Do you know Semax is a powerful peptide, and also a brain-boosting nootropic! As a peptide, Semax might show neuroprotective properties, and as a nootropic, it might aid in improving cognitive functions such as memory, focus, and learning.
Are you curious to learn more about this interesting compound? Keep reading the blog. In this blog, we’ve gathered important information regarding Semax.
We’ll discuss everything about Semax from how it works to its potential benefits, side effects, and dosage guidelines.
What is Semax?
Semax is a neuropeptide that was initially developed to treat circulatory disorders such as heart attack, high blood pressure, and strokes. It was also used to support brain health and cognitive function.
Semax is derived from the short peptide fragment of the adrenocorticotropic (ACTH) hormone, particularly the ACTH (4-10) sequence. ACTH’s primary goal is to stimulate the adrenal glands to produce cortisol.
You might think that Semax also stimulates cortisol release. Well, it does not release cortisol. That is because the ACTH fragment is modified to sustain the cognitive benefits without triggering a cortisol release.
Another thing that is special about conventional Semax is that it boosts motivation. It also primes the brain to help get a grip on behaviors like procrastination and avoidance. Plus, in situations when we need to be more alert, Semax induces a controlled state of mental stress.
How Does Semax Work?
Semax works by chemically stimulating parts of the brain, including the hippocampus, the limbic reticular complex, and several receptors. Its effect on the receptors allows Semax to stimulate the release of the brain-derived neurotrophic factor (BDNF). That’s where things get interesting.
BDNF is responsible for ensuring the survival of neurons. It promotes the longevity of your nerve cells by helping them in their growth, maintenance, and mutation.
This protein also plays a crucial role in regulating synaptic plasticity, which is vital for memory and learning. [1]
Various studies have shown that long-term stress decreases BDNF levels in the brain. This has led researchers to conclude that a decline in BDNF levels is linked to depression, oxidative damage, aging, and PTSD, conditions that Semax helps keep at bay by stimulating these neurotrophic factors’ release. [2]
Semax has also been shown to decrease the breakdown of enkephalins. Enkephalins are naturally occurring peptides responsible for reducing the feelings of pain in the body. Their balanced levels are necessary for brain health. [3]
Potential Benefits of Semax
Semax might help improve memory, elevate mood, and enhance learning powers. The compound also increases attention and improves mental clarity. Here are some other major benefits associated with Semax:
- Might Increase Motivation
- May Improve Mental Clarity
- May Enhance Mood and Memory
- Might Improve Blood Circulation
- Might Treat Depression
Might Increase Motivation
Semax peptide might offer a way out to enhance motivation levels. It might give you the nudge you need to achieve your goals by stimulating dopamine. Dopamine is the neurotransmitter that plays a vital role in boosting mood and motivation. [4]
May Improve Mental Clarity
Semax improves mental clarity by influencing neurotransmitter systems and improving neuroprotection. Moreover, it enhances the levels of (BDNF), which helps neurons to grow and survive which ultimately leads to improved cognitive functions such as memory and mental clarity.
May Enhance Mood
Semax might offer a way out of a mental health crisis. This experimental drug stimulates the release of dopamine, a neurotransmitter that helps regulate mood.
Might Improve Memory
Memory problems are more common than you think. And it isn’t just the people aged 65 or older who are facing this problem. Population studies have found that around 14 percent of younger adults and 22 percent of older adults in the United States have memory complaints. [5]
Human clinical trials have shown that Semax might have what it takes to offer a solution to this predicament. Intranasal Semax administration to healthy men successfully stimulated their operative memory while also increasing resistance to hypoxia (a condition responsible for memory loss). [6]
May Improve Blood Circulation
Proper blood circulation is vital for your health. When blood continuously flows throughout the body, your wounds heal faster, your heart stays healthy, and the brain remains sharp. Plus, good blood circulation also helps nourish skin cells by carrying away free radicals.
Clinical research suggests that Semax provides all these benefits. This experimental drug has been used successfully in the treatment of patients with impaired cerebral blood circulation. Its administration led to an improvement in the patient’s condition, showing that Semax boosts blood flow. [7]
Might Treat Depression
One animal study has found Semax effective in enhancing the activity of dopamine and serotonin hormones in the brain. Both these hormones are known for their antidepressant properties. By increasing their levels, Semax might help treat depression.
Side Effects of Semax
As is the case with any drug, Semax has its fair share of side effects. More research will be required to get a complete picture of the adverse effects Semax is capable of causing. However, a few of the side effects that users have reported are given below:
- Irritability or Agitation
- Insomnia
- Increased Blood Pressure
Dosage Recommendation & Guidelines
The Semax dosage depends on which version of this drug you might be using. It is available in three versions:
- n-acetyl Semax (considered to be the strongest);
- n-acetyl Semax Amidate (highly bioavailable);
- Adamax (new version).
Here are the recommended Semax dosage guidelines:
- For Acetyl Version: Between 100 and 900 mcg
- For Acetyl-amidate (NASAL): between 200 and 900 mcg
- Original Version: Between 50 mcg and 3 mg
Disclaimer:
The information provided is for informational purposes only and should not be considered medical advice. Readers should consult with a healthcare professional before using Semax or any other supplement.
Where To Buy Semax?
