Pramiracetam is one of the most popular nootropics right now.
Users of this nootropic vouch for its potency. They claim that a 2-month course rivals the best nootropics, in terms of brain power boosted and cognition enhanced.
In this Pramiracetam review, we’ll explore the science behind this nootropic to help you decide whether you should start using this supplement or not. Continue reading!
What is Pramiracetam?
Pramiracetam is a synthetic racetam derivative, just like Oxiracetam. It was initially developed in the late 1970s by the Parke-Davis pharmaceutical company and was distributed under the Primastar brand name.
Pramiracetam was originally synthesized to help patients suffering from brain injury, neurodegenerative disorders, and various central nervous system disorders. Later on, in April 1993, it was marketed as a treatment for age-associated memory loss.
What makes Pramiracetam unique is that it’s 30 times more powerful than piracetam, the nootropic from which it is derived. Piracetam has been proven to boost brain function and enhance cognition. It could also reduce negative cognitive symptoms.
How does Pramiracetam Work in the Brain?
Pramiracetam increases the synthesis and function of acetylcholine in the brain. Acetylcholine is one of the nervous system’s major neurotransmitters. It is responsible for expanding blood vessels, helping muscles to relax, slowing the heart rate, and boosting memory.
Aside from that, Pramiracetam increases nitric oxide activity in the brain. Nitric oxide is crucial for our brain health. It allows cerebral blood flow, thereby improving the efficiency of brain cells (neurons) involved in memory function, learning, and visual function.
Remember that Pramiracetam primarily acts via acetylcholine pathways and shows minimal interaction with other neurotransmitters. That is something that sets it apart from the best nootropics right now. For this reason, it cannot improve mood and alleviate anxiety issues.
Potential Benefits of Pramiracetam
In various studies, Pramiracetam has been shown to have the following benefits.
1) Improves Memory
Almost 10% of US adults over 45 report memory issues. That is a massively worrying statistic. The decline in mental abilities is one of the earliest signs of impending dementia or Alzheimer’s disease, according to the US Centers for Disease Control and Prevention.
Research has shown that Pramiracetam could improve the formation of new memories and the retention of existing ones.
2) Reverses Cognitive Decline
Cognitive decline is a normal part of aging. Health experts tell us that a few mild changes in cognition are nothing to worry about as you age. However, while a slight reduction in one’s memory, mental acuity, or judgment is normal, dementia isn’t.
A meta-analysis has found that Pramiracetam can effectively reverse various symptoms of cognitive impairment. The analysis found Pramiracetam to be ‘globally’ efficacious in reversing cognitive impairment symptoms in older adults.
3) Increases Mental Alertness
Mental alertness is a crucial recipe for success. When your brain is foggy, it will make you hesitate a hundred times before reaching a decision.
Preliminary evidence shows that Pramiracetam increases nitric oxide synthesis in the hippocampus. This is relevant because the hippocampus plays a crucial role in memory-guided decision-making. By increasing nitric oxide in this region, Pramiracetam could make you more alert to the world around you.
4) Offers Neuroprotection
Neuroprotection refers to the preservation of the brain cells’ structure and/or function. It’s a set of mechanisms and strategies that protect your nervous system from damage and injury, especially in people who are already dealing with some sort of brain damage or injury.
Pramiracetam might have what it takes to be classified as a ‘neuroprotector’. In one human case, it successfully reduced the symptoms associated with memory loss.
5) Improves Learning Ability
Researchers have identified why we lose learning ability as we age. Our brain’s hippocampus region has GABA receptors, which are at their lowest levels during adolescence (when we have the highest learning ability). As we age, the GABA levels go up, hurting our ability to learn new things.
Pramiracetam improves learning ability by targeting the hippocampus. It does that by boosting nitric oxide levels in that region of the brain. NO (Nitric Oxide) is associated with learning ability and memory in humans. By increasing its levels, Pramiracetam boosts our learning ability.
6) Enhances Cognition
According to a double-blind, placebo-controlled study, Pramiracetam enhances cognition. The study involved multiple young males. All of them were dealing with cognition problems due to brain trauma.
