The Best Indole 3 Carbinol Tablets Reviewed: Benefits, Dosages, and More (2024)

The quest for effective cancer treatments is indeed a global priority, and researchers worldwide are continually working to discover innovative and more successful approaches to combat this complex set of diseases. While significant progress has been made in recent years with advancements in targeted therapies, finding a universal “miracle” cure for all types of cancer remains a challenge. This article, however, brings you a compound known as Indole 3 Carbinol that has raised eyebrows around the globe for its potential role in cancer prevention.

Introduction

Indole-3-carbinol (I3C) is a compound that is found in vegetables such as broccoli, cabbage, Brussels sprouts, and kale. It is a member of the class of compounds known as indoles, which are naturally occurring chemicals that have been studied for their potential health benefits.

One of the main interests of indole-3-carbinol is its potential role in cancer prevention. It is believed to have anti-cancer properties due to its ability to influence certain pathways in the body. Indole-3-carbinol is a precursor to diindolylmethane (DIM), another compound investigated for its potential health benefits, particularly concerning hormone balance and cancer prevention.

Product Information

Indole 3 Carbinol, also known as indole-3-methanol (C9H9NO), is a naturally occurring compound found in cruciferous vegetables. It carries a hydroxymethyl group at position 3 and has anticancer activity. The compound is a cleavage product of glucobrassicin, a natural compound found in many plant foods, including members of the Cruciferae family. 

It has antioxidant and potential chemopreventive properties and is currently being investigated in clinical trials for its potential in breast cancer prevention. It is found in a variety of organisms, including Picea abies and Pinus sylvestris. {R}

Indole-3-carbinol scavenges free radicals and induces various hepatic cytochrome P450 monooxygenases. Specifically, it induces the hepatic monooxygenase cytochrome P4501A1 (CYP1A1), resulting in increased 2-hydroxylation of estrogens and increased production of the chemoprotective estrogen 2-hydroxyestrone. {R}

Indole 3 Carbinol – How does it work?

Image source: https://en.wikipedia.org/wiki/Indole-3-carbinol

Indole-3-carbinol (I3C) exerts its effects through several mechanisms in the body including:

Estrogen Metabolism: One of the primary mechanisms of action for indole-3-carbinol is its influence on estrogen metabolism. It is metabolized in the body to form diindolylmethane (DIM), which affects the balance of estrogen metabolites. This can be relevant in conditions where estrogen plays a role, such as in hormone-dependent cancers like breast and prostate cancer.

Affecting Signal Transduction Pathways: It influences various signal transduction pathways involved in cell growth and differentiation. This is particularly relevant in the context of cancer prevention, as abnormal cell growth and signaling are hallmarks of cancer development.

Moreover, the compound exhibits antioxidant and anti-inflammatory properties and also supports the body’s detoxification processes, particularly in the liver.

Indole 3 Carbinol- Benefits

There are several potential benefits of indole-3-carbinol:

1. Cancer Prevention:

The latest cancer res has indicated that the compound possesses anti-cancer properties, particularly in hormone-dependent cancers such as breast, prostate, and cervical cancers. It influences various pathways involved in cancer development and may help in preventing the growth of breast cancer cells and prostate cancer cells.

Cancer Epidemiol biomarkers further position it as a subject of interest for identifying and managing breast cancer risk factors. {R}

2. Hormone Balance:

It is known to influence the metabolism of estrogen in the body. It can lead to the formation of diindolylmethane (DIM), which may help balance estrogen levels. This is of interest in conditions where hormonal imbalances may play a role, such as in certain types of cancer or conditions like polycystic ovary syndrome (PCOS). {R}

3. Anti-Inflammatory Properties:

Some studies suggest that it may have anti-inflammatory effects. Chronic inflammation is associated with various health conditions, including cancer and cardiovascular disease. {R}

4. Antioxidant/ Anti-ageing Effects:

Indole-3-carbinol exhibits antioxidant properties, helping to neutralize free radicals in the body. Free radicals can cause oxidative stress, which contributes to aging and diseases.

5. Detoxification Support:

Indole-3-carbinol supports the body’s detoxification processes. It may help the liver metabolize toxins and harmful substances. {R}

6. Weight Management:

Some studies have explored the role of indole-3-carbinol in weight management. It may influence factors related to metabolism and fat storage. {R}

7. Bone Health:

There is some evidence suggesting that it may have a positive impact on bone health by influencing bone turnover and density. {R}

Side Effects

Indole-3-carbinol (I3C) is generally safe when consumed in amounts commonly found in cruciferous vegetables. However, when taken in concentrated supplement form or in larger doses than typically obtained through diet, some individuals may experience side effects such as gastrointestinal distress, dizziness, lightheadedness, or skin rashes in rare cases. 

Moreover, there are some reported cases of its interference with thyroid function, particularly in individuals with existing thyroid disorders, as the supplement enhances liver and thyroid gland neoplastic development.

Legal Status

In the UK, I3C supplements can be legally purchased without a prescription since the European Union, including the UK, categorizes I3C as a food supplement governed by regulations concerning food safety and quality.

In the US, the Food and Drug Administration (FDA) has recognized I3C as a dietary supplement that is available over the counter. The availability of I3C varies globally, however, in most countries, it can be purchased without strict restrictions.

Dosage:

I3C is a dietary supplement that can be purchased without a prescription, either on its own or in combination with other products. The recommended daily dosage ranges between 200 mg and 800 mg.

In a study on breast cancer patients, women were given either a placebo or a daily I3C capsule for four weeks. None of the women experienced any significant toxicity effects.

Where to Buy – Indole 3 Carbinol Supplement

When sourcing supplements online, it’s crucial to select reputable brands to ensure product quality. We’ve partnered with renowned brands, such as Pure Rawz and RCD.Bio is known for its excellence in providing Indole 3 Carbinol. These brands stand out as top choices for several reasons.

PureRawz:

Innovative Formulations: PureRawz is known for its cutting-edge formulations, offering unique and effective supplements.

RCD.Bio:

Premium-Quality Research Chemicals: RCD.Bio is synonymous with premium-quality research chemicals, ensuring that customers receive products of exceptional quality.

Comprehensive Offerings: Both Pure Rawz and RCD.Bio provides Indole 3 Carbinol tablets, offering a comprehensive range of options to cater to diverse preferences.

Reference Materials: Emphasizing transparency, both Pure Rawz and RCD.Bio includes reference materials with every product, providing valuable information for users.

By choosing either Pure Rawz or RCD.Bio, you are opting for trusted suppliers dedicated to delivering high-quality Indole 3 Carbinol tablets, backed by innovation, purity, and transparency.

We recommend Pure Rawz and RCD.Bio is the best place to buy Indole 3 Carbinol. Both RCD.Bio and Pure Rawz provide Indole 3 Carbinol tablets to their online customers.

Conclusion:

In the realm of dietary supplements, I3C has piqued the interest of health enthusiasts and scientists alike. I3C has demonstrated the ability to induce cell cycle arrest (induced cell growth inhibition) in human breast cancer cells. 

The compound’s influence on gene expression provides valuable insights into the molecular intricacies of breast cancer. Moreover, the association between I3C and spontaneous endometrial cancer underscores its potential role in hormonal balance, contributing to our understanding of broader cancer risks. I3C’s dynamic interplay with dietary supplements, cellular processes, and breast cancer risk offers promising avenues for future interventions and preventive strategies.