Agomelatine isn’t your typical antidepressant. Your standard antidepressant restricts itself to managing and treating depressive episodes. It doesn’t enhance your cognitive functions, improve your sexual health or create daylight between you and Alzheimer’s.
Agomelatine does all that and more. This atypical antidepressant also promotes neurogenesis or the creation of new brain cells and could thus promote learning and memory. It can even promote sleep quality and reduce hyperactivity in adults with autism.
Another thing distinguishes Agomelatine from first-line antidepressants, most of which have been shown to induce sexual dysfunction in their users. Fortunately, after taking this supplement, ½ as many users reported problems during sex than those using an SSRI.
This article will tell you everything you need to know about Agomelatine. We’ll kick things off by discussing what this supplement is and how it works in the body. Next, we’ll focus on the meaty part – the benefits of this drug and the dosage at which you can acquire them.
What is Agomelatine?
Agomelatine is a potent agonist of melatonin receptors and an antagonist of serotonin-2C receptors. It was initially developed in Europe in 1997. In 2005, it was submitted to the European Medical Agency (EMA), which approved it as a novel antidepressant in 2009.
In extensive clinical and preclinical studies, Agomelatine has displayed a broad-based profile of actions. Almost all of which add up to enhance this drug’s antidepressant activity. For instance, in one study, it reduced sleep disturbances, a symptom of major depression.
Another study reported that this supplement improves daytime functioning, preserves sexual function, and minimizes weight gain. Ask anyone who has ever been severely depressed, and they might tell that depression hurts daytime productivity, sex life, and weight.
Best of all, Agomelatine doesn’t cause withdrawal symptoms after discontinuation, a major side effect of typical SSRs. It also has a relatively long half-life (up to 2.5 hours) and good tolerability. All in all, this supplement has everything to treat major depressive disorder.
How Agomelatine Works?
Agomelatine works by increasing the activity of melatonin receptors. It also blocks the expression of serotonin-2C (5HTC) receptors. Both effects are crucial to this supplement’s potent antidepressant effects and its efficacy in treating major depressive disorder.
Melatonin receptors regulate circadian rhythms, whereas serotonin receptors influence anxiety, aggression, and mood. So, by agonizing the former and antagonizing the latter set of receptors, Agomelatine is almost guaranteed to alleviate depression symptoms.
In case you’re wondering, the antidepressant medications you see in medical stores work differently. Instead of targeting melatonin or serotonin receptors, those medicines act via the monoaminergic (monoamine) receptors. Hence why their side effects are much harsh.
A report prepared by the European Medicines Agency confirms the last statement. It mentions that when compared with standard antidepressants, Agomelatine poses a relatively small risk of severe side effects. This makes this supplement a much safer option to treat depression.
Agomelatine Benefits
Multiple preclinical and clinical studies point to various benefits of supplementing Agomelatine. These include reduced depression episodes, lower levels of anxiety, and enhanced mood. This drug can also restore sexual functions deteriorated by depression.
This supplement may also reduce your risk of Alzheimer’s disease. Preclinical studies have demonstrated that it could decrease three key markers of this life-altering condition. These include spatial memory deficits, amyloid-beta deposition, and brain inflammation.
Adults with autism, too, could benefit from this drug. A randomized clinical trial has shown that adults with autism spectrum disorder (ASD) experienced improved sleep patterns after receiving 25mg/day of Agomelatine for 25 days. That, too, with minimal adverse effects.
Here are the research-backed benefits of this supplement:
1) Alleviates depression symptoms
Agomelatine could treat depression and prevent relapse.
A meta-analysis of 20 trials showed that this supplement could match the antidepressant efficacy of selective serotonin reuptake inhibitors (SSRIs). [R]
A clinical trial not included in the above meta-analysis reported even better news: apart from treating depression, this supplement prevented relapse in 78% of the patients for up to 6 months.
2) Can relieve anxiety
Agomelatine relieves anxiety via a dual mechanism.
This supplement blocks the receptor in nerve cells – 5HT2C – that plays a key role in causing anxiety. At the same time, it increased the expression of another set of receptors – MT1 and MT2 – that are famous for keeping your anxiety levels in check. [R]
A preclinical study shows that the above effects aren’t just on paper. This drug’s anxiolytic effects have been reported to be as potent as Clorazepate, a clinically approved generalized anxiety disorder treatment. [R]
3) Improves cognitive functions
Agomelatine doesn’t just alleviate anxiety and depression.
