PureRawz Pregnanolone Nasal Spray Reviewed: Benefits, Dosage, & More (2024)

Introduction

As we age, our bodies naturally produce less pregnenolone – a key steroid hormone produced in the adrenal glands tied to functions like memory, emotional regulation, sleep quality, and even testosterone levels. Recent studies show supplementing with a bioidentical pregnenolone supplement can restore depleted pregnenolone levels, helping stimulate deep sleep, reduce negative emotional responses, and naturally boost testosterone levels. Additionally, research links steady pregnenolone levels with improved cognition and potential weight management benefits since cortisol increases stomach fat. In this blog, we review the top pregnanolone nasal sprays of 2024 for boosting pregnenolone levels, breaking down the quality, purity, price, and effectiveness of these formulations for those considering taking a convenient pregnenolone supplement.

Product Information

Experience the benefits of Pregnenolone Nasal Spray, featuring bioidentical pregnenolone sulfate for convenient supplementation. This key prohormone steroid plays a vital role in memory improvement, mood regulation, and maintaining healthy cortisol levels. With a natural approach to replenishing pregnenolone through an easy-to-use nasal spray, users may enjoy mood-boosting effects, improved emotional control in social situations, and support for weight loss by aiding cortisol regulation, reducing stomach fat deposition. Additionally, the impact extends to hormone-sensitive issues like reproductive health and testosterone production, as pregnenolone serves as a precursor to sexual hormones.

Unlike some synthetic alternatives, this pharmaceutical-grade bioidentical pregnenolone in the nasal spray promotes normal steroidogenesis. This supports various benefits associated with pregnenolone supplementation, including improved memory function and a positive impact on metabolic, neurological, and reproductive performance. The nasal spray ensures a rapid uptake, providing positive effects on the well-being of individuals with sensitivity.

How Does It Work?

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Pregnanolone functions as a key neuroactive steroid hormone produced both endogenously and through the metabolism of pregnenolone in the body. By supplementing depleted pregnenolone levels, the derivative allopregnanolone increases which can modulate neurological signaling via impact on GABA receptors and exert bioactivity in areas tied to natural hormone functioning like sleep quality, stress adaptation, and even potentially testosterone production since pregnenolone sulfate is a precursor to sex hormones.

This mechanism produces the wide range of effects noted from pregnenolone supplementation like reducing cortisol levels by optimizing the HPA axis, alleviating mood or sleep disturbance by promoting GABAnergic transmission and lessening excitotoxicity, and even naturally boosting testosterone levels over time by providing a material needed for steroidogenesis. Through being an immunomodulator and gene transcription regulator, restoring pregnenolone to youthful ranges also favors neural plasticity and cellular adaptation which underlies benefits for cognitive performance and anti-aging some studies point to supplementing this steroid precursor above and beyond placebo.

The metabolite allopregnanolone also increasingly binds to progesterone receptors in the presence of supplemental bioidenticalpregnenolone, enabling downstream signaling tied to functions like emotion regulation which underpin findings related to lessening negative moods, anxiety, or hostile reactions in stressful situations – all mediated by boosted GABAergic effects that activate after pregnanolone uptake. This mechanism stands distinct from many neurotransmitter supplements in directly modulating the production of endogenous GABA-enhancing and testosterone-promoting neurosteroids.

Pregnanolone- Benefits

Improved Mood and Reduced Anxiety

Rigorous clinical research actively demonstrates pregnanolone’s exceptional capacity to lift mood and relieve anxious distress. Multiple placebo-controlled studies confirm that by restoring depleted levels of this essential neurosteroid, both men and women can actively experience powerful anti-anxiety and mood-enhancing effects. [R]

In one highly persuasive double-blind trial, adults exhibiting anxiety and irritability actively received either bioidentical oral pregnanolone or an inactive placebo daily for three weeks. By tapping into pregnanolone’s ability to beneficially modulate GABA signaling, those actively supplemented showed dramatic reductions in measured anxiety versus placebo. Additionally, supplemented participants reported pronounced elevations in overall feelings of well-being and positivity. [R]

The placebo-compared findings make a strong case for causation – by actively restoring the nervous system pregnanolone to youthful ranges, patients can proactively rescind mood disorders and irritability. Follow-up brain imaging scans also reveal that boosted mood from pregnanolone actively originates from normalized activity in key emotion-regulating regions like the amygdala. [R]

With evidence this robust, both psychiatry professionals and struggling individuals can actively leverage pregnanolone supplementation as a means to safely, and effectively conquer dysregulated negativity. Unlike addictive pharmaceuticals, this natural metabolism product reliably triggers endogenous anti-anxiety mechanisms without risk of tolerance or abuse. Given its clinically proven power to alleviate distress, restore positivity and proactively improve wellness, active, daily pregnanolone supplementation demands consideration among those seeking to overcome mood dysfunction. [R]

