Sermorelin Review – Benefits, Side Effects, Dosage, and More
Sermorelin is a growth hormone secretagogue (GHS), meaning it enhances growth hormone (GH) secretion in the pituitary gland. This enables it to raise testosterone levels, increase muscle mass and height, enhance sexual desire, and improve heart health.
Is it any wonder then that bodybuilders have been taking and using this new fascinating compound in order to get an edge in competition and look better? A drug like Sermorelin will help you build lean muscle mass, increase growth hormone, shred fat, and much more.
This article will tell you everything you need to know about Sermorelin. We’ll kick things off by explaining what this GH secretagogue is and how it works. Next, we’ll discuss the benefits of Sermorelin as well as the dosages at which you can hope to acquire them.
What is Sermorelin?
Sermorelin is a growth hormone-releasing hormone (GHRH) analogue. It is isolated from the first 29 amino acids of the GHRH protein and is thus also known as GHRH (1-29). Its mechanism of action (explained below) distinguishes Sermorelin from other growth hormone secretagogues. [R]
Sermorelin was developed to treat children with GH retardation. Initial clinical trials reported such positive results that the US FDA approved Sermorelin for the same use. While the approval has since been retracted, physicians still use it to diagnose GH deficiency in adults. [R]
Similar to MK-677, Sermorelin was also developed for the same reasons. These compounds will both act on your ghrelin receptors and increase growth hormone in the body, making them great options.
How does Sermorelin Work?
Sermorelin stimulates the production of GHRH via the hypothalamic-pituitary-somatotropic axis. GHRH is responsible for increasing human growth hormone (HGH) secretion in the pituitary gland. Thus, by increasing the production of GHRH, Sermorelin therapy raises HGH levels. [R]
HGH, in turn, offers various benefits. Its increased secretion has been proven to increase bone density, reducing your risk of fractures and osteoporosis. HGH also increases muscle mass and reduces body fat, so you can count on it to help your body look lean and more athletic. [R]
That said, like everything else in life, excess of HGH is bad. High levels of human growth hormone have been shown to produce irreversible acromegaly, a condition characterized by abnormally large hands and feet. So it’s crucial that your HGH levels increase within a safe range. [R]
Which is precisely what Sermorelin, or, to be more precise, somatostatin ensures. Somatostatin is an inhibitory neurohormone that regulates the effects of Sermorelin. It makes it difficult, if not outright impossible, for Sermorelin to cause an overdose of HGH in the body. [R]
Since it was initially developed in the 1990s, Sermorelin has attracted various clinical trials. Unsurprisingly, these studies have shown that Sermorelin can raise GH levels. Sermorelin has also been shown to increase height, enhance lean body mass, and reduce body fat.
Here are the various potential benefits of Sermorelin:
1. Enhances GH secretion
Multiple studies have shown that Sermorelin is capable of increasing HGH levels.
One study involving short-height children reported that the increases Sermorelin promotes in GH levels are similar to those observed with endogenous GHRH. A 1 mcg/kg dose produced this effect. [R]
Another study investigated the effects of Sermorelin treatment in adults. Final results indicated that Sermorelin could increase GH and reverse the age-related decrease in GH levels. This suggests that prolonged treatment with this peptide can help you age better [R]
2. Increases lean body mass
Sermorelin might also help you look more athletic.
That is according to a double-blind placebo-controlled trial in which this peptide increased lean body mass by 1.25 grams in men. The trial involved nine men and ten women between 55 and 71 years old who were given 10 µg/kg of Sermorelin for 16 weeks (4 months). [R]
3. Might make you taller
Two clinical studies have shown that Sermorelin might increase body height.
In the first study, 30 micrograms/kg Sermorelin was proven to be effective in increasing height velocity (increase in height during a specific period) in GH-deficient children. The second study reported increased linear growth in children who were NOT GH-insufficient. [R][R]
4. Increases sexual drive (libido)
One study has shown that Sermorelin might also make you a better performer in bed.
