Have you heard about the healing powers of TB-500? Meet Purerawz’s TB-500 Sublingual tablet. This is based on Thymosin Beta-4 and is intended to help your body heal more quickly and effectively. TB-500 mimics this protein that is found naturally in your body to enhance healing through the reduction of inflammation, stimulation of cell development, and acceleration of repair. Unique in its sublingual form, this tablet is your gateway to enhanced tissue repair and regeneration, acting as a master key for swift healing. Elevate your recovery and minimize downtime with this compound tailored to support your healing journey.
Now, let’s explore what makes PureRawz Sublingual TB-500 Tablets stand out! These unique tablets offer a special way of delivering the benefits of Thymosin Beta-4. By going sublingual (under the tongue), they make sure your body absorbs the goodness efficiently. This method allows for quick absorption and avoids the liver’s first-pass metabolism, ensuring you get more of the active substance in your system. Get ready to discover the special qualities that make PureRawz Sublingual TB-500 Tablets a standout choice for healing and recovery.
Introduction
But before we dive into the sublingual tablet itself, let’s first explore what TB-500 is all about. TB-500 is a synthetic form of Thymosin beta-4. This protein is encoded by the TMSB4X gene in humans. Its recommended international name is ‘timbetasin’ according to the World Health Organization. The protein is made up of 43 amino acids and has a molecular weight of 4921 g/mol. Thymosin beta-4 is found in various tissues and can be a significant part of cellular composition. Its concentration within cells can be relatively high, reaching up to 0.5 mM. After Thymosin α1, Thymosin beta-4 was the second biologically active peptide from Thymosin Fraction 5 to be fully sequenced and synthesized. [R][R]
Thymosin Beta 4 is essential for promoting angiogenesis, or the growth of new blood vessels, in the tissues of the skin. Despite this, TB-500 is still being investigated for its possible effects on stem cell maturation, anti-inflammatory activity, cell migration, tissue repair, development of new blood vessels, and cell survival. [R]
It’s claimed that a racehorse can benefit from several medical benefits from this synthetic peptide, which was initially developed for veterinary purposes. A test method to identify the usage of this chemical in horses was developed as a result of these assertions. [R] This also gave way to human clinical studies.
Product Information:
The effectiveness of the product relies on its form. Sublingual tablets, unlike regular pills you swallow, have benefits like fast absorption. When you use a medicine under your tongue, it gets into your bloodstream faster. The high permeability of the tissues under the tongue allows the medication to quickly enter the bloodstream, bypassing the digestive system. [R] Basically, this method is efficient because the tissues under the tongue have a rich blood supply and a thin layer, enabling the medication to be absorbed directly into the bloodstream, avoiding the slower process of digestion.
Purerawz presents its TB-500 in an exclusive Sublingual Tablet form, distinguishing itself as a reputable and innovative option in the market. The commitment to quality is evident with a 99% purity level, thoroughly verified by both first and third-party laboratories. This guarantees users a top-tier product, supported by stringent testing protocols. Opt for Purerawz for a distinct and trustworthy experience, where the standard is nothing short of excellence.
How does TB-500 Work?
Image source: Pubchem
TB-500 functions by interacting with cell receptors and proteins to affect cell signaling. It sets off a chain of events that regulate the functions of cells. Actin is a protein that shapes cell structure, and TB-500 binds to it similarly to its natural counterpart Thymosin Beta-4. To preserve cell mobility and shape, it aids in actin regulation. [R]
Cell migration, or the movement of cells to particular locations throughout the body, is facilitated by TB-500 and is essential for tissue regeneration and wound healing. It promotes angiogenesis, which creates new blood vessels to carry nutrients and oxygen and aids in healing. [R]
Due to its anti-inflammatory qualities, TB-500 reduces the amount of inflammation that forms in damaged tissues. It helps create a more favorable atmosphere for healing. The network of proteins that supports cell structure, the extracellular matrix, is likewise maintained and repaired by TB-500. [R]
TB-500 – Benefits:
To make things easier for you, we’ve compiled information from recent research that indicates TB-500 may have health benefits in addition to its widely reported off-label claims, which have generated a lot of discussion in a variety of places. These results, along with their effects on healing, should open our eyes to fascinating new possibilities when it comes to using TB-500.
