Hydrafinil Review: Dosage, Benefits, Effects, & More (2022)

Do you struggle to stay alert by the time your workday nears completion? Most people find it hard to shrug off sluggishness after a long day at the office. The good news for all of them – and you – is that Hydrafinil Monophosphate has what it takes to keep you alert.

Research has shown that Hydrafinil not only keeps you from sleep. It also provides you with a well-rested feeling. This helps you stay alert and attentive to your surroundings. You won’t be looking forward to the time you’re again in your bed, ready to doze off.

Hydrafinil boasts serotonergic effects, too. It stabilizes your mood to help you be at your best throughout the day. And the best thing about Hydrafinil is that it exits your system after 6 to 8 hours, so it won’t disturb your sleeping patterns at night.

Intrigued to know more about this supplement? Then you’re at the right place. In this Hydrafinil Monophosphate review, we’ll tell you everything you need to know about this stimulant. Read on if you’ve grown tired of staying tired.

What Is Hydrafinil?

Hydrafinil Liquid Pure Rawz

Hydrafinil, like Flmodafinil, is a metabolite of Modafinil.

When you take modafinil, your body breaks it down into multiple chemicals. These chemicals are ultimately responsible for benefits associated with the drug – improved alertness, cognitive function, and wakefulness . Hydrafinil is one of those chemicals.

Research has proven that Hydrafinil isn’t just another Modafinil derivative. A study on mice found it 39% more powerful than modafinil in promoting wakefulness. And that too over a period of 4 hours, a substantial amount of time given that it amounts to a half working day.

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Further analysis on Hydrafinil led researchers to an exciting conclusion. They have revealed that only one active metabolite of Hydrafinil is responsible for most of its eugeroic (wakefulness and alertness promoting) properties. That metabolite, the researchers suggest, is fluorenol.

Fluorenol is a weak dopamine reuptake inhibitor (increases dopamine levels in the brain), with analysis on fluorenol finding it 39% weaker than modafinil. That is fantastic news. Because it makes fluorenol, and, by extension Hydrafinil, less liable for addiction, one of modafinil’s major side effects.

Overview of Benefits and Effects

In the upcoming sections, we’ll look at what researchers have to say about Hydrafinil. That stuff is going to be pretty technical. To prepare you for it, we’ve decided to give you a quick overview of the benefits and adverse reactions of this nootropic supplement.


  • Promotes Wakefulness
  • Improves Mood
  • Reduces Mental Fatigue
  • Enhances Cognitive Performance
  • Less Addictive Than Modafinil
  • Boosts Mental Clarity

Side Effects

  • Headache
  • Mild Crashing
  • Anxiety
  • Nausea

We’ve heard complaints of dehydration and dry mouth, too.

How Does Hydrafinil Work In The Brain?

how does hydrafinil work in the brain

According to some experts, Hydrafinil has the following mechanisms of action:

1) Increases Dopamine Levels

Hydrafinil prevents dopamine in the central nervous system from being absorbed by the receptors that release it. That’s something Mucuna Pruriens, another nootropic, also does. This enables it to increase dopamine levels, offering you benefits associated with this neurotransmitter. [R]

2) Boosts Choline Concentration

Hydrafinil is an agonist of the 5-HT6 receptor. It stimulates the 5-HT6 receptor to boost the production of choline in the brain. Increased choline levels help increase brainpower and performance. Researchers also link choline to enhanced learning and memory. [R]

3) Enhances Histamine Levels

Both Modafinil and Hydrafinil have this in common. Both these supplements boost wakefulness by enhancing histamine levels in the brain. This is crucial because the histaminergic system promotes alertness. By activating it, modafinil and Hydrafinil help you stay awake. [R]

4) Increases Norepinephrine Levels

Fluorenol does to norepinephrine what Hydrafinil does with dopamine. Fluorenol acts as a norepinephrine reuptake inhibitor (NRI) to prevent the neurotransmitter from going back into the brain cells that released it. Increased norepinephrine levels lead to enhanced cognitive performance. [R]

5) Increases Glutamate Levels

By antagonizing the 5-HT6 receptor, Hydrafinil increases glutamate levels in the brain. This enables it to boost cognitive function and brain health.

