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Melanotan Review: Benefits, Side Effects, Dosage (2024)

Melanotan Review: Exploring Benefits, Side Effects, and Dosage for a Comprehensive Overview

Melanotan is an analog of alpha-melanocyte stimulating hormone (a-MSH). Alpha-MSH is a naturally produced brain chemical. It is known for stimulating the production and release of melanin, a natural skin pigment that provides pigmentation to your skin, eyes, and hair.

This article will tell you everything you need to know about Melanotan. We’ll kick things off by explaining what this peptide is and how it works in the body. Next, we’ll compare its two forms and discuss their benefits, side effects, and dosages. Read on to know more.

What is Melanotan?

What is Melanotan?

Melanotan is a synthetic peptide with multiple amino acids in its chain. As stated above, it is an analog of the naturally-occurring alpha-MSH. Melanotan can be purchased in the form of nasal sprays or subcutaneous injections from the market without a prescription.

Melanotan is primarily used for skin tanning. It also increases sexual arousal in males and females with sexual dysfunction. Melanotan can promote spontaneous erections in men with organic erectile dysfunction (OED) or psychogenic erectile dysfunction (PED), making it a phenomenal research chemical to pair with something like PT-141 for example.

How does Melanotan Work?

How does Melanotan Work?

Melanotan works by binding to melanocortin receptors (MCRs) in the body. Also known as melanocytes, MCRs are cells in the skin and eyes. These receptors regulate sexual function, pigmentation, and inflammation. There are five melanocytes in the human body.

Different forms of Melanotan (explained below) bind to different MCRs. Melanotan I (MT 1) has a strong affinity for the MC1R and stimulates it to increase the production of melanin. In contrast, Melanotan II (MT-II) binds to three melanocytes (MC1R, MC3R, and MC5R). [R][R]

This is why many bodybuilders choose to combine their SARMs with melanotan as well, because it will help you get nice and tan, so your muscle striations show better and you look extra jacked.

Melanotan 1 Vs Melanotan II

Melanotan 1 Vs Melanotan II

Melanotan comes in two forms: Melanotan 1 and Melanotan II.

Melanotan I can induce tanning and lower blood pressure in healthy adults. It has been in a phase I clinical study as a potential treatment for skin cancer caused by harmful UV rays. Furthermore, the European Commission has approved MT 1 for treating solar urticaria. [R]

Melanotan II has been shown to promote erections in men with erectile dysfunction.

In clinical studies, low doses of this drug induced significant tanning within only 5 days. Preclinical studies have shown that MT-II can cause fat loss without requiring you to watch your diet.

Melanotan 1 Benefits

Melanotan 1 Benefits

Since its initial development in the 1980s, Melanotan 1 has attracted various clinical trials. These human studies have shown that MT1 can cause sunless tanning, reduce high blood pressure (hypertension), and reverse skin damage caused by various skin diseases.

Here are the proven benefits of Melanotan I:

1) Induces skin tanning within days

In a clinical study involving six males and one female, MT 1 treatment (0.16 mg/kg daily) for 14 days induced significant tanning on the face, neck, and forearm. Another trial showed that tanning was achieved after only 10 days. Side effects were mild in both studies. [R][R]

Three phase 1 trials investigated whether this synthetic melanotropic peptide could cause tanning in combination with solar UV rays. Results from the three studies show that MT 1 can be safely combined with sun exposure or UV-B rays to induce skin tanning. [R]

2) Protects against hypertension

Hypertension or high blood pressure kills approximately 10 million people every year. It does that via various diseases, including heart attack, kidney problems, and stroke. [R]

In a preclinical study, Melatonin II protected the subjects against deoxycorticosterone acetate (DOCA)-salt-induced hypertension. These results are highly encouraging because DOCA salt-induced hypertension model has been used to study high blood pressure since the 1970s. [R][R]

3) Approved to treat solar urticaria

Solar urticaria is a rare condition in which rash or hives appear on the skin exposed to the sun. In very few cases, solar urticaria can lead to anaphylaxis, which may kill you.

In July 2009, the European Commission granted MT-1 ‘orphan’ designation for the treatment of solar urticaria in the United Kingdom. The orphan designation is granted to medicines intended to treat a rare condition. It helps save the drugs from competition on the market. [R][R]

4) Clears skin lesions associated with Hailey-Hailey disease

The Hailey-Hailey disease is a rare genetic disorder. It is caused when skin cells fail to stick together and symptoms include blisters and erosions on various body parts.