1. Rheumatoid Arthritis Management
Rheumatoid arthritis (RA) involves abnormal tissue growth (pannus) in joints due to persistent inflammation. The joint lining, called synovium, experiences increased immune cell infiltration, leading to overgrowth of certain cell types. This creates a low-oxygen (hypoxic) environment, prompting the expression of inflammation-related genes, including vascular endothelial growth factor. Thymosin β4 (Tβ4), a small protein, plays essential roles in cell activities like controlling actin, cell movement, inflammation, and repair. Recent studies suggest Tβ4 might be involved in RA. Tβ4 levels are notably higher in the joint fluid and blood of RA patients. However, whether Tβ4 encourages or hinders RA immune responses is still uncertain. This study explores the logical and clinical reasons supporting Tβ4 as a potential target for RA treatment. [R]
2. Improve Heart Problems
In a study with animals that had a heart attack, treatment with TB-4 improved the function of the left ventricle and decreased cardiac remodeling. Treated animals showed increased levels of CD73 activity and chitinase 3-like-1. Increased CD73 activity could lead to higher levels of adenosine, potentially contributing to improved blood flow and reduced inflammation in the heart. While elevated CHI3L1 levels may indicate an ongoing repair or remodeling process in response to myocardial infarction. Thus implying that TB-4 has a potential link to heart-protective effects. [R]
In a phase 2 clinical trial, TB-4 was found to decrease scar volume after a heart attack in patients with acute myocardial infarction or when blood flow to a part of the heart muscle is blocked, leading to damage or death of the heart tissue. TB-4 was confirmed to protect and repair the heart. [R]
Another study highlighted TB-4’s various roles in safeguarding, repairing, and regenerating the mammalian heart. It promotes cell survival, adjusts the inflammatory environment in the damaged heart, and reactivates the dormant epicardium, which is the outermost layer that covers the heart’s surface. [R]
3. Liver Injury Mitigation
The study looked at how thymosin β4 (TB4) affects liver damage and scarring caused by carbon tetrachloride (CCl4) in rodents. Results showed that CCl4 led to liver injury in mice and rats, with increased liver enzymes, oxidative stress, and inflammation. It also causes collagen buildup and structural changes in the liver tissues. However, when treated with TB4, these harmful effects were significantly reduced. TB4 appeared to protect the liver from CCl4-induced damage by reducing oxidative stress and inflammation, suggesting a potential preventive role in acute liver injury and fibrosis. [R]
4. Enhancing Growth and Development
A study found that Thymosin Beta 4 (TB-4) increased in the blood of people during exercise, regardless of insulin resistance or the type of exercise. However, when mice with diet-induced obesity were treated with TB-4, it didn’t improve metabolic issues or boost muscle regeneration. Interestingly, TB-4 did increase the growth of bone-forming cells (osteoblasts) and the growth of nerve fibers (neurite outgrowth), which led to its classification as a prohibited growth factor by the World Anti-Doping Agency (WADA). [R]
Additionally, in a laboratory study, it was discovered that Thymosin Beta 4 is produced more at the site of muscle injury, promoting the movement of myoblasts and aiding in the regeneration of skeletal muscles. [R]
5. Mitigating Chronic Muscle Weakness
Duchenne Muscular Dystrophy (DMD) is a condition that weakens and wastes muscles, especially in the pelvic area. In a study using mice with DMD, researchers looked at how continuous TB-4 treatment affected muscles. Results showed that mice treated with TB-4 had a notable increase in the regeneration of muscle fibers compared to untreated mice. This suggests that ongoing TB-4 treatment might have a potential role in treating muscle issues in Duchenne muscular dystrophy. [R]
6. Eye and Skin Wound Repair Properties
At the 7th International Congress of Allergy and Immunology in New York, researchers from the United States and Europe presented their research on Thymosin Beta 4 (TB4), an investigational medication for wound healing. The National Institutes of Health (NIH) and RegeneRx Biopharmaceuticals collaborated to produce TB4, which has demonstrated encouraging results in lowering inflammation and speeding up eye wound healing. [R]
Production of purified TB4 using Escherichia coli bacteria has also been utilized in the study. They examined the protein’s capacity to promote wound healing and cell proliferation when a portion of it was removed. The findings demonstrated that this TB4 variant can promote immune cell proliferation and improve wound healing in mice. This is the first time that human TB4 produced in a laboratory has been demonstrated to aid in wound healing. [R]
7. Diabetes Management
To check how effective thymosin beta 4 (Tβ(4)) is against high blood sugar and insulin issues in mice with type 2 diabetes (T2DM), a study conducted tests on KK mice. These mice are known for being prone to obesity and diabetes and show traits linked to metabolic syndrome, such as high blood sugar, insulin resistance, and obesity. Tβ(4) reduced insulin resistance and decreased glucose intolerance. Tβ(4) is a possible substitute insulin sensitizer for the management of type 2 diabetes. [R]