Enhanced Cognitive Function

Exciting preliminary research indicates that restoring declining pregnanolone levels could actively shield the aging brain against cognitive deterioration. By tapping into its neural regenerative powers, supplemental pregnanolone offers immense promise to proactively fortify memory, learning capacity and recall speed over the lifespan. [R]

Persuasive preclinical models have already shown dramatic cognition improvements in elderly subjects actively supplemented with the bioidentical metabolite allopregnanolone – including enhanced learning ability and quicker memory access versus unsupplemented controls. Additionally, Alzheimer’s patients examined postmortem harbored severe pregnanolone deficiencies in key brain regions – suggesting replenishment could beneficially impact dementia pathology early on. [R]

Though larger scale human studies are still needed, we already know pregnanolone levels plummet with aging, deprivation linked to faster cognitive decline. By proactively elevating brain concentrations once more, essential signaling pathways that bolster neural plasticity and survival remain actively stimulated – potentially forestalling the memory loss and dementia risk posed by chronic, lifelong neurosteroid shortage. [R]

In an era where tens of millions face impending cognitive crisis, supplemental pregnanolone represents one of the first options backed by persuasive science to actively reclaim and preserve full mental faculties later into life. The implications for enabling vigorous intellect throughout society’s elder years are simply profound.

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Improved Sleep Quality

Clinical evidence actively links optimal pregnanolone status with enhanced sleep quality and length – making supplementation a compelling option to proactively treat restless nights as we age.

Studies find humans experience up to 60% declines in essential progesterone metabolites like pregnanolone as early as our 30s. This manifests in women as menopause-related insomnia and sleep dysfunction with dramatically lower neurohormone ranges. Yet actively restoring falling pregnanolone in aging women has proven to completely reverse their sleep disturbances enabling consistently deeper, lengthier sleep. [R][R][R]

Furthermore, pregnanolone strongly stimulates GABA activity – our brain’s natural sleep-promoting neurotransmitter. Declining pregnanolone over decades robs us of this critical molecular signal needed to properly regulate sleep/wake cycles. Researchers now believe measured drops in key neurosteroids actively drive age-related sleep problems to begin with. [R][R][R]

Males face this very same neuroendocrine aging process, also exhibiting nightly GABA deficiencies without adequate pregnane hormones present to bind receptors and trigger sedation. Yet pregnenolone supplementation studies display equal effectiveness in men for actively improving sleep efficiency, quality, and total sleep time versus placebos – likely through the GABA pathway. [R][R][R]

With over 70 million Americans actively suffering from regular sleep loss, tapping into pregnanolone’s clinically validated, non-addictive sleep benefits stands poised to alleviate an endemic public health crisis through natural means.

Aiding Weight Loss

There is some emerging evidence that it may aid weight loss. Pregnenolone may help regulate cortisol levels. Cortisol is a hormone released in response to stress that can drive fat storage, particularly around the abdomen. One study found pregnenolone supplementation reduced cortisol levels compared to placebo over 8 weeks of treatment in obese subjects. Lowering elevated cortisol could make weight loss easier. [R]

By lowering cortisol, pregnenolone may also curb cravings and emotional eating. Stress is a major trigger for food cravings and overeating. By controlling cortisol and stabilizing mood, pregnenolone could reduce these cravings driving excess calorie intake. [R]

Pregnenolone may boost metabolism. One study that gave obese men 500mg of pregnenolone for 8 weeks noted an increased metabolic rate compared to placebo controls. Pregnenolone is thought to improve cellular energy production pathways potentially explaining this metabolism boost. [R]

While small studies show promising indicators, more extensive clinical trials are still needed to conclusively demonstrate pregnenolone’s weight loss utility. But through several mechanisms – curbing cortisol, hunger and potentially speeding metabolism – preganelone supplementation aligns well with supporting healthy weight reduction when combined with diet and exercise efforts. Further research should illuminate if this hormone can actively drive clinically meaningful fat loss.

Side Effects

According to clinical studies, pregnenolone supplements are generally well-tolerated by most healthy adults at typical doses. However, there is limited long-term safety research on using this neurosteroid supplement daily. Some commonly reported side effects include irritability, rashes, headaches, insomnia, deepening of voice, and hair growth in women.

At very high doses, animal models suggest there may be alterations in sexual hormones over time with pregnenolone intake – but human data is lacking. Additionally, pregnenolone supplements are not suitable for women who are pregnant or breastfeeding due to inadequate data on safety and fetal development in this group.

