According to studies, Semaglutide may take up to 48 hours to partially suppress appetite in users. For consistent appetite suppression, it takes approximately 4-5 weeks. This period varies from person to person, as multiple factors can influence the timeline.
For instance, the dosage quantity, dose frequency, and metabolic patterns of users can influence the timeline of Semaglutide’s effect on suppressing appetite in users. At the beginning of the Semaglutide journey, users may not experience appetite suppression. However, over time, appetite suppression becomes more noticeable, and users begin to feel fullness and reduced appetite between meals.
How Does Semaglutide Suppress Appetite?
According to the user’s experience, Semaglutide binds to GLP-1 receptors and influences the secretion of GLP-1 hormones. GLP-1 is an appetite-suppressing hormone released by the intestine in the body. The intestine releases GLP-1 during and after a meal. The release of GLP-1 suppresses appetite, induces a feeling of fullness, and reduces food cravings in users during the Semaglutide journey.
Appetite Suppression Timeline
The commonly observed timeline of appetite suppression by Semaglutide is as follows:
1-2 hours: (Absorption Starts)
This duration begins after Semaglutide is administered to users. During this period, the absorption of semaglutide starts gradually in the stomach and small intestine.
24 to 48 hours: (Peak Concentration of Semaglutide)
In this period, the absorption of Semaglutide reaches the highest point. Semaglutide also reaches the bloodstream and begins circulating within it. The early signs of appetite suppression also begin to appear. For instance, a user may start to feel full. Moreover, the patterns of insulin secretion are also impacted, regulating glucose levels in users. However, these signs are barely noticeable in this period.
1-2 weeks: (Noticeable Results of Appetite Suppression)
This is the period during which users begin to notice visible and consistent changes in appetite suppression. People may feel less hungry between meals. This helps reduce calorie intake and leads to natural weight loss. Additionally, effective glucose regulation also begins during this period. Some signs of diabetes-related issues may improve.
4-5 weeks: (Consistent and Steady Appetite Suppression)
This represents a more consistent period in the timeline of appetite suppression with Semaglutide. In this period, the presence of Semaglutide in people also reaches its highest levels. Appetite suppression becomes more noticeable. Appetite suppression may contribute to gradual weight reduction.
Factors Influencing Appetite Suppression Timeline
The timeline of appetite suppression by semaglutide varies from person to person. This is due to certain underlying internal and external factors. Here is a detailed explanation of these factors:
Dosage Frequency:
Dosage frequency is the first factor influencing the timeline of appetite suppression of Semaglutide. The higher the dose, the quicker the results of appetite suppression will be in users. In the case of a low dose, the results are likely to take time to appear in people. However, it is suggested to always follow the recommended dose and guidelines during your Semaglutide journey to achieve the desired results.
Metabolic Rate:
Another factor is metabolic patterns that may influence appetite suppression in users. A fast metabolic rate absorbs substances more quickly and then transports them to the specific body part where they are needed. If a person has a fast metabolic rate, they are more likely to experience appetite suppression more quickly than someone with a slow metabolic rate.
Underlying Health Conditions:
In the event of any underlying issue affecting users, it will impact the entire system, including the person’s metabolic rate. In the case of a disturbed metabolic system, the absorption rate of Semaglutide may fluctuate in users. This can lead to fluctuations in appetite suppression in people during the Semaglutide journey.
When Does Weight Loss Start on Semaglutide?
There is no universal timeline indicating when weight loss begins during the Semaglutide journey for users. This also varies from person to person based on various factors. For instance, some people start losing weight within a few days (8 to 10 days) of administering Semaglutide.
On the other hand, some individuals may take up to 4 to 5 weeks to start losing weight due to certain internal and external factors. In the context of this discussion, it is suggested that weight loss on Semaglutide varies from person to person.
Is Semaglutide a Long-term Solution for Appetite Suppression?
Semaglutide can suppress appetite temporarily. Such appetite suppression can range from months to years. This depends on the lifestyle patterns and choices of users. In case users get involved in unhealthy activities, the effects of Semaglutide can gradually disappear over time.
In this regard, many people also reported gaining weight after completing Semaglutide. Therefore, it is advisable to follow proper guidelines, consume a healthy diet, and engage in regular physical activity to maintain the effects of Semaglutide for a more extended period.
Final Thought
Semaglutide typically takes 4 to 5 weeks to suppress users’ appetite entirely. At the beginning of Semaglutide, the signs of appetite suppression are barely noticeable. However, over time, a research subject can observe noticeable results of Semaglutide, such as appetite suppression and weight loss. Such results are subject to various internal and external factors. These factors are the metabolic rate and health condition of users. Additionally, dosage frequency also affects the results of Semaglutide.
References:
- Blundell, John, et al. “Effects of once‐weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity.” Diabetes, Obesity and Metabolism 19.9 (2017): 1242-1251.
- Friedrichsen, Martin, et al. “The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity.” Diabetes, Obesity and Metabolism 23.3 (2021): 754-762.
- Gabe, Maria Buur Nordskov, et al. “Effect of oral semaglutide on energy intake, appetite, control of eating and gastric emptying in adults living with obesity: a randomized controlled trial.” Diabetes, Obesity and Metabolism 26.10 (2024): 4480-4489.
