Semax Review: Benefits, Side Effects, Dosage & More (2024)

Semax Review: Benefits, Side Effects, Dosage

Semax was developed in Russia in the 1980s. It was initially used to prevent and treat circulatory disorders, such as strokes, heart attacks, and high blood pressure. The drug proved to be so effective that its researchers won the Prize of the Government of the Russian Federation in 2001.

Over the years, multiple small scale human trials have been conducted to examine its ‘nootropic’ or ‘cognitive enhancing’ potential. This is because the effects peptide Semax has on carboxypeptidase, an enzyme that performs various crucial functions in the human brain and body.

All these studies have proved one thing: Semax holds enormous potential as a cognitive enhancer drug. This peptide has been shown to improve memory, reduce stress and elevate mood. It has also been linked to enhanced clarity and reduction in brain fog.

The benefits of Semax aren’t limited to the brain. Animal models suggest that higher doses of Semax can increase physical performance, too, especially during high-intensity exercises. This means Semax can boost both mental and physical health.

What Is Semax?

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Semax, unlike PT 141, is a neuropeptide. It was initially developed to treat circulatory disorders such as heart attack, high blood pressure, and strokes. Over the years, though, its association with the adrenocorticotropic hormone(from which it is extracted) has elevated its reputation as a cognitive enhancer.

ACTH controls the production of cortisol, aka the stress hormone, in the body. This allows it to influence our mental capacities and determine how we respond in stressful situations. It also enables ACTH, and, by extension, Semax to regulate our memory, concentration, and mood.

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Yet another thing that is special about conventional Semax is that it boosts our motivation. It also primes our brain to help us get a grip on behaviors like procrastination and avoidance. Plus, in situations when we need to be more alert, Semax induces a controlled state of mental stress.

On top of everything else, this experimental drug helps reduce pain in your body. This, in turn, enables it to reduce inflammation and increase the cell of immune cell activity.

Overview of Benefits and Drawbacks

Let’s have a quick glance at the benefits and side effects of Semax nasal spray:


  • Prevents Oxidative Stress
  • Improves Cognitive Functions
  • Enhances Mood And Memory
  • Improves Blood Circulation
  • Might Treat Depression

Side Effects

  • Hair Loss

Since it’s a mild neuropeptide, side effects tend to be very rare with Semax use.

Semax Vs Selank: What’s The Difference?

While both were originally developed by the Institute of Molecular Genetics in Russia, there are at least two key differences between Semax and Selank.

  • Both are derived from different sources. While Semax is a small segment of ACTH, Selank is related to the immune system. It’s derived from t endogenous tetrapeptide Tuftsin, an immune system peptide that protects your immune system against viruses, bacteria, and tumors.
  • Both have starkly different uses. Semax is used in the prevention and treatment of circulatory disorders. Selank, on the contrary, was initially intended to be a neuropsychotropic and is used to treat opioid withdrawal, among other conditions.

When used together, Selank and Semax might improve the brain’s cognitive function, accelerate nerve regeneration, and improve both your immune and vascular systems.

How Does Semax Work?

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Semax works by chemically stimulating parts of the brain, including the hippocampus, the limbic reticular complex, and several receptors. Its effect on the receptors allows Semax to stimulate the release of the brain-derived neurotrophic factor (BDNF). That’s where things get interesting.

BDNF is responsible for ensuring the survival of neurons. It enhances the shelf life of your nerve cells by helping them in their growth, maintenance, and mutation. This protein also plays a crucial role in regulating synaptic plasticity, which is vital for memory and learning. [R]

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Various studies have shown that long-term stress decreases BDNF levels in the brain. This has led researchers to conclude that a decline in BDNF levels is linked to depression, aging and PTSD, conditions that Semax helps keep at bay by stimulating this neurotrophic factors’ release. [R]

Semax has also been shown to decrease the breakdown of enkephalins. Enkephalins are naturally-occurring peptides responsible for reducing the feelings of pain in the body. Their balanced levels are necessary for excellent brain health. [R]

Benefits of Semax

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Semax treatment helps improve memory, elevate mood and enhance learning powers. This nasal spray also increases your attention and improves mental clarity. You can count on it to improve brain function, reduce oxidative stress and reduce the risk of ischemic stroke.

Here are the major benefits of Semax:

  • Increased Motivation
  • Improved Mental Clarity
  • Enhanced Mood and Memory
  • Improved Blood Circulation
  • Might Treat Depression

Let’s expound on all these benefits.

1) Increased Motivation

Many people could do with a boost to their motivation levels. A recently concluded study has found that 8 percent of the world’s population is motivated enough to achieve their goals. The rest aren’t motivated enough to stick to the habits that could help them realize their dreams. [R]

Semax peptide might offer us a way out to motivate our motivation levels. This nasal spray can give you the nudge you need to achieve your goals by stimulating dopamine, the neurotransmitter that plays a vital role in reward-driven learning and, hold your breath, motivation. [R]

2) Improved Mental Clarity

Common sense tells us that mental clarity is essential for achieving your goals and improving your mental health. People whose minds are clear about their goals are much more likely to achieve the desired outcome. They are also more likely to get over failures and learn from their mistakes.

