Pramiracetam Review A-Z: Dosage, Benefits, & More (2022)

Pramiracetam is one of the most popular nootropics right now. Derived from piracetam, this compound is 30-times more powerful than its parent compound.

Users of this nootropic vouch for its potency. They claim that a 2-month course rivals the best nootropics, in terms of brain power boosted and cognition enhanced.

But is there any truth to these bold claims, or are they just hype? And, if Pramiracetam is as potent as animal studies claim it is, what does that say about its side effects?

In this Pramiracetam review, we’ll explore the science behind this nootropic, to help you decide whether you should start using this supplement or not. So, take a seat, relax, and continue reading.

What is Pramiracetam?

Pramiracetam Powder

First things first, what is Pramiracetam? At the cost of sounding technical, it’s a synthetic racetam derivative, just like Oxiracetam. It was initially developed in the late 1970s by the Parke-Davis pharmaceutical company and was distributed under the Primastar brand name.

Pramiracetam was originally synthesized to help patients suffering with brain injury, neurodegenerative disorders, and various central nervous system disorders. Later on, in April 1993, it was marketed as a treatment for age-associated memory loss. [R]

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What makes Pramiracetam unique is that it’s 30-times more powerful than piracetam, the nootropic from which it is derived. Piracetam has been proven to boost brain function and enhance cognition. It could also reduce negative cognitive symptoms.

Pramiracetam has been widely used in some European countries for the past few decades. Recently, its popularity has grown in the US too. People use it to optimize their brain function and improve memory formation, retrieval, and processing. It also boosts focus and concentration.

Overview of Effects & Benefits of Pramiracetam

Before we focus our energies on what the scientific community has to say about Pramiracetam, let’s have a quick overview of its benefits and effects.


  • Improves Memory
  • Enhances Cognition
  • Offers Neuroprotection
  • Increases Mental Clarity
  • Eases Dementia Symptoms

Side Effects

  • Headache
  • Nausea

These side effects can be avoided by sticking to a low dosage.

Pramiracetam is legal in Europe. Doctors prescribe this drug to patients of Alzheimer’s disease and other types of dementia. Various studies have shown that dementia patients experienced improvement symptoms after taking Pramiracetam.

Pramiracetam isn’t illegal in the United States, even though it hasn’t been approved by the US Federal Drug Administration. Nor is it considered a regulatory supplement or has any schedule attached to it. This means that you can legally buy, possess and use Pramiracetam in the US.

Where can I buy Pramiracetam from?

You can buy Pramiracetam powder from Pure Rawz, one of our most trusted supplement vendors. All of Pure Rawz’s supplements come with a 30-day guarantee, publicly available lab reports and a 100% satisfaction guarantee. You can count on them to be safe and effective.

Powder formulation will allow you to take Pramiracetam alone or mix it with a drink. Make sure, though, not to take Pramiracetam with alcohol. Users report that the drug’s potency suffers if you take it with an alcoholic beverage. Water or caffeine (tea/coffee) are much better options.

If you’re in a hurry, you can have Pure Rawz deliver Pramiracetam on the same day. Just make sure that you select USPS Priority Shipping on the checkout page.

How does Pramiracetam work in the brain?

How does Pramiracetam work in the brain

Pramiracetam increases the synthesis and function of acetylcholine in the brain. Acetylcholine is one of the nervous system’s major neurotransmitters. It’s responsible for expanding blood vessels, helping muscles relax, slowing heart rate, and boosting memory.

Aside from that, Pramiracetam increases nitric oxide activity in the brain. Nitric oxide is crucial for our brain health. It allows cerebral blood flow, thereby improving the efficiency of brain cells (neurons) involved in memory function, learning, and visual function. [R]

Pramiracetam may also enhance or restore cell membrane fluidity in the brain. This is good news given that enhanced cell membrane fluidity leads to better cell signaling, resulting in enhanced cognitive function and an overall improved brain health.

Remember that Pramiracetam doesn’t influence dopamine, GABA, serotonin, or norepinephrine levels in the brain. That is something that sets it apart from the best nootropics right now. For this reason, it cannot improve mood and alleviate anxiety issues. [R]

Benefits of Pramiracetam

Pramiracetam benefits

Proven benefits of Pramiracetam include improved memory, increased recovery from brain injuries, and neuroprotection.

This nootropic supplement has also been shown to reduce a person’s cognitive decline and boasts neuroprotective characteristics, too.

