Noopept is a fascinating new class of compounds that has grown in popularity over the past several years mainly due to its cognitive enhancement abilities.
In this blog, we’ll explore the science behind Noopept and uncover the best dosage, how to use it, and its clinically proven health benefits.
What is Noopept?
Noopept also known as N-phenylacetyl-L-prolylglycine ethyl ester is a synthetic nootropic compound that was developed in the mid-1990s, to be a more bioavailable version of a drug called Piracetam. [1]
Noopept might have the potential to improve cognitive functions such as memory, learning, and focus. It is also believed to have neuroprotective properties [2]
Noopept is a more effective, more potent, and more bioavailable version of Piracetam, a compound used to boost memory and alertness.
How Does Noopept Work?
While the mechanism of action and pharmacological effects of Noopept are still being studied, researchers believe that it works on the acetylcholine system in the brain. [3]
Acetylcholine is a critical neurotransmitter that aids in the communication of brain cells.
Another way Noopept is believed to work is by raising the brain-derived neurotrophic factor (BDNF). BDNF is a protein that helps create neural connections and neurotransmission in the brain. [4]
In addition to acting on the acetylcholine system, it’s theorized that Noopept affects AMPA and NMDA receptors as well, which explains its effects. [5]
The compound may also improve cognition by increasing endogenous neuropeptide cycloprolylglycine. [6]
Potential Benefits of Noopept
Studies show that Noopept may even help prevent Alzheimer’s disease, by preventing cell death in the brain. [7]
Users who have used the compound suggest that Noopept might have the potential to enhance memory, improve cognition, and reduce anxiety & stress. However, there is no authentic human study that claims all these effects.
A few of the other potential benefits that users have noticed are as follows:
- Might Enhance Memory
- May Improve Cognitive Function
- May Boost Focus
- May Help with Brain Fog
Might Enhance Memory
Perhaps one of the most profound effects of Noopept is its ability to enhance memory. It works on the brain’s cholinergic system and neuroplasticity to improve memory. In addition, Noopept boosts learning processes by influencing the activity of cholinergic receptors. [8]
May Improve Cognitive Function
Noopept, in particular, is thought to improve cognitive function by influencing key neurochemical pathways. [9]
The compound supports neuroplasticity through the upregulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Both of which promote the growth, survival, and maintenance of neurons.
Noopept also has neuroprotective properties that help shield the brain from oxidative stress and inflammation, which can impair cognitive function over time. [10]
May Boost Focus
Noopept’s effect on focus comes from its ability to enhance the sensitivity and function of various receptors. These receptors are involved in cognitive processing in the hippocampus and prefrontal cortex. [11]
Besides, it helps the brain to form and strengthen new connections by promoting synaptic plasticity. It ultimately leads to a better procession of information, quick learning, and enhanced memory, all of which support better focus.
May Help with Brain Fog
When a person’s focus is lacking, they often forget things or simply remain confused and less awake, ultimately encountering brain fog.
Some users have reported that Noopept helps with less brain fog. By rejuvenating the fatty tissue of the brain and enhancing its function, Noopept helps with brain fog.
Potential Side Effects Include:
The possible side effects of Noopept are as follows:
- Insomnia
- Irritability
- Depression
Noopept Dosage Guidelines:
Noopept is a far more potent version of the Racetam family, so the dosage required to achieve these benefits is far less. According to most research, as well as anecdotal evidence, the recommended Noopept dosage can vary from 30 mg to 120 mg per day.
Here is the recommended Noopept dose based on experience:
- Beginners: 10 mg Taken 3x Per Day
- Intermediate: 20 mg Taken 3x Per Day
- Advanced: 40 mg Taken 3x Per Day
Due to the fast-acting nature of Noopept, it’s recommended that you split your dose up throughout the day, to maintain an even level in the body.
Where to Buy Noopept?
While there are many places to buy Noopept online, the vast majority of vendors don’t sell high-quality nootropics, and some even sell fake junk. Our recommended vendors for research chemicals are as follows:
| Vendors | Noopept Forms | Customer Reviews | Quality Assurance | Our Suggestion |
| Purerawz | Tablet, Liquid, powder, spray | Generally Positive | 1st and 3rd party tested, with 99% purity | The vendor is famous for their affordable and quality products. |
| RCDbio.co | Powder | Satisfactory | Quality tested and contain COA | You can purchase Noopept powder or any other product from this vendor as they provide you with affordable prices products. |
| Iron mountainlabz | Nasal Spray | Customers highly recommend this brand | Meet the stringent quality testing | The vendor is known for its authenticity and reliable products. |
| BC9.co | Liquid, Powder | Generally good | Lab tested | The vendor provides you with standard-quality products. You can trust them and purchase your products from Science.bio. |
Piracetam Comparison with Noopept
One common mistake that people make is they think Noopept is the same as piracetam. Piracetam and Noopept are two entirely different drugs. Racetam family substances such as Piracetam or Aniracetam have many different active pharmaceutical ingredients than Noopept.