According to this clinical, men who underwent Sermorelin treatment for 16 weeks reported significant improvements in libido as well as general well-being. What’s equally encouraging is that the only side effect, transient hyperlipidemia, automatically resolved by the study’s end. [R]
5. Raises IGF-1 levels
Insulin-like growth factor 1 is a hormone that manages the effects of GH in your body. Equally importantly, it regulates muscle regeneration, protects your brain, and helps with body growth. [R]
Fortunately, Sermorelin has been proven to increase IGF-1 levels in adults. The study which reported that Sermorelin increased IGF-1 levels included young men (22 – 33 years of age) and the elderly (60 – 78 years of age). This means you don’t have to be of a specific age to acquire this benefit. [R]
6. Enhances muscle endurance
Reduced muscle endurance is one of the biggest signs of aging. It also contributes to a variety of negative outcomes, such as an increased risk of falls, fractures, and even hospitalization. [R]
A clinical study has reported that Sermorelin is capable of improving abdominal crunch. This is relevant as abdominal crunch is one of the biggest indicators of muscle endurance. As such, you may count on Sermorelin to help your muscles retain their normal physiology during the aging process. [R]
7. Reduces body fat
As noted above, Sermorelin might help you look leaner.
This was proven by a study in which Sermorelin treatment induced a significant decrease (up to 5%) in men’s body fat percentage. This change happened after once-daily Sermorelin injections for an extended time period. [R]
A dosage of 1mcg per kg of bodyweight daily by subcutaneous injection at bedtime is recommended. Make sure to rotate injection sites periodically to avoid swelling. You can cycle Sermorelin for 8 to 12 weeks to get the desired results. However, if you experience any unwanted changes, discontinue the use.
If you weigh 100kg, take 100mcg or 0.1mg per day. If you weigh 75kg take 75mcg or 0.075mg per day, and so on. For easy convenience, you can also just follow this dosage protocol:
- Beginner Dosage: 50mcg per day
- Intermediate Dosage: 75mcg per day
- Advanced Dosage: 100mcg per day
We recommend you always start off with lower dosages to assess your tolerance.
Sermorelin Side Effects
Sermorelin appears to be well-tolerated by most users. However, as with any drug, it’s possible to have an allergic reaction to this synthetic peptide. It’s crucial that you know about your allergies before taking this drug or any drug for that matter.
Some users may experience rare side effects, such as:
- Difficulty Swallowing
Most people tolerate Sermorelin very well, but there are obviously the odd individuals that don’t tolerate it well at all. This is why you should start off at a small dosage and assess your tolerance first.
In summary, Sermorelin has been proven to increase growth hormone and IGF-1 levels, reduce body fat, and increase sexual desire. It may also keep various aging symptoms at bay, such as reduced muscular endurance and decreased insulin-like growth factor 1 levels.
This makes it a wonderful drug that users can take to increase lean muscle mass and totally transform their physiques in just a month or two. I had great results on Sermorelin personally.
If you are interested, we recommend you check out the Sermorelin for sale from PureRawz and use the code “MD15” for 15% off your entire order (not just if you buy Sermorelin).
Of course, if you have any questions, let us know in the comments section down below and we’ll do our best to get back to you and help you out.
❓ Why Was Sermorelin Developed?
Sermorelin was initially developed to treat human growth hormone deficiency in children. For several years, it was approved by the FDA to treat this condition.
❓ What is Sermorelin Good For?
Human studies have shown that Sermorelin can stimulate growth hormone release from the pituitary gland. It can also enhance sexual desire (libido) and help you put on more lean body mass. It has also been shown to induce skin elasticity and improve immune function.
❓ Can Sermorelin Improve Cognition?
A clinical study involving adults reported that Sermorelin exerted beneficial effects on the participants' cognitive performance. This shouldn't come as a surprise, given that other studies have also linked GHRH treatment to improvement in cognitive performance.
❓ Does Sermorelin Burn Belly Fat?
While it remains unknown whether Sermorelin peptide therapy can target belly fat, research has shown that this peptide can decrease overall body fat by as much as 5% in men.
❓ Does Sermorelin Interact With Any Drug?
Complete data on possible drug interactions of this peptide isn’t available. It’s thus recommended to talk to your doctor before you start taking Sermorelin acetate.