Hydrafinil Benefits

hydrafinil benefits

Having looked at what Hydrafinil is and how it works in the brain, it’s time we turn our attention to the amazing benefits that it offers. Unfortunately, the lack of clinical research means we’d have to rely on animal studies and reports on similar substances such as modafinil and Adrafinil.

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Hydrafinil has demonstrated its ability to promote wakefulness in animal studies. Its ability to increase dopamine levels in the brain might help reduce stress levels, too. Anecdotal evidence also links Hydrafinil to increased sex drive and less daytime fatigue.

Here are the major benefits of Hydrafinil:

  • Promotes Wakefulness
  • Improves Mood
  • Reduces Daytime Fatigue
  • Won’t Disrupt Sleep Schedule
  • Less Addictive Than Modafinil

Let’s discuss these benefits.

1) Promotes Wakefulness

Hydrafinil boosts wakefulness by increasing dopamine levels in the brain. Fluorenol, one of its main active metabolites, prevents dopamine from going back to the receptors that release it. This results in an increased level of dopamine in the brain, helping you stay alert for long periods. [R]

By helping you stay alert, Hydrafinil improves decision-making. People who are more aware of their surroundings tend to be better at making choices. That’s because they are more mindful of the factors that could influence the outcome of any decision they’d take.

2) Improves Mood

Anecdotal evidence credits Hydrafinil for improving mood. We believe in such claims because Hydrafinil increases dopamine and serotonin levels in the brain. It does that by acting as a reuptake inhibitor of both inhibitors, preventing them from being re-absorbed.

Research has proven that the increase in serotonin and dopamine levels elevates mood. That’s not all. High serotonin levels boost many cognitive abilities, too, such as memory and learning speed. Increased dopamine levels let you enjoy life more by reducing brain fog. [R] [R]

3) Reduces Daytime Fatigue

There are various anecdotal reports of Hydrafinil reducing daytime fatigue in users. One such statement claims that multiple people experienced reduced fatigue within an hour of taking this drug. If proven by clinical trials, this benefit could prove to be huge. [R]

That is because daytime fatigue is a very common problem. It affects 20% of the US population, estimates the American Academy of Family Physicians. Daytime fatigue increases the risk of work and car accidents, degrades work productivity, and hurts the overall quality of life. [R]

4) Doesn’t Disrupt Sleep Schedule

The same statement that credits Hydrafinil for reducing daytime fatigue claims the nootropic’s wakefulness-promoting effects don’t come at the cost of disruptions in sleep schedule. The user points at the drug’s relatively short half-life to try and substantiate this argument. [R]

Modafinil, which is notorious for disrupting sleep patterns, stays in your system for 13+ hours. This means it will keep you awake for almost the same period. On the contrary, Hydrafinil exits your system after about 6 to 8 hours, potentially taking its effects alongside it.

5) Less Addictive Than Modafinil

Almost all stimulants can be habit-forming drugs, causing addiction over time. Hydrafinil and modafinil aren’t any different. However, while Hydrafinil can be habit-forming, the chances of users getting addicted to this drug are much lower than those getting addicted to modafinil.

The only reason for this is that Hydrafinil is a weaker DRI than Modafinil. Even though this nootropic supplement is 39% more potent than the ‘king of nootropics’. This implies that it won’t increase the dopamine levels to the same point as modafinil, lowering the risk of Hydrafinil addiction.

Hydrafinil Dosage

Users suggest taking 50 mg – 100 mg Hydrafinil daily.

It’s cautioned that the maximum dosage shouldn’t be continued for multiple consecutive days, even if you combine it with a nootropic stack.

Since Hydrafinil is an unregulated drug, there are no official guidelines regarding its dosage. We have suggestions from people who have been using this cognitive enhancer. As such, it’s recommended to consult with your doctor for more accurate dosage requirements.

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As is the case with other nootropic supplements, Hydrafinil could be stacked with other smart drugs. Mainly to potentiate the benefits of this smart drug. Some users suggest stacking it with a choline supplement to keep headaches (one of Hydrafinil’s most common side effects) at bay.

How To Take Hydrafinil?

Hydrafinil is primarily available in three forms: liquid, capsule, and powder.

Hydrafinil liquid is very convenient to take. Your body will absorb the liquid form more rapidly than Hydrafinil contained in capsule form.

The only barrier in the path of powder absorption is your mouth. So mix Hydrafinil powder with a drink (not water), gulp the mixture down, and you’d start feeling the anti anxiety effects of this nootropic.