They were finding it hard to memorize new information and recall old memories.
Researchers divided the participants into two groups. One group took 400 mg of Pramiracetam daily for 18 months. The other got a placebo. After the study’s conclusion, it was found that the Pramiracetam group experienced a significant boost in cognition, recall, and memory.
7) Improves Dementia Symptoms
Dementia is an umbrella term for various neurological disorders that impair the patient’s ability to remember, think, or make everyday decisions. Alzheimer’s disease is one of the most famous types of dementia. Around the world, more than 50 million people have dementia as we speak.
Open-label trials have shown that Pramiracetam eases dementia symptoms. In the trials, it brought ‘measurable’ improvements to the patient’s memory and cognition. That is probably why Pramiracetam is one of the various prescription medications for Alzheimer’s disease in Europe.
Potential Side Effects of Pramiracetam
Here are the side effects of Pramiracetam:
- Gastrointestinal discomfort
- Insomnia
- Mood changes
- Dizziness, fatigue, and rare allergic reactions
- Headache
- Nausea
These side effects can be avoided by sticking to a low dosage in the US.
Where Can I Buy Pramiracetam?
If you are looking for a high-quality pramiracetam product, below are some recommended online vendors:
| Vendor | Rating | Buying Link | Verdict |
| PureRawz | 4.7/5 | Buy Pramiracetam from PureRawz | High-quality, trusted vendor |
| RCD Bio | 4.6/5 | Buy Pramiracetam Powder from RCDBio.co | Pure powder form, excellent reputation |
Pramiracetam Dosage
Human studies have shown that it’s safe to take up to 1,200 mg of Pramiracetam per day.
You could split the total dosage into two or three smaller doses. Try to take the last dose well before bedtime, as this smart drug is capable of causing insomnia.
Make sure not to take more than the recommended dosage. Pramiracetam is significantly more potent by weight compared to Piracetam. There’s a risk of overdose if you exceed your daily dose. An overdose might lead to poisoning or other adverse effects, including heartburn, stomach pains.
Pramiracetam Stacks
Pramiracetam gives you multiple stacking options.
You could combine it with other racetams. Pramiracetam is a powerful potentiator and is capable of increasing the effectiveness of most nootropics.
You could also add a choline supplement to your existing Pramiracetam stack. This will help you avoid headaches, this smart drug’s most-reported side effect.
Since Pramiracetam is highly potent, we recommend that you don’t use it as a part of a stack for the first 2-3 months. Observe how your body reacts to this racetam alone, and then mix it with nootropics.
Here are the best Pramiracetam stacks:
1) Pramiracetam Oxiracetam Stack
1x per day: 300 mg Pramiracetam; 750 mg Oxiracetam; 300 mg CDP Choline
Stacking Pramiracetam with another cognitive enhancer like Oxiracetam will give you two benefits. It will increase the effectiveness of the effects that both these racetams are capable of providing. And you’d be able to enjoy the benefits over a longer period.
2) Pramiracetam Phenibut Stack
1x per day: 300 mg Pramiracetam; 1,000 mg Phenibut
Apart from giving you all the benefits of the Pramiracetam/Oxiracetam stack – enhanced cognition, better memory retention, and increased energy – stacking Phenibut with Pramiracetam will also lead to enhanced focus, added motivation, and an enhanced sense of well-being.
Summary
In conclusion, Pramiracetam is one of the most powerful racetams right now for cognition and memory improvement, learning power enhancement and brain protection as a whole. Just one course of 2-3 months can boost your mental faculties.
Derived from piracetam, it is also capable of reversing cognitive decline and easing symptoms of dementia. Research has further shown that it boosts high affinity choline uptake to boost brain activity and cognitive function.
If you’re looking for 100% pure Pramiracetam, we recommend you get it through Pure Rawz. They’re one of the most trusted vendors when it comes to nootropics, bodybuilding, and health and nutritional supplements.
Lastly, if you have queries about Pramiracetam, nootropics, or supplements in general, please write to us using the comments box given below.