Like Semax, it can also attenuate cognitive impairments caused by stress. This was shown in a study in which Agomelatine reversed memory impairments caused by chronic mild stress. [R]
Another preclinical study reported that this supplement enhanced memory performance and improved the learning index of treated animals, raising hopes that it could replicate these effects in humans. [R]
4) Enhances sleep quality
Agomelatine can improve your sleep quality in more ways than one.
In addition to enhancing slow-wave sleep (thought to be the most restorative sleep stage), this supplement can improve sleep wave quality. Aside from that, it can restore non-rapid-eye movement-rapid eye movement (NREM-REM) sleep stage cycles. [R]
Given the above effects, it shouldn’t be surprising to note that Agomelatine increases daytime alertness. What is surprising, though, is how quickly it does all that. A clinical trial has shown that depressed patients experienced all the above effects after just 1 week of taking this drug. [R]
5) May help people with autism
Agomelatine can help both children and adults with ASD.
According to a randomized clinical trial, this drug improved sleep disturbances (one of the major symptoms of autism) in 25 adults with this condition. [R]
A child with autism experienced reduced hyperactivity, sleep pattern disturbances, and irritability after being on this supplement for just three weeks. What is even more encouraging is that these improvements were well-maintained at week 12 after the drug’s use was discontinued. [R]
6) Restores sexual function in people with depression
It’s an open secret that depression can lower your libido.
What isn’t as well known is that the drugs used to treat depression can also hurt your libido. Worse, it isn’t only the high doses of antidepressant drugs that can hurt your sex drive. Low doses, too, can make it difficult for you to get in the mood. [R]
Depressed after reading all this? The novel melatonin agonist Agomelatine can get you out of this state of hopelessness and ensure your sexual health is optimal. Studies show that its usage is linked with a 50% lower rate of sexual dysfunction than standard SSRIs.
7) May lower your risk of Alzheimer’s
A preclinical study offers proof of the above statement.
This study reported that Agomelatine treatment reduced amyloid beta deposition and inflammation in the brain. This is significant as increased AB levels in the brain, as well as neuroinflammation, are one of the major causes of Alzheimer’s disease (AD). [R]
Agomelatine Results
Multiple users have shared their experiences with Agomelatine.
One such user claims that after taking 25 mg of Agomelatine every night for 30 days, his ‘sleep was completely restored’.
Another user cautions that Agomelatine didn’t cure his depression. Yet he states he ‘feels much better than any antidepressant’ he has ever been on.
Agomelatine Dosage
Research and anecdotal evidence indicate that 25 mg/day is the most effective dose.
The 25 mg dose has been proven to alleviate depression symptoms, restore sexual functions in depressed patients, and relieve anxiety associated with depression.
Continue with the dosage for two weeks and see whether you get the desired effects. If symptoms are not improved, increase to 50 mg, albeit with regular liver function rests.
The EMA recommends patients with depression continue Agomelatine dosage for at least six months. Only then can you expect this supplement to relieve all depression symptoms. [R]
How to Take Agomelatine?
Agomelatine is meant for oral use only.
It is suggested that this supplement can be taken with or without food. While it can be taken at any time of the day, taking this supplement at bedtime may give better results.
Where to buy Agomelatine?
Pure Rawz is the best place to buy Agomelatine online.
Pure Rawz provides reference materials with every product we sell. All of their products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
Pure Rawz also offers free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin.
Agomelatine Side Effects
Like all supplements, Agomelatine can cause side effects.
That said, most of this drug’s side effects are mild or moderate. They usually occur within the first fortnight of treatment and go away on their own.
In rare cases, the following side effects may occur:
- Dizziness
- Sleepiness
- Constipation
- Abdominal pain
- Abnormal dreams
- Increased ALT levels
Summary
Agomelatine increases the activity of melatonin and inhibits the expression of serotonin in the body.
Research has shown that it can alleviate depression symptoms with an efficacy comparable to that of SSRIs.
Agomelatine has also demonstrated the ability to relieve anxiety, improve cognitive functions, and enhance sleep quality. It may also lower your risk of Alzheimer’s and reduce hyperactivity in people with autism.