Why not unlock your brain’s full potential with Hydrafinil, the lesser-known yet powerful compound in the nootropic world? This compound has the potential to boost productivity and cognition.
Hydrafinil, also known as 9-Fluorenol, may help enhance focus, reduce daytime fatigue, and overcome sleep disorders. If you want to know more about this intriguing compound keep reading the blog.
In this blog, we’ll cover every aspect of the Hydrafinil. From what it is to how it works and its potential benefits to its recommended dosage, we’ll leave no stone unturned.
What is Hydrafinil?
Hydrafinil is a eugeroic compound, which means it promotes alertness and wakefulness. It is a derivative of Modafinil. Hydrafinil has a different spectrum of neurotransmitter interaction.
It is believed that the lipophilicity of Hydrafinil is higher than Modafinil. That means it may reach the brain to exert its effects readily and penetrate the blood-brain barrier easily. It may be more potent in reaching the brain to exert its effects [1].
A study published by Cephalon indicated that Hydrafinil was 39% more effective at keeping subjects awake for over 4 hours. [1]
After further investigation, it was determined that the eugeroic activity of the Hydrafinil analog was most probably due to an active metabolite, named fluorenol.
It is believed that Hydrafinil has a weak dopamine reuptake inhibitor, meaning it is less addictive than Modafinil. Hydrafinil’s less addictive quality makes it appealing to individuals who seek cognitive benefits without strong stimulation.
How Does Hydrafinil Work?
Hydrafinil works as a dopamine reuptake inhibitor (DRI) and a 5-HT6 receptor agonist. In simple words, Hydrafinil increases the dopamine levels in the brain by blocking the dopamine reuptake. Additionally, it may enhance serotonin and norepinephrine activity, which contributes to better mood and motivation.
Benefits Of Hydrafinil
Hydrafinil improves your cognitive abilities and helps you stay alert and active in conditions like stress or fatigue. Some of the other benefits of Hydrafinil are given below:
- Improve Focus
- Enhance Brain Power and Performance
- Help You Stay Awake and Alert
- Enhance Memory and Learning
Improve Focus
One of the primary benefits of Hydrafinil is that it increases dopamine levels in the brain. When dopamine levels are raised, it significantly boosts your ability to concentrate. With deep focus, alertness, and mental clarity, it becomes easier for you to handle your daily complex tasks. [1]
Enhance Brain Power and Performance
As Hydrafinil acts as a 5-HT6 receptor antagonist, it blocks the serotonin receptors. When the serotonin receptors are blocked, it influences various neurotransmitter levels, including choline. Increased Choline levels can contribute to improved cognitive function and brain performance.
Helps You Stay Awake and Alert
It’s important for you to stay alert and avoid drowsiness to manage your daily work tasks efficiently. Hydrafinil helps you stay active by raising the histamine levels in the brain. Histamine levels play a crucial role in regulating wakefulness.
Enhance Memory and Learning
Hydrafinil is believed to regulate glutamate levels. Glutamate is the prevalent excitatory neurotransmitter that supports the key brain functions in synaptic plasticity, learning, and memory.
Hydrafinil increases glutamate levels which helps in learning new information and improves cognitive functions related to memory and other tasks.
Improves Cognitive Function
Hydrafinil is majorly known for enhancing cognitive functions, including problem-solving, decision-making, and mental agility. Hydrafinil elevates norepinephrine levels, which helps you improve cognitive functions.
The enhanced cognitive function improves your cognitive performance and overall mental clarity. Plus it makes your mind sharp and lets you process information easily. [2]
Hydrafinil | Half-life and Appropriate Dosage
Since there is limited research on Hydrafinil due to its experimental nature there is no exact half-life and proper dosage available. However, some purported reports suggest the following half-life and dosage recommendations.
Half-life:
Hydrafinil’s half-life is not well-established due to limited studies. However, some users have reported that the compound has a shorter half-life of 4-6 hours. This shorter half-life means that it is removed from the body pretty fast.
Appropriate Dosage:
Hydrafinil is not FDA-approved and lacks clinical research [3] Therefore, the official dosage is yet unknown. Some users who experiment with it take between 50 to 100 mg per day. Another user reported that the dosage of Hydrafinil is as high as 200 mg.
Hydrafinil vs Adrafinil
Hydrafinil and Adrfinil are used to promote wakefulness and alertness. However, both work differently. As discussed above, Hydrafinil is a compound that works by inhibiting dopamine reuptake. It remains in the body for 4 – 6 hours and is considered milder as well.
Adrafinil itself is inactive in its original form when taken. It converts into modafinil after the metabolizing process in the liver. Adrafinil has longer-lasting effects. It stays in the body for up to 12 hours. Adrafinil is used widely and it has a more potent effect when compared to Hydrafinil.
Here is a table to represent the difference between Hydrafinil and Adrafinil:
| Properties | Hydrafinil | Adrafinil |
| Working process | Eugeroic compound, a derivative of Modafinil. Dopamine reuptake inhibitor (DRI) and 5-HT6 receptor agonist | Eugeroic compound, a prodrug that metabolizes into Modafinil |
| Half-life | According to users 4 – 6 hours | Approx 12 hours |
| Effect duration | Effects may be felt relatively quickly | Since it metabolizes into Modafinil first, its effects might take longer to be felt |
| Potency | Less potent and milder | More potent |
| Usage | Often used for cognitive enhancement | Used for wakefulness and alertness. |
| Approval status | Not FDA-approved and also lacks research | Not FDA-approved, but has broader research |
| Approx Dosages | Around 50 – 200 mg | Typically 300-600 mg per day, taken in divided doses |
Where to Buy Hydrafinil?
There are multiple places where you can buy hydrafinil. However, a few of the top places to buy Hydrafinil at cost-effective prices are given below:
| Vendors | Price | Customer Reviews | Verdict | Buying Link |
| Purerawz | $22.48 – $41.48 | 4.8/5 | Purerawz offers high-quality Hydrafinil with first and third-party testing. Customers praise their smooth shipping services. | Buy Hydrafinil from Purerawz |
| Science.bio | $49.99 | 4.6/5 | The vendor has been around for many years and is known for their reliable and high-quality products. | Buy Hydrafinil from Science.bio |
| RCD.bio | $36.48 | 4.7/5 | The best thing about this online shop is that it offers full transparency of its products. | Buy Hydrafinil from RCD.bio |
Summing Up:
Hydrafinil is a nootropic compound that enhances cognitive functions, particularly focus and alertness. It is used as a mild stimulant to promote wakefulness and mental focus without the harsh side effects often associated with other stimulants.
Reference
- PubChem. “9H-Fluoren-9-Ol.” Pubchem.ncbi.nlm.nih.gov, pubchem.ncbi.nlm.nih.gov/compound/74318
- Kovacs, J. (2024, June 26). Hydrafinil: Nootropic Benefits, Dosage, & Side Effects. WholisticResearch. https://wholisticresearch.com/hydrafinil/
- Research, Center for Drug Evaluation and. “FDA Approves Eflornithine for Adult and Pediatric Patients with High-Risk Neuroblastoma.” FDA, 14 Dec. 2023, www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-eflornithine-adult-and-pediatric-patients-high-risk-neuroblastoma