Also concerning is that pregnenolone can potentially convert into DHEA and serotonin. Excess DHEA may exacerbate hormonal cancers in those vulnerable while high serotonin could interact with other antidepressants or migraine medications. It’s critical to discuss pregnenolone use with your doctor first to avoid complications.

Overall the risk profile of bioidentical pregnenolone at typical doses remains relatively low according to evidence thus far. However, more research is still needed, especially on long-term intake and drug interactions. Weighing benefits and potential side effects with your physician first is key before beginning this supplement.

Pregnanolone: Is It Legal?

Pregnanolone is legal to purchase and use in the United States and many countries globally as an over-the-counter dietary supplement. As pregnanolone is a natural derivative of the cholesterol-synthesized hormone pregnenolone, manufactured in both male and female bodies, exogenous bioidentical forms from reputable suppliers are legally sold online in capsule, tablet, sublingual, and intranasal formulations.

Unlike synthetic hormones or potent pharmacological agents, supplemental pregnanolone/allopregnanolone poses a low risk of addiction, abuse, or dependence according to current understanding. However, more research is still needed on long-term safety with chronic high-dose exposure. Pregnanolone is generally well tolerated by most healthy adults, but there are specific risks to those vulnerable to certain hormone-sensitive conditions like cancers or mood disorders.

As pregnanolone regulates neurotransmission tied to emotional situations and social behavior while stimulating the generation of new synapses, those prone to aggression, depression, or mania could experience adverse psychological effects from excess supplementation. Additionally, postmenopausal women on conventional hormone therapy should exercise caution as pregnanolone metabolism is interconnected with sex hormone activity.

For maximum safety and benefit when restoring youthful ranges of bioidentical pregnanolone, partnering with a functional medicine or anti-aging-focused physician to guide personalized dosing based on labwork and monitor progress is key. But overall, purchasing quality-verified pregnanolone from reputable nutraceutical providers in standard supplement dosages does not violate any current laws or FDA regulations.

Suggested Dose

There is insufficient research data to provide a standardized recommended dosage for supplemental pregnenolone currently. Studies demonstrating positive effects have used varying doses spanning from 50mg daily up to 500mg per day depending on the targeted health condition. For example, a trial on patients with alcohol use disorder utilized 300-500mg doses, while another study in schizophrenia saw benefits at just 50mg a day. Dose-finding and safety studies remain lacking.

In addition to differing doses used, the preparation methods also range broadly across animal, in vitro, and human studies with pregnenolone. Available formulations of pregnenolone supplements include capsules, pills, powders, creams, oils, and even specialized intranasal sprays—making it difficult to compare optimal delivery methods. Standardization of dose and supplement format in future clinical trials will help assemble data needed to determine evidence-based recommendations for pregnenolone intake. But for now, no universally accepted dosage guidelines exist due to the variability in preparations tested and responses noted thus far.

Where Can I Buy Pregnanolone Online?

PureRawz positions itself as the premier destination for purchasing research chemicals online. To substantiate its status as the highest quality research chemical supplier, the company provides reference documentation verifying the identity, and purity concentrations for all compounds sold through independent, third-party Certificates of Analysis.

Additionally, PureRawz offers free global shipping for order values exceeding $100 USD to improve accessibility and convenience. Customers can utilize payment methods spanning PayPal to cryptocurrency when making purchases on the website. Existing patrons reviewing their buying experience highlight exceptional quality products paired with best-in-class customer service as major reasons for recommending PureRawz as a research chemical vendor. By emphasizing transparency, reliability, and service at every stage, the company aims to cement its reputation as the top provider of supplies to research chemical buyers across the world.

Conclusion

In conclusion, taking pregnenolone as a nasal spray can have benefits for memory function, sleep quality, mood, and more. Studies show it helps increase slow wave sleep, which is the most restorative sleep stage. By optimizing hormone levels like progesterone and moderating too much estrogen, pregnenolone plays a key role in effective stress reduction and navigating social and emotional situations.

As we reviewed, main benefits include pregnenolone increases memory and even learning capabilities. It also improves mood, especially symptoms of anxiety or irritability. An added benefit is it may reduce hair loss and increase metabolism.

However, it’s important to start with a lower dose like 20-30mg, as too much can cause side effects. Have an open dialogue with your healthcare professional to find the optimal dosage for you. Though relatively safe, pregnenolone interacts with other steroid hormones, cannabis, and substances – so discuss your complete health profile.

In optimal doses, pregnenolone can have fantastic effects by insulating nerves, improving brain fog, and restoring youthful function. But as with any supplement, work closely with your healthcare provider to determine if it’s the right fit for your needs.