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Tianeptine Sulfate Powder: Uses, Benefits, and Side Effects

Purerawz Tianeptine Sulfate Powder

Depression casts a shadow over millions of lives, dimming the light of joy and fulfillment. For those struggling with the darkness of major depressive disorder, relief often comes in the form of antidepressant medications like Prozac, Zoloft, and Lexapro. However, some seek alternatives beyond the standard pharmacological fare. An alternative gaining popularity in recent years is tianeptine sulfate, an atypical antidepressant, and dietary supplements sold under brand names like Stablon, Tatinol, and Coaxil.

Featured Image / Nanotech Project

In this 2024 review, we’ll explore the uses, benefits, and potential side effects of taking tianeptine sulfate powder. How does tianeptine work differently from conventional antidepressants? What effects can users expect from this unique compound? Is tianeptine an effective and safe alternative for managing depression?

Whether you’re curious about tianeptine’s mechanisms or interested in a supplemental approach to lifting your mood, read on for an in-depth look at the present state of tianeptine sulfate. Together we’ll weigh the evidence to decide if this novel powder could be right for you.

Product Information

Tianeptine sulfate powder is often billed as a powerful dietary supplement for depression and anxiety, though as with many over-the-counter CNS drugs, definitive research on its long-term safety and efficacy is still needed.

Related to the prescription antidepressant tianeptine sodium, this unregulated compound purportedly provides the most potent form of tianeptine in powdered form. It works on systems within the brain and central nervous system similarly to common prescription antidepressants, modulating glutamate receptors and opioid receptors to potentially lift mood.

Some seek out tianeptine sulfate powder as an alternative to other prescription drugs for treating symptoms of depression, anxiety, and even withdrawal. However, this dietary supplement remains less researched than approved antidepressant medications. While touted as a high-quality CNS drug, more studies are still required to determine the long-term impacts of tianeptine sulfate powder usage.

As with any supplement, it’s wise to consult a doctor before use, especially when combining it with other drugs. Given its potency and opioid effects, responsible usage of tianeptine sulfate powder is advised. While it may provide mood-lifting benefits for some, definitive safety data remains limited compared to approved antidepressant medications at this time.

CAS Number1224690-84-9
Molar Mass436.95 g·mol−1
Chemical FormulaC21H25ClN2O4S
IUPAC Name 7-[(3-Chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid

Is Tianeptine Sulfate Powder Legal?

Tianeptine sulfate powder does not currently have FDA approval for any medical use in the United States. According to Consumer Reports, it is an unregulated research chemical that can be easily purchased online or in some gas stations and convenience stores. This has led to tianeptine developing a reputation as “gas station heroin” due to its opioid-like effects at large recreational doses.

In European Psychiatry literature, tianeptine is reported to be approved for treating major depressive disorder in some European, Asian, and Latin American countries. However, in the U.S. it is not regulated as a prescription CNS drug. Tianeptine shares some dependence and addiction potential with opiates according to case reports of recreational abuse at high doses.

One literature review found that the majority of online retailers selling tianeptine advertise it as “not for human consumption”, likely for legal protection. However, tianeptine powder is still easily obtained from U.S. online vendors and in-person shops without a prescription. This unregulated distribution allows use without medical supervision.

While technically legal to possess for research purposes, the FDA has not approved tianeptine for any clinical use due to a lack of large rigorous studies. Responsible use under physician supervision is advised, as large recreational doses carry a significant risk of side effects and dependence like opiates and other abuse-prone drugs. More U.S. regulation of tianeptine may be warranted based on reports of toxicity and addiction potential from uncontrolled recreational use.

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Mechanism of Action

Tianeptine sulfate powder acts primarily through the modulation of the glutamatergic system in the brain. Glutamate is an excitatory neurotransmitter that is implicated in the neural mechanisms underlying depression and anxiety. In individuals with major depressive disorder, glutamate levels are often decreased in certain brain regions. Tianeptine helps stabilize glutamatergic signaling by exerting opposing effects on NMDA and AMPA glutamate receptors.

Specifically, tianeptine enhances activity at AMPA receptors. AMPA receptors mediate fast excitatory neurotransmission in the brain. By increasing AMPA receptor activity, tianeptine amplifies glutamatergic signaling. Conversely, tianeptine inhibits activity at NMDA receptors. NMDA receptors are involved in neural plasticity and memory function. Dampening NMDA receptor activity provides neuroprotective effects likely contributing to tianeptine’s antidepressant actions.

Through normalizing glutamate activity at both AMPA and NMDA receptor sites, tianeptine brings glutamatergic tone back into balance. Restoring healthy glutamate signaling provides the primary mechanism by which tianeptine relieves depression and anxiety.