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8. Brain Injury Improvement
There are currently no viable pharmaceutical treatments for traumatic brain injury (TBI), despite it being a major global health concern. The failure of recent clinical studies for traumatic brain injury highlights the critical need for efficient treatments. Natural brain repair mechanisms including angiogenesis, neurogenesis, and synaptogenesis occur after traumatic brain injury (TBI), which aid in the body’s healing process. These procedures are constrained, though, and strengthening them might enhance functional recovery. Clinical trials have demonstrated the potential of thymosin beta4 (Tβ4), a molecule possessing many features like anti-apoptosis, anti-inflammation, and promotion of tissue repair, including wound healing, for ailments such as corneal, cutaneous, and cardiac injuries. According to this article, Tβ4 may help the brain’s innate healing processes and be a neuroprotective and neurorestorative option for treating traumatic brain injury. [R]
9. Eye Problem Management
In a study, 72 people with moderate to severe dry eye were treated with either a 0.1% thymosin beta-4 (TB4) optic drop solution or a placebo for 28 days. The goal was to assess the effects of TB4 as an eye drop. Corneal staining, a measure of damage linked to dry eye, was used. The results showed no harmful effects, and there was a significant improvement in corneal staining, particularly in the upper and central parts of the eye. [R]
In a similar case, nine patients with severe dry eye participated in a 56-day phase-2 clinical trial and were treated for 28 days with either thymosin beta-4 ophthalmic solution or a placebo, with a 28-day follow-up. On day 56, the six patients receiving thymosin beta-4 showed a reduction in corneal fluorescein staining of 59.1%, while there was a reduction in ocular pain of 35.1%. [R]
In another study conducted by the same researchers, thymosin beta-4 (TB4) was used as an eye drop (ophthalmic solution) on nine patients with chronic nonhealing neurotrophic corneal ulcers. Among the six patients who had geographic corneal defects (distinct areas of damage), significant healing was observed without the development of new blood vessels (neovascularization). This suggests that the application of TB4 as an ophthalmic solution may contribute to the healing of chronic corneal ulcers, particularly in cases with specific corneal defects, and without the unwanted formation of new blood vessels. [R]
Research on TB-500 does not end here. Some of the label claims that users have noted include:
10. Tennis Elbow Recovery
Tennis elbow, medically known as lateral epicondylitis, is a condition characterized by pain and inflammation on the outer part of the elbow. Despite its name, tennis elbow is not exclusive to tennis players; it can affect anyone who repeatedly uses their forearm muscles and tendons, leading to strain and overuse. [R] The user claimed that it sped up recovery in an injection manner of administration. [R]
11. Arm Wrestling Recovery Assistance
A user reported to benefit of speeding up injury healing and recovery using TB-500 alongside BPC-157. [R]
Side Effects:
As of this writing, scientists cannot agree upon what negative effects, if any, could result from giving TB-500. This is mostly because there hasn’t been much clinical study done on the negative effects of thymosin beta-4 or TB-500. The publication published in 2010, of one of the few studies on the subject, which involved ten healthy participants. According to the study, the adverse effects of synthetic thymosin beta-4 were low to moderate in severity and uncommon. Only a small number of headaches, dizziness, and hot sensations were thought to be possibly related to thymosin beta-4. No dose-limiting toxicities or significant side effects were noted. [R]
According to another study, intravenous administration of synthetic TB4 at a dose range of 42–1260 mg, either as a single dose or in several daily doses, was well-tolerated for 14 days. No clinically significant results were seen in vital signs, ECG assessments, or physical examinations despite these large dosages. [R]
Furthermore, 54 healthy volunteers took part in a more recent trial, which found that after 10 days of intravenous thymosin beta-4 injection, there were no significant negative effects. In a single-dose study, the cohorts were given escalating doses ranging from 0.05 to 25.0 mcg/kg. Afterward, 30 individuals were randomly assigned to a multiple-dose trial, where they were given 0.5, 2.0, and 5.0 μg/kg daily for 10 days, followed by a 28-day follow-up. In both the treatment and control groups, there were only mild to severe adverse effects that were equal in frequency and severity. Additionally, researchers should be aware that injecting TB-500 can cause local side effects. These could include redness, hemorrhage, swelling, and pain at the injection site. [R]
Is TB-500 Legal?