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Pramiracetam also increases cerebral blood flow, thereby providing the benefits increase in blood flow to the brain has to offer.

These include improvements in brain plasticity and neuron development, both of which are associated with cognition.

Here are the benefits of Pramiracetam:

  • Improves Memory
  • Offers Neuroprotection
  • Enhances Cognitive Ability
  • Increases Mental Alertness
  • Clears Brain Fog

Before you start taking Pramiracetam capsules or powder, take a moment to read through these benefits. This will help you know whether the effects Pramiracetam offers are the ones you’re expecting.

1) Improves Memory

Almost 10% of US adults over 45 report memory issues. That is a massively worrying statistic. Decline in mental abilities is one of the earliest signs of impending dementia or Alzheimer’s disease, according to the US Centers for Disease Control and Prevention. [R]

That’s where the bad news ends. Research has shown that Pramiracetam could improve the formation of new memories and the retention of existing ones. Animals experienced a ‘significant improvement’ in their reference memory after taking two doses of this drug. [R]

2) Reverses Cognitive Decline

Cognitive decline is a normal part of aging. Health experts tell us that a few mild changes in cognition are nothing to worry about as you age. However, while a slight reduction in one’s memory, mental acuity or judgment is normal, dementia isn’t. [R]

A meta-analysis has found that Pramiracetam can effectively reverse various symptoms of cognitive impairment. The analysis found Pramiracetam to be ‘globally’ efficacious in reversing cognitive impairment symptoms in older adults. [R]

3) Increases Mental Alertness

Mental alertness is a crucial recipe for success. When your brain is foggy, it will make you hesitate a hundred times before reaching a decision. This will make it hard for you to make choices that could take you from where you are to where you want to be in life.

Preliminary evidence shows that Pramiracetam increases nitric oxide synthesis in the hippocampus. This is relevant because hippocampus plays a crucial role in memory-guided decision-making. By increasing nitric oxide in this region, Pramiracetam could make you more alert of the world around you. [R]

4) Offers Neuroprotection

Neuroprotection refers to the preservation of the brain cells’ structure and/or function. It’s a set of mechanisms and strategies that protect your nervous system from damage and injury, especially in people who are already dealing with some sort of brain damage or injury.

Pramiracetam might have what it takes to be classified as a ‘neuroprotector’. In one human case, it successfully reduced the symptoms associated with memory loss. Another study found that Pramiracetam could reverse brain-damage caused by toxins or other nootropic drugs.

5) Improves Learning Ability

Researchers have identified why we lose learning ability as we age. Our brain’s hippocampus region has GABA receptors, which are at their lower-most levels during adolescence (when we have the highest learning ability). As we age, the GABA levels go up, hurting our ability to learn new things. [R]

Pramiracetam improves learning ability by targeting the hippocampus. It does that by boosting nitric oxide levels in that region of the brain. NO is associated with learning ability and memory in humans. By increasing its levels, Pramiracetam boosts our learning ability. [R]

6) Enhances Cognition

According to a double-blind, placebo controlled study, Pramiracetam enhances cognition. The study involved multiple young males. All of them were dealing with cognition problems due to brain trauma. They were finding it hard to memorize new information and recall old memories. [R]

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Researchers divided the participants into two groups. One group took 400 mg of Pramiracetam daily for 18 months. The other got a placebo. After the study’s conclusion, it was found that the Pramiracetam group experienced a significant boost in cognition, recall, and memory.

7) Improves Dementia Symptoms

Dementia is an umbrella term for various neurological disorders that impair the patient’s ability to remember, think or make everyday decisions. Alzheimer’s disease is one of the most famous type of dementia. Around the world, more than 50 million people have dementia as we speak.

Open-label trials have shown that Pramiracetam eases dementia symptoms. In the trials, it brought ‘measurable’ improvements to the patients’ memory and cognition. That is probably why Pramiracetam is one of various prescription medications for the Alzheimer’s disease in Europe.

Pramiracetam Side Effects

Pramiracetam Side Effects

Some users report experiencing headaches after taking Pramiracetam. That is something that is common with all racetams because they boost the activity of acetylcholine in the brain. Choline supplements like Alpha GPC can help you overcome or avoid this side effect.

On the whole, Pramiracetam is pretty non-toxic. Majority of the users tolerate this ‘smart drug’ quite well and experience no severe adverse effects. That is despite the fact that Piracetam, from which Pramiracetam is derived, causes anxiety and agitation.

