your brain as well.

If you want to get the best, purest Tesamorelin, we recommend you check out PureRawz. Every batch of their products are 3rd party verified and rigorously tested for the highest quality possible.

Use the code “MD15” for 15% off. If you have any questions let us know in the section below and we’ll try our hardest to answer them in a timely manner.

Frequently Asked Questions
❓ Is Tesamorelin FDA-approved?

Yes. The FDA approved Tesamorelin in 2010 to treat HIV-infected patients with lipodystrophy.

❓ What to do if you miss a dose of Tesamorelin?

In the event of a missed dose, take the next dose as soon as possible.

❓ How long does it take Tesamorelin to work?

The length of time it might take Tesamorelin to work depends on your condition, the purpose for which you're using this drug, and the dosage amount.

Nanotech Project Team
 

Nanotech Project is dedicated to helping readers discover the safest, and most clinically-based way to apply SARMs, nootropics, anabolics, metabolics, and other research chemicals. We specialize in dissecting research on supplements, and other compounds that bodybuilders often use.

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