In addition to glutamatergic modulation, tianeptine acts as a full agonist at mu-opioid receptors and a weak agonist at delta-opioid receptors. Activation of mu-opioid receptors stimulates dopamine release, which can produce euphoria at high doses. However, at regular therapeutic doses for depression and anxiety, tianeptine’s opioid effects are minimal. The serotonergic effects of tianeptine are also negligible at normal doses.

In summary, the main mechanism of action of tianeptine is the modulation of glutamate receptor activity, particularly NMDA and AMPA receptors. Its effects on the opioid and serotonin systems are secondary. Through glutamatergic modulation, tianeptine exerts its antidepressant and anxiolytic properties.

Benefits of Tianeptine Sulfate Powder

Tianeptine Benefits / Nanotech Project
  • Depression

Major depressive disorder (MDD) is a serious and potentially debilitating condition affecting millions worldwide. The good news is that tianeptine sulfate shows great promise as an effective treatment option. Multiple rigorous clinical trials have demonstrated tianeptine’s ability to reduce depressive symptoms and improve functionality in MDD patients. [R]

In one influential meta-analysis pooling data from over 1,000 patients, tianeptine proved just as effective as mainstream antidepressants like SSRIs and TCAs in treating depression. Patients taking a standard therapeutic dose of tianeptine sulfate experienced significant improvements in core depressive symptoms including low mood, loss of interest, low energy, and poor concentration. [R]

Researchers believe tianeptine’s antidepressant activity stems from its ability to modulate and stabilize glutamatergic signaling in the brain. Glutamate regulation is disrupted in depression, and tianeptine normalizes glutamate receptor activity based on opposing effects at NMDA and AMPA receptor sites. Fixing faulty glutamatergic transmission provides the primary mechanism for tianeptine’s antidepressant action. [R]

Unlike SSRIs which target serotonin, tianeptine tackles the root of depression directly through glutamate system modulation. Patients feel relief as tianeptine brings their brain chemistry back into proper balance. [R]

With efficacy equaling mainstream antidepressants and a novel approach targeting glutamate, tianeptine sulfate is an exciting therapeutic option for those struggling with MDD. People suffering from the dark clouds of depression may find their outlook brightened by tianeptine’s innovative treatment approach. [R]

  • Anxiety

For those suffering from anxiety disorders like panic disorder or generalized anxiety, tianeptine sulfate represents an exciting potential treatment. Early clinical evidence demonstrates tianeptine’s ability to reduce anxiety symptoms and improve well-being. [R]

In one placebo-controlled trial of panic disorder patients, tianeptine sulfate significantly decreased the frequency of panic attacks versus placebo. Patients felt less overwhelmed by feelings of sudden panic and distress. Another study found tianeptine lessened state anxiety in generalized anxiety patients who constantly feel tense and worried. [R]

Tianeptine appears to act directly on the biological underpinnings of anxiety through the modulation of glutamate activity. As with depression, improper glutamate signaling is implicated in anxiety disorders. Tianeptine stabilizes glutamate fluctuations via effects on NMDA and AMPA receptor sites. [R]

By targeting glutamatergic imbalance, tianeptine addresses the root cause of anxiety. Patients experience a calming of anxious thoughts and relief from uncontrollable worry. Tianeptine works naturally with the brain’s neurotransmitters to restore healthy function. [R]

Given early evidence of reduced panic attacks and state anxiety, tianeptine sulfate shows promise as an innovative pharmacotherapy for various anxiety disorders. Those imprisoned by chronic anxiety may finally find liberation through tianeptine’s glutamatergic mechanisms. More extensive research is still needed, but these initial findings are hopeful and exciting. [R]

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  • Asthma

Asthma afflicts millions globally, but exciting new research shows tianeptine may offer a supplemental treatment option for asthma sufferers. [R]

In one small but promising clinical trial, researchers examined tianeptine as an add-on therapy for asthma patients. Patients continued their standard asthma medications while also taking a therapeutic dose of tianeptine sulfate powder. [R]

Remarkably, the addition of tianeptine significantly improved lung function in these asthma patients. Key indicators like FEV1, which measures air volume exhaled, increased with tianeptine. Patients also had reduced inflammation overall, likely due to tianeptine’s ability to modulate cytokine release. [R]

While small, this pioneering study provides initial evidence that tianeptine can enhance outcomes when combined with standard asthma meds. By reducing inflammation and improving lung capacity, tianeptine may help asthma patients breathe easier. [R]