Most of you might be already aware of these facts. What the majority doesn’t know, however, is that Semax improves mental clarity. It does that by helping you keep your cool under stress, thereby making sure that when the going gets tough, you’ve what it takes to plod through. [R]

3) Enhanced Mood

In a news that would survive nobody, the COVID-19 pandemic has led to mood swings around the globe. More than a quarter of the people surveyed were either showing signs of, or were at risk for, a mood disorder, with youth’s mental well-being the hardest hit among people of all age groups. [R]

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Semax might offer us a way out of this mental health crisis. This experimental drug stimulates the release of dopamine, a neurotransmitter that, among other functions, also regulates mood. Dopamine’s influence on how you’re feeling is why people take dopamine supplements to boost their mood. [R]

4) Improved Memory

Memory problems are more common than you think. And it isn’t just the people aged 65 or older who are facing this problem. Population studies have found that around 14 percent of younger adults and 22 percent of older adults in the United States have memory complaints. [R]

Human clinical trials have shown that Semax might have what it takes to offer a solution to this predicament. Intranasal Semax administration to healthy men successfully stimulated their operative memory while also increasing resistance to hypoxia (a condition responsible for memory loss). [R]

5) Improved Blood Circulation

Proper blood circulation is vital for your health. When blood continuously flows throughout the body, your wounds heal faster, your heart stays healthy, and the brain remains sharp. Plus, good blood circulation also helps nourish skin cells by carrying away free radicals. [R]

Clinical research suggests Semax provides all these benefits. This experimental drug has been used successfully in the treatment of patients with impaired cerebral blood circulation. Its administration led to the improvement in the patients’ conditions, showing that Semax boosts blow flow. [R]

6) Might Treat Depression

According to an estimate, major depression affects 16 million American adults each year, which amounts to just under 6.7% of the population. This figure only takes into account the reported cases, with the actual number of people dealing with depression likely to be much higher. [R]

That’s where the bad news ends. One animal study has found Semax effective in enhancing the activity of dopamine and serotonin hormones in the brain. Both these hormones are known for their antidepressant properties. By increasing their levels, Semax might help treat depression. [R]

Side Effects of Semax

Side Effects of Semax

As is the case with any drug, Semax has its fair share of side effects. However, we might not be aware of this experimental drug’s entire safety profile. This means more research will be required to get a complete picture of the adverse effects Semax is capable of causing.

People with a chronic nervous system condition would do well avoiding Semax. The lack of clinical data on this experimental drug means we don’t know how it will react with any existing conditions. The same advice goes for patients who might be on other medications.

A few Semax users have reported hair loss. This complaint seems genuine because Semax stimulates the release of BDNF, which accelerates hair follicle growth, thereby promoting hair loss. Other than infrequent hair loss, we’re yet to come across any side effects of Semax, making it one of the best nootropics on the market right now.

Dosage & How to Take

Dosage & How to Take

The Semax dosage depends on which version of this drug you might be using. It is available in three versions: n-acetyl Semax (considered to be the strongest); n-acetyl Semax Amidate (highly bioavailable); and Adamax (new version).

Here are the user-recommended Semax dosage guidelines:

  • For Acetyl Version: Between 100 and 900 mcg
  • For Acetyl-amidate (NASA): between 200 and 900 mcg
  • Original Version: Between 50 mcg and 3 mg

The original, unmodified version is available in 20 mg vials that provide a 200 mcg dosage per spray. A single drop will be enough to experience effects. That’s because the original version is the strongest in terms of properties and how it stimulates neurotransmitters.

Keep in mind, though, that these are user-recommended guidelines. Multiple Semax reviews state that taking this synthetic peptide drug in the stated quantity did the job for them. If you’re confused, consult with your doctor before you start taking Semax.

Where To Buy Semax?

Where To Buy Semax?

If you’re unsure where to buy Semax, we recommend you purchase it from Pure Rawz.

All of PureRawz’s products come with a 30-day moneyback guarantee, 100-day satisfaction guarantee, and offer batch & lot tracking for seamless shipping.

PureRawz also provides you with third-party Batch Purity and Potency Audit reports of each and every one of their products, so you can’t have any doubts about their safety and efficacy.

For more information, you can read our full Pure Rawz review here.

Frequently Asked Questions

Frequently Asked Questions About Semax

Semax isn’t approved by the FDA and carries the status of ‘unscheduled drug’ in the United States. Unscheduled drugs can be bought without any doctor prescription. They can be sold from any retail outlet and their sale doesn’t require any professional supervision.

Does Semax need to be refrigerated?

Even though Semax comes in the form of a spray, it’s safe to be travel with and doesn’t require refrigeration after being opened. To increase its shelf life, it’s recommended that you store Semax away from light, heat and moisture.


Semax offers various sought-after benefits. This neuropeptide helps increase your motivation, enhance cognition functions, and improves mental clarity. You can also count on Semax to improve blood circulation throughout your body, thereby providing various other benefits.

That’s not all. Semax has also been shown to treat depression. It stimulates the release of hormones (dopamine and serotonin) which have known antidepressant properties. Any of you who is feeling glum has thus an extra incentive to use this drug.

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If you’ve liked what you’ve read about Semax, we recommend you buy it from a trusted vendor like PureRawz. When you buy any product from PureRawz, you’d get a 30-day moneyback guarantee, publicly available lab reports and a 100% satisfaction guarantee.

Keep in mind, though, that Semax is an unscheduled drug. This means its risk profile isn’t fully known. If you have any pre-existing medical conditions or are already taking any supplements, we suggest that you consult with your doctor before you start taking Semax nootropic.


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