There are some areas where piracetam and Noopept are very similar. They are both water-soluble. They both enhance memory. They both will improve cognitive functions, and help boost your focus.
Noopept is far more effective than piracetam at improving memory. Piracetam only helps improve the first stage of memory, whereas Noopept improves not only the first stage of memory but also retaining the memory and retrieving it later.
In short, Noopept is a far more effective nootropic than piracetam.
Disclaimer
The information provided is for informational purposes only and should not be considered medical advice. Readers should consult with a healthcare professional before using Noopept or any other supplement.
On the Whole
In conclusion, Noopept is a powerful nootropic that has a wide variety of benefits, ranging from better memory to enhanced cognition and focus. It might also improve awareness and alertness.
References
- Pfiffner, M., & Examine.com. (2024). N-Phenylacetyl-L-prolylglycine ethyl ester Health benefits, dosage, and side effects. Examine.com. https://www.examine.com/supplements/noopept/?show_conditions=true
- Ostrovskaya, R. U., Vakhitova, Y. V., Kuzmina, U. S., Salimgareeva, M. K., Zainullina, L. F., Gudasheva, T. A., Vakhitov, V. A., & Seredenin, S. B. (2014). Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. Journal of Biomedical Science, 21(1). https://doi.org/10.1186/s12929-014-0074-2
- Ostrovskaia, R. U., Gudasheva, T. A., Voronina, T. A., & Seredenin, S. B. (2002). [The original novel nootropic and neuroprotective agent noopept]. Eksperimental’naia I Klinicheskaia Farmakologiia, 65(5), 66–72. https://pubmed.ncbi.nlm.nih.gov/12596521/
- Pfiffner, M., & Examine.com. (2024). N-Phenylacetyl-L-prolylglycine ethyl ester Health benefits, dosage, and side effects. Examine.com. https://www.examine.com/supplements/noopept/?srsltid=AfmBOoowak3mRApu-abKAs94R-GH5oU9SrmR0DBsoTx8D7gVrlmWfA1Z&show_conditions=true#ref-12
- Andreeva, N. A., Stel’mashuk, E. V., Isaev, N. K., Ostrovskaya, R. U., Gudasheva, T. A., & Viktorov, I. V. (2000). Neuroprotective properties of nootropic dipeptide GVS-111 inin vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress. Bulletin of Experimental Biology and Medicine, 130(4), 969–972. https://doi.org/10.1007/bf02682041
- Gudasheva, T. A., Grigoriev, V. V., Koliasnikova, K. N., Zamoyski, V. L., & Seredenin, S. B. (2016). Neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors. Doklady Biochemistry and Biophysics, 471(1), 387–389. https://doi.org/10.1134/s160767291606003x
- Ostrovskaya, R. U., Vakhitova, Y. V., Kuzmina, U. S., Salimgareeva, M. K., Zainullina, L. F., Gudasheva, T. A., Vakhitov, V. A., & Seredenin, S. B. (2014). Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. Journal of Biomedical Science, 21(1). https://doi.org/10.1186/s12929-014-0074-2
- Zainullina, L. F., Ivanova, T. V., Sadovnikov, S. V., Vakhitova, Y. V., & Seredenin, S. B. (2020). Cognitive Enhancer Noopept Activates Transcription Factor HIF-1. Doklady. Biochemistry and Biophysics, 494(1), 256–260. https://doi.org/10.1134/S1607672920050129
- Ostrovskaya, R. U., Vakhitova, Y. V., Kuzmina, U. S., Salimgareeva, M. K., Zainullina, L. F., Gudasheva, T. A., Vakhitov, V. A., & Seredenin, S. B. (2014). Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. Journal of Biomedical Science, 21(1). https://doi.org/10.1186/s12929-014-0074-2
- Ostrovskaia, R. U., Gudasheva, T. A., Voronina, T. A., & Seredenin, S. B. (2002). [The original novel nootropic and neuroprotective agent noopept]. Eksperimental’naia I Klinicheskaia Farmakologiia, 65(5), 66–72. https://pubmed.ncbi.nlm.nih.gov/12596521/
- Ostrovskaya, R. U., Gudasheva, T. A., Zaplina, A. P., Vahitova, Ju. V., Salimgareeva, M. H., Jamidanov, R. S., & Seredenin, S. B. (2008). Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bulletin of Experimental Biology and Medicine, 146(3), 334–337. https://doi.org/10.1007/s10517-008-0297-x