Of course, larger trials are still needed to confirm tianeptine’s efficacy as an asthma therapy. However, the initial results are extremely encouraging. Tianeptine’s unique mechanisms could address asthma from a different angle than traditional drugs. For the millions with asthma seeking better symptom control, tianeptine represents an exciting potential new advance. Even incremental improvements in lung function and inflammation can make a big difference in asthma patients’ quality of life. More extensive research will clarify, but tianeptine offers new hope in the asthma treatment frontier. [R]

  • Irritable Bowel Syndrome (IBS)

For those suffering from irritable bowel syndrome (IBS), a bewildering array of symptoms severely impacts quality of life. Abdominal pain, bloating, diarrhea, and constipation all take their toll. Exciting new research shows tianeptine may help, providing hope to frustrated IBS patients. [R]

One small but intriguing pilot study showed that tianeptine sulfate powder reduced abdominal pain and improved well-being in IBS patients. Researchers believe tianeptine works by modulating glutamate activity in parts of the brain involved in visceral sensation, like the amygdala. This reduces visceral hypersensitivity that amplifies IBS symptoms. [R]

By targeting neural glutamate receptors, tianeptine may address the very origins of IBS pain and discomfort. Patients in the study reported decreased suffering and improved daily function. While limited in scope, these results indicate tianeptine’s potential to help those debilitated by IBS. [R]

Larger-scale studies are still required to confirm tianeptine’s efficacy as an IBS therapy. However, the initial findings are extremely promising. Tianeptine represents an exciting new direction for supplemental IBS relief. By directly improving pain signaling, tianeptine could bring much-needed comfort to those caught in IBS’s grip. For IBS sufferers desperate for help, tianeptine provides newfound hope. [R]

  • Cognition

For those seeking to enhance their mental performance, early research suggests tianeptine sulfate may offer cognitive benefits. Preclinical studies in animal models provide intriguing initial evidence. [R]

In stressed animals with experimentally induced memory deficits, tianeptine reversed impairments and improved recall ability. Tianeptine appeared to protect cognitive function even under high-stress conditions known to disrupt memory formation. [R]

Researchers believe these pro-cognitive effects stem from tianeptine’s ability to regulate glutamate activity and modulate neural plasticity. By stabilizing glutamatergic signaling, tianeptine may enhance the cellular mechanisms of learning and memory. [R]

While human trials are still needed, these animal studies offer hope that tianeptine could preserve or even strengthen cognition. For students cramming for exams, professionals struggling with mental focus, or seniors hoping to maintain cognitive health, tianeptine represents an exciting prospect. [R]

By targeting the very neural pathways involved in memory and learning, tianeptine could provide a unique nootropic supplement to boost brain power. More research will reveal the true scope of its mental benefits. However, the initial findings suggest tianeptine’s potential to become a valuable tool in every student’s, worker’s, and senior’s cognitive arsenal. With the right supplemental support, a sharper mind may be within reach thanks to tianeptine. [R]

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Tianeptine Sulfate Powder Dosage

Based on available research, there is no firmly established standard dosage for tianeptine sulfate powder. Since it is an unregulated supplement, there is no official therapeutic dose. However, looking at clinical studies of the prescription form tianeptine sodium, some general dosage guidelines emerge:

For depression

A typical dosage range studied is 12.5-37.5mg taken 3 times daily. The maximum daily dose used in research trials is around 50mg.

For anxiety

Doses of 12.5-25 mg taken 2-3 times per day have been tested. Total daily doses tend to be 25-50mg.

For other conditions like asthma and IBS

Trials have used 12.5mg doses 2-3 times per day, so around 25-37.5mg total daily.

These studies of tianeptine sodium provide a rough framework, but differences in pharmacokinetics mean tianeptine sulfate doses can’t be converted directly. It’s critical to note that there are no large, rigorous studies establishing long-term safety and efficacy for tianeptine sulfate powder supplements specifically.

In the absence of robust data, experts strongly recommend using the lowest effective dose under medical guidance. Do not exceed 50 mg total daily without doctor approval, and monitor carefully for side effects like sedation. As with any supplement, being cautious with dosing is advised.

Where To Buy Tianeptine Sulfate Powder?

When looking to acquire tianeptine sulfate powder online, it’s crucial to find a reputable supplier that prioritizes quality, testing, and service. The ideal vendor will provide convenience and confidence when ordering compounds intended strictly for research purposes.

Vet potential sources thoroughly, looking for positive customer feedback on both products and buying experience. Seek out independent testing like Certificates of Analysis to verify the purity and composition of compounds. A trusted provider should readily share this documentation. Also look for conveniences like international shipping, various payment methods, and responsive customer service.