The use of TB-500 in humans is not authorized. The peptide is a research substance that should only be used in lab settings. Purchasing and owning it is only permitted for researchers and certified lab professionals who want to use it in in vitro experiments.
The peptide should not be obtained or utilized for personal use because most thymosin beta-4 and TB-500 research is now in the preclinical stage and there is a dearth of clinical research.
As previously stated, the peptide is now prohibited by WADA and is not allowed in live horse racing. WADA lists TB-500 in class S2, which also includes growth factors and growth factor modulators, as a prohibited substance. Athletes are advised to abstain from the peptide at all times, including during training, competition, and the off-season. [R]
Suggested Dose:
It’s important to note that there aren’t any precise dosage recommendations for research purposes at this time because there isn’t any published study on TB-500.
The majority of the research that is currently available uses animal models or test participants, therefore extrapolating the results to people is not possible.
Injectable thymosin beta-4 has been the subject of a few human trials; these studies describe variable doses of TB-500, with a maximum 14-day length of administration. Clinical trials using TB-500 peptide treatment regimens longer than two weeks have not been conducted. [R] [R]
As an alternative, thymosin beta-4 has also been successfully used topically for more than three months in clinical trials at 0.03% dosages. Superior safety and tolerability have also been demonstrated in topical usage. [R]
Purerawz has exhibited its dedication to continuous innovation through the introduction of TB-500 Sublingual Tablet form at a dosage of 500mcg/15ct/7.5mg and 500mcg/30ct/15mg.
FAQ
Is TB-500 a steroid?
No, TB-500 is not a steroid. It is a synthetic version of Thymosin Beta-4, a naturally occurring protein peptide. TB-500 does not share structural or mechanistic similarities with anabolic-androgenic steroids.
How long is TB-500 detectable in urine?
No study has been done yet for the number of days it can be detected in urine since it will depend on the dosage. The Hong Kong Jockey Club Racing Laboratory reported developing a test specifically designed to detect same-day administration of N-acetylated LKKTETQ from TB-500. The researchers were able to detect a metabolite of N-acetylated LKKTETQ, unique to the synthetic peptide, in plasma for 11.3 hours but only for 9.7 hours in urine samples. [R]
Is TB-500 banned by WADA?
Yes, thymosin Beta-4 (TB-4) and its synthetic form TB-500 are peptides that have been included in the list of substances prohibited by the World Anti-Doping Agency (WADA) for sports competitions. The use of TB-500 is generally considered a form of doping in sports.
Where to Buy TB-500 Online?
Purerawz has been one of the market’s hidden heroes since 2014, constantly releasing high-quality products that contribute to people’s overall health and happiness. They’ve been working with TB-500 for a long time, so they’re a safe bet. Are you still unsure? Customer testimonials can be found on the Purerawz website
This trustworthy online shop is the best place to buy anything. They have a round-the-clock chat service and cite research to back up their claims. If you haven’t tried them yet, do so immediately. Obtain the top-tier TB-500 immediately!
Conclusion:
Purerawz has introduced a sublingual pill with a 500mcg/15ct/7.5mg and 500mcg/30ct/15mg dosage so that individuals can discover what their own particular needs are.
The Purerawz TB-500 Sublingual Tablet shows promise as a substance for improved tissue regeneration and repair. TB-500 interacts with proteins and cell receptors through molecular structures that mirror those of natural proteins. This influences cell signaling, which in turn regulates a variety of cellular processes. By taking advantage of the high permeability of the tissues under the tongue, the sublingual tablet form is intended for quick absorption.
The product’s purported 99% purity has been confirmed by independent and first-party laboratories. Research suggests that TB-500 may be beneficial for conditions other than traditional wound healing, including rheumatoid arthritis, heart issues, liver damage, growth and development, chronic muscle weakness, diabetes management, brain injury improvement, and eye problems.
Although some users have claimed that the product helps with arm wrestling injury healing and tennis elbow recovery, it’s important to be aware of the scant scientific agreement regarding possible adverse effects. More thorough clinical study is required, even though existing studies indicate that adverse effects are rare and of low to moderate severity.
According to the legalities, TB-500 is a research chemical and is not permitted for use on humans. WADA lists it as a restricted substance, along with growth factors, and forbids its usage in sports. Because there is a minimal of published research, the recommended dosage is still unknown.