In a phase II open-label study, MT-II treatment (16 mg/day) for 60 days fully cleared skin lesions caused by Hailey-Hailey disease. What is equally encouraging is that both patients experienced no side effects. Plus, for 8 months after treatment, the disease didn’t recur. [R]

Melanotan 2 Benefits

Melanotan 2 Benefits

Similar to Melanotan I, MT-II has also attracted multiple clinical trials over the years. In these studies, MT-II has shown the potential to stimulate erections in men with ED. MT II has also exhibited the ability to induce sunless tanning and enhance sexual function in males.

Here are the proven benefits of MT II:

1) Stimulates erections in men with ED

According to a double-blind, placebo-controlled study, MT-II injections (0.025 mg/kg of body weight) produced erections in 17 of 20 men with erectile dysfunction. [R]

Two things from this study make one conclude that MT-II can be a potent initiator of penile erection in men with ED. These include its ability to initiate erections on its own (without any sexual stimulation) and the absence of severe side effects. Nausea and yawning were frequently reported.

2) Induces sunless tanning within 2 weeks

In a placebo-controlled crossover study, Melatonin II injections (once every other day for 2 weeks) induced darkened skin in three adult male subjects. [R]

Authors conducting the study recommended dosage of 0.025 mg/kg/day for future studies. They also reported that none of the subjects reported any adverse effects on 6 months of follow-up. Plus, during the study, there was no nausea or decreased appetite.

3) Enhances sexual function in females

Research has shown that MT-II works at the level of the brain to enhance sexual function in females (increased levels of libido and genital arousal). [R]

Unlike other sexual-enhancement drugs, such as Viagra, MT-II doesn’t produce undesirable side effects like increased blood pressure or hypertension. Plus, since it acts on the brain, you don’t need any sexual stimulation for this drug to work.

4) Might cause weight loss

Just as Melanotan I induced fat loss in an animal model, MT-II chronically reduced body mass in animals without the requirements of long-term caloric restriction. [R]

In plain English, that means that MT II is capable of helping you lose weight without forcing you to put an upper limit on your daily caloric intake. Yet, to get the best results out of any weight loss drug, it’s recommended to keep an eye on what you’re eating.

Dosage Information

Melanotan Dosage White Powder on Black Background

Melanotan 1 Dosage

In clinical studies, a 0.25 mg daily dose has been used for sunless tanning. Keep in mind that this (or any other) dosage won’t give immediate results. It may take at least three weeks of administering MT I to see results in the form of darkened skin complexion.

Melanotan 2 Dosage

Different Melanotan 2 dosages have been used in different studies, including:

  • For tanning. 0.025 mg/kg/day
  • For erections. 0.025 mg/kg/day

Frequently Asked Questions

Should you take Melanotan 1 or Melanotan 2?

Given that it’s approved by the European Commission for the treatment of various skin diseases, Melanotan I might be a better option for beginners who haven’t used peptides before.

What are the side effects of Melanotan I?

In multiple clinical studies, Melanotan I has exhibited a fairly tolerable safety profile. Nausea, yawning, and drowsiness were the most frequently reported side effects.

What are the side effects of Melanotan 2?

Mild nausea, not requiring antiemetic treatment, is the most commonly reported adverse effect in Melanotan II studies.

Can Melanotan prevent skin cancers?

Although Melanotan was developed to prevent skin cancer, no clinical research has confirmed that it is capable of preventing skin cancers. Speak to a qualified medical health professional to know more about Melanotan 1 and other prescription medicines.


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Melanotan is a superpotent cyclic melanotropic peptide that increases melanin production in the body. In both its forms, it has been shown to induce sunless tanning, stimulate penile erections in men with erectile dysfunction, and enhance sexual function in women.  

If you’re looking to buy some, we recommend you get the Melanotan for sale from PureRawz, because every batch is 3rd party verified for the utmost purity, and they’re our favorite company that sells it.

Just be sure to use the code “MD15” and you’ll save 15% off your entire order of Melanotan. If you have any questions about this compound, feel free to ask us in the comments section below!


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