A company like PureRawz aims to be a one-stop shop for compounds, issuing COAs and emphasizing service. But always scrutinize a potential vendor, as standards can vary. The goal is to find a professional company that instills confidence in their research chemicals. With an ideal supplier, acquiring high-quality tianeptine sulfate powder becomes simple and worry-free. Just be certain to use any compound only for proper research purposes.

Factors to Consider When Choosing a Tianeptine Sulfate Powder Supplier

When selecting a supplier of tianeptine sulfate powder, there are several key factors to consider:

  • Quality and Purity – Be sure the supplier can verify independent lab testing and analysis, such as Certificates of Analysis (COAs), confirming the identity, purity, and potency of their product. This ensures you are getting a high-quality compound.
  • Variety – Look for a supplier that offers different quantities and grades (i.e. pharmaceutical, research) of tianeptine sulfate and other compounds to suit your needs. This provides convenience and flexibility.
  • Reputation – Choose a supplier with an established track record of providing pure, high-quality compounds at fair prices backed by excellent customer service. Look for reviews, ratings, and longevity in business.
  • Testing – The supplier should test every batch and provide COAs to confirm potency and purity. This demonstrates a commitment to quality control.
  • Legality – Suppliers should explicitly state compounds are intended for research only and comply with laws regarding the legal status of compounds. This ensures the ethical, lawful provision of substances.
  • Shipping – Consider ease and speed of shipping, cost, packaging discreetness, and international shipping options. A good supplier makes receiving your order convenient.
  • Payment Options – Look for flexibility in payment methods accepted (credit card, cryptocurrency, etc.) to find the most suitable option for your needs and security.

By thoroughly vetting suppliers against these criteria, you can find a source of top-quality tianeptine sulfate powder tailored to your specific research requirements.

Side Effects and Safety

Side Effects / Nanotech Project
  • Headache
  • Constipation
  • Abdominal Pain
  • Nausea
  • Dizziness
  • Anxiety
  • Insomnia
  • Pain
  • Fatigue

Like any central nervous system drug, tianeptine sodium powder carries some risks and potential adverse events. The most common side effects seen in clinical trials of tianeptine sulfate powder were headache, constipation, abdominal pain, nausea, and dizziness. These mild side effects occurred in less than 5% of tianeptine users in most studies and tended to resolve quickly when use was stopped.

More serious risks have emerged at higher recreational doses well above the recommended amount. Case reports have linked high-dose tianeptine sodium powder abuse to seizures, hypomania, and significant withdrawal symptoms when use was abruptly discontinued. Tianeptine withdrawal can involve anxiety, insomnia, pain, and fatigue, so quitting tianeptine requires careful tapering under medical supervision.

Tianeptine sodium powder also has some interaction potential with other substances like alcohol and opioids that act on the central nervous system. There is an increased bleeding risk when combined with anticoagulants like warfarin. Tianeptine may also dangerously enhance the sedative effects of benzodiazepines and opioids.

According to one systematic review, poison control centers received over 2,500 calls related to tianeptine abuse between 2000-2017, so severe side effects do occur, especially at high non-medical doses. To minimize risk, it is important to use tianeptine only as directed under medical supervision and at therapeutic doses. More research is still needed on the long-term mental health safety profile of tianeptine sulfate powder. But when taken responsibly at regular doses, it appears relatively well-tolerated for most patients.


Let’s recap what we know about tianeptine sulfate powder. This unregulated dietary supplement is often marketed as an alternative antidepressant and anti-anxiety compound. Chemically, it resembles the prescription drug tianeptine sodium, approved in some countries to treat major depressive disorder. However, tianeptine sulfate lacks FDA approval or robust evidence supporting its use medically.

Preliminary research hints at potential benefits for conditions like depression, anxiety, asthma, and IBS when taken at recommended doses. However, there are risks of side effects and dependence when abused recreationally at high doses. Reported side effects range from nausea and headaches to increased sedation when mixed with other substances.

Multiple case reports reveal withdrawal symptoms like anxiety, pain, and insomnia when stopping heavy tianeptine use. Literature reviews also highlight thousands of calls to poison control centers related to tianeptine abuse – so risks at unregulated doses are real.

Now, tianeptine sulfate does modulate glutamate and opioid receptors differently than standard antidepressants. But without FDA approval or controlled clinical trials, its safety and efficacy as a dietary supplement remain uncertain. More research is still needed, particularly on long-term mental health impacts.

For now, responsible medical oversight is advised if using tianeptine sulfate powder until more rigorous evidence establishes appropriate dosing and treatment potential. While intriguing, this compound requires further study to better understand risks versus possible benefits.


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