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That is probably because of how both these racetams work in the brain. Piracetam increases dopamine levels in the brain, causing anxiety, agitation, and nervousness. Pramiracetam, though, has no effect on dopamine or norepinephrine.

However, since it’s 30 times more potent than Pramiracetam, it’s advised that you stick to an optimal dose. The risk of overdose is probably much higher with Pramiracetam then with most other smart drugs. It’s recommended you consult a doctor before using it.

How can I reduce Side Effects?

Although Pramiracetam is non-toxic and easily tolerated by most users, it might cause a few side effects. These include headache, stomach discomfort, constipation and nausea. If you’re experiencing more severe side effects, immediately consult your doctor.

To reduce Pramiracetam’s side effects, it’s suggested that you take this supplement with a meal. Don’t ingest this smart drug on an empty stomach to reduce the risk of nausea. Try to drink plenty of water to avoid or ease dry mouth, a problem few users have experienced using it.

Pramiracetam Dosage

Pramiracetam Dosage

Human studies have shown that it’s safe to take up to 1,200 mg Pramiracetam per day.

It has been shown that this dose is effective in improving memory and enhancing cognition. You could split the total dosage into two or three smaller doses. Try to take the last dose well before bedtime, as this smart drug is capable of causing insomnia.

Make sure not to take more than the recommended dosage.

Pramiracetam is incredibly powerful (reportedly 30 times more potent than Piracetam). There’s a risk of overdose if you exceed your daily dose. Overdose might lead to poisoning or other adverse effects, including heartburn, stomach pains.

How can I take Pramiracetam?

Pramiracetam is available in three forms: powder, capsule, or tablet.

We recommend that you take Pramiracetam powder because then you could mix it into a non-alcoholic beverage and consume it as a drink. This will ensure rapid release of the drug’s ingredients, letting you experience the intended effects much quickly.

Pramiracetam is fat-soluble, which means your bloodstream will absorb it in the form of fatty acids. The smart drug will take less than 30 minutes to reach maximum bioavailability. Its half-life of between 4.5 and 6 hours, meaning it might remain in your system for a day.

Pramiracetam Stacks

Pramiracetam Stacks

Pramiracetam gives you multiple stacking options.

You could combine it with other racetams. Pramiracetam is a powerful potentiator and is capable of increasing the effectiveness of most nootropics.

You could also add a choline supplement to your existing Pramiracetam stack. This will help you avoid headaches, this smart drug’s most-reported side effect.

Since Pramiracetam is highly potent, we recommend that you don’t use it as a part of a stack for the first 2-3 months. Observe how your body reacts to this racetam alone, and then mix it with nootropics.

Here are the best Pramiracetam stacks:

1) Pramiracetam Oxiracetam Stack

Stacking Pramiracetam with another cognitive enhancer like Oxiracetam will give you two benefits. It will increase the effectiveness of effects both these racetams are capable of providing. And you’d be able to enjoy the benefits over a longer-period.

2) Pramiracetam Phenibut Stack

Apart from giving you all the benefits of the Pramiracetam/Oxiracetam stack – enhanced cognition, better memory retention, increased energy – stacking Phenibut with Pramiracetam will also lead to enhanced focus, added motivation and an enhanced sense of well-being.

Frequently Asked Questions

What is Pramiracetam good for?

Doctors in Europe prescribe Pramiracetam to patients of Alzheimer’s disease and other types of dementia. Research has shown that it helps improve memory formation and retention, enhances cognition and improves mental alertness.

Is Pramiracetam a stimulant?

Pramiracetam is not a stimulant because it doesn’t increase the activity of neurotransmitters dopamine and norepinephrine in the brain. That is something that prescription stimulants do, per the National Institute on Drug Abuse. [R]


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In conclusion, Pramiracetam is one of the most powerful racetams right now for cognition and memory improvement, learning power enhancement and brain protection as a whole. Just one course of 2-3 months can boost your mental faculties.

Derived from piracetam, it is also capable of reversing cognitive decline and easing symptoms of dementia. Research has further shown that it boosts high affinity choline uptake to boost brain activity and cognitive function.

If you’re looking for 100% pure Pramiracetam, we recommend you get it through Pure Rawz. They’re one of the most trusted vendors when it comes to nootropics, bodybuilding and health and nutritional supplements.

Lastly, if you have queries about Pramiracetam, nootropics or supplements in general, please write to use using the comments box given below.


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