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Methylene Blue Guide: Benefits, Dosage, & More (2024)

Methylene Blue Guide: Benefits, Dosage

Methylene blue was the world’s first synthetic antimalarial drug. Initially synthesized in 1876, it was used against all types of malaria for decades. Its status as an antimalarial drug did take a hit after the development of chloroquine in the 1930s, but MB refused to fade away.

At the time of writing, methylene blue is FDA-approved to treat methemoglobinemia. This is a condition in which the blood loses its ability to carry oxygen. This supplement has also demonstrated efficacy against low blood pressure associated with concurrent kidney and liver failure.

What’s more, recent research has indicated that methylene blue could still be useful for the purpose it was initially synthesized for. This drug has shown efficacy against types of malaria that have grown resistant to other antimalarial drugs, most of which are life-threatening.

This article will tell you all you need to know about Methylene Blue. We’ll start by discussing what this supplement is and how it works. Then we’ll get to the meaty part – the benefits you could get from taking methylene blue and the dosage at which you can expect to acquire them.

What is Methylene Blue?

What is Methylene Blue?

Methylene blue, chemical name methylthioninium chloride, is a salt. It has various uses in medicines as well as in the lab, where it’s used as a dye to help biologists see under the microscope. MB is also used in aquariums to protect and prevent fish from fungal infections.

Methylene blue was initially synthesized in 1876 by German chemist Heinrich Caro. It was originally meant to be used as an aniline-based dye in the textile industry. However, this drug’s fortunes changed when scientists discovered that it could inactivate microbial species.

This discovery led to methylene blue being administered to humans with malaria. It proved to be so effective at preventing the spread of this disease that it became the world’s first synthetic antimalarial drug, one of at least three firsts enjoyed by this compound.

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Methylene blue was also the first antiseptic dye used therapeutically, and the first synthetic compound used as an antiseptic in clinical therapy. Currently, it is FDA-approved to treat methemoglobinemia, a condition in which the blood loses its ability to carry oxygen.

While it was initially invented for different purposes, nowadays people use Methylene Blue as a nootropic compound and anabolic compound, to boost mood and build muscle faster.

How does Methylene Blue Work?

How does Methylene Blue Work?

Methylene Blue Has Demonstrated at Least Three Working Mechanisms:

This supplement has demonstrated the ability to convert the ferric ion in red blood cells (hemoglobin) to ferrous ions. This effect enables it to treat methemoglobinemia, which is caused due to the presence of ferric iron in the blood (which prevents the blood from carrying oxygen). [R]

Secondly, methylene blue acts as an electron donor to complex I-IV of the mitochondria. This is significant as it enables this supplement to increase adenosine triphosphate (ATP) production. Increased ATP production enhances exercise performance, joint health, and heart function. [R]

Methylene blue can also increase heme synthesis. Heme is a protein that helps bind oxygen in the bloodstream. It also helps protect the cardiovascular system from harmful free radicals, thereby protecting and improving your heart health. [R]

Methylene Blue Benefits

Methylene Blue Benefits

Injecting a low-dose Methylene Blue injection in the vein can provide you with many benefits, including enhanced memory, fewer bouts of depression, and a lower risk of Alzheimer’s disease. Methylene blue infusion can also have anti-aging and cognition-enhancing effects.

Methylene blue treatment can also increase your energy levels and help you exercise for longer periods, elevating your threshold of fatigue. This might make this compound worth a try for athletes and bodybuilders who want to gain a competitive edge over their counterparts.

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All of the above benefits are expected at lower doses (revealed below). Higher doses of this compound can promote oxidative stress in the body, causing more harm than good. With this in mind, let’s have a detailed look at the various benefits of this supplement:

1) Enhances Memory and Learning

Have trouble remembering things? Methylene blue might help.

A clinical trial of 26 adults revealed that treatment with low-dose methylene blue solution (0.5 – 4.0 mg/kg body weight) produced a 7% increase in correct responses during memory retrieval tasks. It also helped improve markers of memory encoding and maintenance. [R]

Animal studies have shown that this compound can enhance long-term contextual memory. This is the type of memory that helps in the conscious recall of a specific event.

2) Boosts Mitochondrial Activity

Methylene Blue can help you push your limits in the gym.

This is because of its ability to increase mitochondrial activity. Mitochondria are organelles (small structures in the cell) in which all of the cell’s energy is stored. Anything that can increase mitochondrial activity could thus increase the available energy for the cell to use. [R]

This means that by stimulating your mitochondria, Methylene Blue will make grueling workouts seem much easier to you. It can also expedite your recovery from the workouts, similar to SARMs.

