Andarine (S4) Guide: Benefits, Dosage, Results & More!
Andarine, also known as S4, is a selective androgen receptor modulator (SARM) which increases muscle mass and shreds fat in users.
Initially developed by GTx Pharmaceuticals as a treatment for patients suffering from muscle loss, bodybuilders quickly caught on.
While it hasn’t been approved for human use by the FDA, body builders have been using Andarine (S-4) to build muscle mass and lose fat.
In this article, we’d like to explore the results, dosage, benefits, and more, pulled from clinical research studies and anecdotal user logs.
What is Andarine (S4)?
Andarine, also known by its research name S4, is a SARM that was initially developed to help treat patients suffering from musculoskeletal diseases.
Similar to other SARMs, Andarine is orally bio-available, and exerts a strong anabolic effect on the human body, encouraging lean muscle growth.
Andarine in particular was developed by GTx Pharmaceuticals, with the intent of using it to help treat muscle wasting conditions. [R]
Body builders quickly realized, however, that if a healthy individual takes a SARM like Andarine, their body will rapidly begin packing on muscle mass.
How Does Andarine Work?
Similar to other SARMs, such as Ostarine or Ligandrol, Andarine (S4) works by selectively binding to skeletal muscle androgen receptors in the body.
From here, it exerts a strong anabolic effect—in other words, it encourages lean muscle growth, rapid fat loss, and enhanced athletic performance.
It is for this reason some body builders take Andarine for its strong anabolic effects on the body, particularly when it comes to cutting.
In fact, recreational users report that Andarine allows them to rapidly cut off fat, and achieve the “cut and dry” look from just one 12 week cycle.
The main benefit of Andarine (S4) is its ability to help users build lean, dense muscle. This SARM is particularly useful for cutting, as well.
In fact, many recreational users have even compared the Andarine benefits to a low dose cycle of some steroids, like Anavar or Winstrol, for example.
Here are some benefits of Andarine (S4):
- Build Lean Muscle Mass
- Increase Bone Mineral Density
- Accelerate Body Fat Loss
- Create “Cut And Dry” Look
Many body builders love using Andarine for the “hard and dry” look that it gives the muscles, and claim that no other SARM can do this as well.
The above picture is of a user before and after a cycle of Andarine and Ostarine, and as you can see, their results are quite impressive.
Note the “hard and dry” look on the right—this is exactly why many body builders choose to take Andarine over other SARMs on the market.
Many users report Andarine results that are similar to steroids, such as losing 10-15 pounds of fat, while also gaining a 5-10 pounds of muscle.
Regardless, Andarine is an incredibly potent, muscle building SARM that is particularly good at shredding fat and getting lean during a cutting cycle.
Dosage & Cycle Guidelines
While there is no established therapeutic medical dosage of Andarine (S4), the general consensus is that most users do well on 25-100 mg per day.
The effects are dose dependent, meaning that the more you take, the better results you will get, but the more side effects you may experience.
Here are the best Andarine dosages:
- Beginner Dose: 25 mg per day
- Intermediate Dose: 50 mg per day
- Advanced Dose: 100 mg per day
Most users split their dosages up throughout the day, to maintain an even concentration in the blood, as Andarine has a 4-hour half life.
So, for example, an intermediate dosage of 50 mg Andarine per day would be equal to one full dropper per day of the Andarine from Proven Peptides.
Andarine Bulking & Cutting Stacks
Some users choose to take multiple SARMs at once, called a SARMs stack—this is done to get faster results, and enhance performance even more.
Andarine is typically best used for cutting, which is why recreational users often combine it with other cutting SARMs like Cardarine or Ostarine.
|Sample Bulking Stack||Sample Cutting Stack|
|Andarine – 25 mg per day||Andarine – 50 mg per day|
|Ligandrol – 20 mg per day||Cardarine – 20 mg per day|
|YK11 – 10 mg per day||Ostarine – 25 mg per day|
While Andarine (S4) is definitely more suited towards cutting, it can also be used on a bulking stack to stay lean and avoid any fat spillover.
Potential Side Effects
While there is no clinical data on the side effects of Andarine on humans, there is an ample amount of anecdotal user data we can learn from.
In addition to this, we can also assess the potential side effects of Andarine on humans by looking at the negative effects reported in animal studies.
Here are some potential side effects of Andarine:
- Testosterone Suppression
- Difficulty Seeing At Night
- Mild Liver Toxicity
- Decreased HDL Cholesterol
- Slightly Accelerated Hair Loss
Some users may experience more side effects than others, and some may experience no side effects it all—the reports of this vary wildly.
That being said, most recreational users report that the more serious side effects go away almost immediately after ceasing Andarine usage.
In conclusion, Andarine is a potent SARM that has very strong anabolic, muscle hardening effects, and is best used on a cutting cycle.
While it hasn’t been approved by the FDA for human use, Andarine is completely legal to buy online, for personal research purposes.
If you’re looking to buy 99% pure, 3rd party tested Andarine (S4), we recommend you get it from a good vendor, like Proven Peptides.
Every batch of their SARMs, are verified for purity by an independent lab, and if you use the code “nanotech” you’ll get 10% off your entire order.
❓ Is Andarine Good For Bodybuilding?
Andarine (S-4) is a very powerful SARM which bodybuilders love to use on a cutting cycle. Andarine is a great way to accelerate fat loss, and bodybuilders are known to use it when they want to get "cut and dry" right before a contest.
❓ How Does Andarine Work in the Body?
Andarine (S4) works by binding to androgen receptors in the skeletal muscle tissue, similar to other SARMs, shortly after ingestion. From here, it signals the muscles to start increasing protein synthesis, which leads to rapid muscle gain and fat loss.
❓ What is Andarine Used For?
While Andarine does help with building muscle, it's primarily used for cutting and recomposition (recomp) cycles. Users often report losing over 15 pounds of fat on an Andarine (S-4) cycle, and many users claim that Andarine helps them get the "shrink wrapped" cut and dry look that shows your muscle striations.
❓ What's The Best Andarine Dosage to Take?
While the Andarine dosage ranges from 25mg to 100mg per day, the best dosage for beginners is going to be 25mg to start. Anything over 50mg of Andarine per day and you'll start experiencing more side effects, so 25mg is a great place to start for fat loss and muscle building.
❓ Does Andarine Require A PCT?
Andarine, along with other SARMs, should be followed up by a good post cycle therapy (PCT) in order to get your natural testosterone levels back on track. Andarine isn't known for being as suppressive as other SARMs, but it's still a good idea to do a proper PCT after your cycle.