Hydrafinil Side Effects

Since Hydrafinil isn’t an FDA-approved drug (yet), we don’t have a complete picture of this drug’s entire safety profile. The lack of clinical trials also prevents us from knowing the effects this alternative medicine is capable of causing. For this reason, take caution before using it.

Here are the reported side effects of Hydrafinil:

  • Headache
  • Mild Crash
  • Nervousness
  • Difficulty Sleeping
  • Anxiety And Nausea

Some people have also reported a loss of appetite after using this nootropic. We’ve also heard complaints of dehydration and dry mouth from users who took it for treating depression.

How Hydrafinil Compares With Other Nootropics?

brain abstract

In this section, we’re going to compare Hydrafinil with similar nootropics. Hopefully, our comparison will help you decide whether it’s Hydrafinil – or any other smart drug – that is capable of offering you the desired benefits.

Hydrafinil Vs Modafinil

Even though Hydrafinil is a metabolite of modafinil, there are considerable differences between the two nootropics.

  • Hydrafinil is 39% more potent than modafinil. This means that this supplement’s 150 to 200 mg dose will be as powerful as a 300 to 400 mg dose of modafinil.
  • Hydrafinil is milder than modafinil. Research has shown that it’s a milder dopamine-reuptake inhibitor (DRI) than modafinil, which is why it produces a milder crash.
  • Hydrafinil is less addictive than modafinil. Since it doesn’t increase the dopamine levels as much as modafinil, Hydrafinil is relatively less likely to cause dependence.
  • Modafinil is better studied than Hydrafinil While Hydrafinil hasn’t attracted any clinical trial (yet), tons of human trials and studies support modafinil’s effectiveness.
  • Modafinil is an FDA-approved prescription drug. That isn’t the case with Hydrafinil, which carries the status of an unregulated drug.

Since the last two facts go in its favor, modafinil might be a better option for most people. Even though Hydrafinil has all the attributes to be an all-embracing eugeroic.

Hydrafinil Vs Adrafinil

While both increase dopamine, serotonin, and norepinephrine levels in the brain and aren’t prescription medications, Hydrafinil and Adrafinil have their fair share of differences.

  • Hydrafinil has far fewer severe side effects. Adrafinil has been linked to various severe effects on the liver, as well as orofacial dyskinesia – a condition in which the mouth, face, and tongue move repeatedly and involuntarily. [R]
  • Adrafinil lasts longer in the body. In contrast to Hydrafinil, which has a half-life of 4 to 6 hours, Adrafinil’s half-life stretches to half a day (12 hours). This enables it to last longer in your system than its fellow modafinil metabolite.
  • Hydrafinil is effective in relatively lower doses. Anecdotal evidence indicates that Adrafinil is most effective in 300 to 1,200 mg doses. Hydrafinil, as stated above, can deliver the intended effects in doses of 50 – 150 mg.
  • Adrafinil is water-soluble. You can take it sublingually or mix it in a glass of water. Hydrafinil is insoluble in water.

Keep in mind that Adrafinil was discontinued in 2011. That, and the fact that it might damage the liver, are the reasons why we prefer Hydrafinil over Adrafinil.

Frequently Asked Questions

Where to buy Hydrafinil?

You can buy Hydrafinil powder from Pure Rawz. They provide a 30-day moneyback guarantee, a 100% satisfaction warranty, and ship worldwide. Science Bio also attaches publicly available lab reports to let you verify that the supplement you’re purchasing is safe and effective.

How long does Hydrafinil last?

Hydrafinil doesn’t last long in the system, especially when you compare it with modafinil. It has a half-life of only 6 to 8 hours, compared with 15 hours of modafinil.

Which nootropic improves brain function?

Piracetam has been proven to boost brain function and enhance cognition. It could also reduce negative cognitive symptoms.


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While it doesn’t improve overall brain function like many other nootropics, Hydrafinil offers various health benefits. It boosts mental alertness, elevates mood, and reduces mental fatigue.

This nootropic also reduces daytime fatigue to help you be at your best during working hours.

Aside from that, Hydrafinil has far fewer side effects than Modafinil or Adrafinil. Users claim they don’t experience difficulty sleeping or other adverse symptoms related to the other two nootropics.

This makes it a far safer option, especially for someone who hasn’t used smart drugs before.


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