If you’re unsure where to buy Semax, we recommend you buy Semax from the following vendors.
| Vendors | Price Range | Products Offered | Reviews | Verdict | Buying Link |
| Purerawz | $30.48 – $111.98 | Semax nasal spray, N-Acetyl Semax peptide, Sublingual tablets | Positive reviews, trusted source | Trusted, an established vendor with high-quality Semax and excellent customer service. | Buy Semax from Purerawz |
| Behemothlabz | $158.48 – $280.98 | Semax nasal spray, N-Acetyl Amidate nasal spray | Generally positive | Highly reliable, offering top-tier customer service, and clear lab-tested products. | Buy Semax from Behemothlabz |
| Rcd. bio | $73.98 | Semax nasal spray, N-Acetyl Amidate nasal spray | Generally positive, established | Solid reputation, known for quality and transparency with third-party testing. | Buy Semax from Rcd. bio |
| Science. bio | $39.99 – $89.99 | N-Acetyl-SemaxAmidate Acetate – Aliquot | Mixed reviews, Good vendor | Excellent and well-established, with decent products. | Buy Semax from Science. bio |
| Iron mountain labz | $90.00 | Semax nasal spray | Mixed reviews | Newer with mixed reviews; prices are reasonable. | Buy Semax from Iron Mountain Labz |
All these vendors provide you with the first and third-party tested Semax at affordable prices. Their website is user-friendly and allows you to place your order effortlessly. Moreover, a majority of their customers rated them highly due to their exceptional products and services.
Semax Vs Selank: What’s The Difference?
While both were originally developed by the Institute of Molecular Genetics in Russia, there are at least two key differences between Semax and Selank.
- Both are derived from different sources. While Semax is a small segment of ACTH, Selank is related to the immune system. It’s derived from the endogenous tetrapeptide Tuftsin, an immune system peptide that protects your immune system against viruses, bacteria, and tumors.
- Both have starkly different uses. Semax is used in the prevention and treatment of circulatory disorders. Selank, on the contrary, was initially intended to be a neuropsychotropic and is used to treat opioid withdrawal, among other conditions.
When used together, Selank and Semax might improve the brain’s cognitive function, accelerate nerve regeneration, and improve both your immune and vascular systems
FAQs
1. Where did Semax Come From?
Semax was developed in Russia in the 1980s. It was initially used to prevent and treat circulatory disorders, such as strokes, heart attacks, and high blood pressure. The drug proved to be so effective that its researchers won the Prize of the Government of the Russian Federation in 2001.
2. Is Semax Nasal Spray Good?
Yes, Semax nasal spray is considered good as a nootropic peptide. The nasal spray offers quick cognitive effects.
3. How does Semax Improve Cognitive Function?
By boosting the activity of neurotransmitters such as dopamine and serotonin, Semax helps regulate cognitive function including mood, focus, and motivation.
4. What is Semax?
Semax is a synthetic heptapeptide with nootropic properties. It binds to the melanocortin receptors to activate dopamine and serotonin, enabling us to cope with anxiety and mental fatigue.
5. Is Semax Neuroprotective?
Yes, Semax is known to have neuroprotective properties to help protect brain cells from damage in case of ischemia and oxidative stress.
On the Whole
Semax offers various sought-after benefits. This neuropeptide helps increase your motivation, enhance cognition functions, and improve mental clarity. You can also count on Semax to improve blood circulation throughout your body, thereby providing various other benefits.
Semax has also been shown to treat depression. It stimulates the release of hormones (dopamine and serotonin) which have known antidepressant properties. Any of you who is feeling glum has thus an extra incentive to use this drug.
Remember, Semax is an unscheduled drug. This means its risk profile isn’t fully known. If you have any pre-existing medical conditions or are already taking any supplements, we suggest that you consult with your doctor before you start taking Semax nootropic.
References
- BDNF gene: MedlinePlus Genetics. (n.d.). Medlineplus.gov. https://medlineplus.gov/genetics/gene/bdnf/
- Licinio, J., & Wong, M-L. (2002). Brain-derived neurotrophic factor (BDNF) in stress and affective disorders. Molecular Psychiatry, 7(6), 519–519. https://doi.org/10.1038/sj.mp.4001211
- Kost, N. V., Sokolov, O. Yu., Gabaeva, M. V., Grivennikov, I. A., Andreeva, L. A., Myasoedov, N. F., & Zozulya, A. A. (2001). Russian Journal of Bioorganic Chemistry, 27(3), 156–159. https://doi.org/10.1023/a:1011373002885
- Rice, M. E. (2019). Closing in on what motivates motivation. Nature. https://doi.org/10.1038/d41586-019-01589-6
- Poor health, and lifestyle factors are linked to memory complaints, even among younger adults. (n.d.). UCLA. https://newsroom.ucla.edu/releases/poor-health-lifestyle-factors-linked-to-memory-complaints-even-among-younger-adults
- Asmarin, I. P., Nezavibat’ko, V. N., Miasoedov, N. F., Kamenskiĭ, A. A., Grivennikov, I. A., Ponomareva-Stepnaia, M. A., Andreeva, L. A., Kaplan, A. I., Koshelev, V. B., & Riasina, T. V. (1997). A nootropic adrenocorticotropin analog 4-10-semax (l5 years experience in its design and study). Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova, 47(2), 420–430. https://pubmed.ncbi.nlm.nih.gov/9173745/
- Filippenkov, I. B., Stavchansky, V. V., Denisova, A. E., Yuzhakov, V. V., L.E. Sevankaeva, Olga Yu. Sudarkina, Дмитриева, В. Г., Gubsky, L. V., Myasoedov, N. F., Limborska, S. A., & Dergunova, L. V. (2020). Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia–Reperfusion in Rats. Genes, 11(6), 681–681. https://doi.org/10.3390/genes11060681