3) Lowers Mortality during Specific Surgeries

Here’s why Methylene Blue is used in clinical settings:

Research has shown that methylene blue reduces mortality in vasoplegic patients (who have low blood pressure due to vascular resistance) after cardiac surgery. [R]

Another study showed that vasoplegic patients who were given low-dose methylene blue before the surgery had a lower death rate than those who were administered a placebo. [R]

4) Acts as an Antidepressant

Did you know that methylene blue is a monoamine oxidase inhibitor?

Monoamine oxidase is an enzyme that is implicated in depression, with its increased activity in the brain linked to severe bouts of depressive episodes. That is why all the antidepressants you see on the market inhibit this enzyme’s activity to elevate your mood.

Methylene blue does the same, per results obtained from a 3-week clinical trial. It was found that females with severe depressive illness experienced a significant improvement after receiving 15 mg/day of methylene blue for 21 days. [R]

5) Has Anti-Aging Effects

Several preclinical studies show that methylene blue has anti-aging effects

One study reported that this drug extended the lifespan of worms by up to 20%, with two other studies showing it extending the lifespans of fruit flies and mice by up to 15% and 14%, respectively.

Another study showed that methylene blue reduces oxidative stress, which is the major cause of skin aging, including wrinkles, pigmentation, and paler skin. So, not only can methylene blue help you live a longer and healthier life, but it may also keep your skin fresh year after year. [R]

6) Can Reduce Inflammation

Methylene blue has demonstrated anti-inflammatory effects in various studies.

This drug has been found to lower inflammation by suppressing nitric oxide production. Nitric oxide is a signaling molecule that plays a key role in the pathogenesis of inflammation. Methylene blue inhibits NO by suppressing the pathway involved in its production. [R]

Due to its anti-inflammatory effects, methylene blue can also provide pain relief. That is because inflammation causes inflammation by causing the wound to swell up, turn red, and send signals to the brain that there is discomfort in a specific body part. [R]

Methylene Blue Results

One methylene blue user reported that he “gets the best feeling and results” when dosing this drug in the 15 – 20 mg range. He reports feeling dizzy and confused, “possibly due to a surge of serotonin” if the dose exceeds 40 mg.

Another user reports taking this supplement after a workout to get a second wind and “go a lot further”. He claims that the main benefit he has noticed is an “increase in energy”, with no “apparent build-up of tolerance”.

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Finally, a third person claims that dosing methylene blue has resulted in an “excellent boost in creativity”, but cautions that anxiety and shortness of breath may follow if taken at larger doses.

Methylene Blue Dosage

Methylene Blue Dosage

Methylene Blue is the most effective at low doses (0.5 – 4 mg/kg).

High doses of this drug should be avoided at all costs. Excessive doses of this drug (≥5 mg/kg) can cause methemoglobinemia and potentially dangerous serotonin toxicity. In rare cases, they may also cause severe anaphylactic shock and cyanide poisoning.

It is therefore recommended to start with the lowest dose (0.5 mg/kg). This means that a 100 kg person might want to begin dosing methylene blue at a 50 mg kg dose. See how your body reacts to the drug. If you need medical attention, immediately contact a healthcare professional.

How to Take Methylene Blue?

Since it’s water-soluble, you can easily take methylene blue with a glass of water. You don’t necessarily have to take this supplement with a meal.

The FDA Drug Safety Communication Department warns against taking methylene blue with serotonergic drugs or antidepressants. Otherwise, high serotonin levels might build up in the brain, causing toxicity. [R]

Methylene Blue Side Effects

Methylene Blue Side Effects

At low doses, methylene blue is generally considered a safe drug.

However, in rare cases, adverse effects may occur. Here are the possible side effects of doing with high amounts of methylene blue:

  • Higher blood pressure
  • Blush-colored lips
  • Confusion
  • Headache
  • Difficulty breaking
  • Dizziness or lightheadedness

Overall, most people experience zero side effects when using this compound. It’s very safe when taken in the right dosages, so just be sure that you don’t take too much and you’ll be fine.

Where to Buy Methylene Blue?

Pure Rawz is the best place to buy Methylene Blue online.

Pure Rawz provides reference materials with every product we sell. All of their products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration. 

Pure Rawz also offers free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin.


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In short, Methylene Blue is a powerful anabolic and nootropic compound with a plethora of benefits, ranging from enhanced mood to better endurance, faster recovery, and much more.

It’s very rapidly growing in popularity, so if you want to get some, it’s best to get some now. We personally think that the Methylene Blue from PureRawz is the purest stuff.

Every batch of their products are 3rd party tested for purity, and they’ve got great deals. Plus, fast shipping, and much more. Just use the code “MD15” and you’ll get a whopping 15% off.

If you have any questions just let us know in the comments section!


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