Do you know that in various studies, peptides have been shown to improve muscle growth and skin health? Research has also shown that peptides may help reduce inflammation and promote injury healing.
Various peptides are available on the market, each offering the benefits mentioned above. One of these is Hexarelin.
Hexarelin is a synthetic peptide that is being studied for its cardioprotective effects and its ability to address growth hormone deficiencies. [2]
What Is Hexarelin?
Hexarelin is a synthetic growth hormone (GH) releasing peptide. It’s a highly selective agonist (provokes a physiological response upon binding to the receptor) of the ghrelin hormone secretagogue. Ghrelin protects against muscle wasting and also increases GH release in the body.
A study has found that Hexarelin increases the release of growth hormone in adults. This enables it to create a more pronounced, leaner muscle tone. That’s because GH is responsible for increasing cell reproduction and regeneration within the muscles. [1]
How Does Hexarelin Work?
Hexarelin, a synthetic growth hormone-releasing peptide, can bind to and activate the growth hormone secretagogue receptor (GHSR) in the brain, similar to its natural analog ghrelin. [2]
However, the peripheral distribution of GHSR in the heart and blood vessels suggests that hexarelin might have direct cardiovascular actions beyond growth hormone release and neuroendocrine effects. [2]
Hexarelin increases the release of growth hormone by enhancing the body’s natural mechanism for triggering its release. This process tells the pituitary gland to increase the release of growth hormones.
Hexarelin also works by blocking a hormone called somatostatin, aka the GH-inhibiting hormone. Somatostatin is responsible for lowering the body’s natural GH output. By limiting the activity of somatostatin, Hexarelin manages to keep GH production elevated.
Hexarelin also binds to the brain’s growth hormone secretagogue receptor. This receptor is responsible for sending signals to the pituitary gland to release growth hormones. After binding to this receptor, Hexarelin activates it and ultimately increases the release of growth hormone.
Potential Benefits of Hexarelin
Following are some of the potential benefits of Hexarelin.
Increases lean muscle growth
Hexarelin stimulates the production of growth hormones, which aids in building lean muscle mass by promoting protein synthesis and muscle repair.
Accelerates weight loss
By boosting metabolism and promoting fat breakdown, Hexarelin helps accelerate weight loss, especially when combined with exercise. [3]
Enhances ligament and tendon strength
Hexarelin supports the regeneration of collagen and other connective tissues, improving the strength and resilience of ligaments and tendons.
Escalates resistance to musculoskeletal injury
By improving muscle strength, joint flexibility, and tissue health, Hexarelin enhances the body’s ability to resist musculoskeletal injuries.
Cardiovascular Protection
Hexarelin offers cardiovascular protection by improving heart function, increasing cardiac output, and promoting vasodilation. [4] It helps lower blood pressure, enhances blood flow, and can potentially protect the heart from damage during stress or injury, contributing to better overall heart health.
Potential Side Effects of Hexarelin
- Induces feelings of tiredness and lethargy
- Excessive dosage might cause numbness
How To Take Hexarelin
Hexarelin can be administered as a subcutaneous injection. This means pricking the needle into the tissue layer between the skin and the muscle.
Users recommend administering a dose of 100 mcg per injection 2-3 times daily. Avoid eating one hour on either side of the dose.
One cycle of Hexarelin lasts 16 weeks (4 months). Take a 4-week break after the completion of the cycle to avoid the adverse effects.
The 1-month break will also enable the next Hexarelin cycle to provide the same benefits as the one before.
Where to Buy Hexarelin?
If you want to purchase this peptide for research purposes, you can order it from any of the following brands. All of these brands hold great reputations among customers.
| Vendor | Rating | Buying Link | Verdict |
| PureRawz | 4.8/5 | Buy Hexarelin from PureRawz | High-quality, trusted vendor |
| Behemoth Labz | 4.7/5 | Buy Hexarelin Acetate from Behemoth Labz | Potent acetate, reputable source |
| RCD Bio | 4.7/5 | Buy Hexarelin Acetate from RCD Bio | Pure peptide, excellent reviews |
| Iron Mountain Labz | 4.6/5 | Buy Hexarelin from Iron Mountain Labz | Reliable product, consistent quality, overall great reputation |
On the Whole
Various studies have shown that Hexarelin increases the production of the natural growth hormone in the body. This enables this peptide to boost lean muscle growth, aid in weight and fat loss, and improve recovery from injuries.
Does Hexarelin Increase Water Retention?
Yes, Hexarelin can cause some water retention due to its effects on growth hormone and IGF-1 levels.
Is Hexarelin Safe?
Hexarelin is generally considered safe but is not FDA-approved. It can be used under medical supervision, but long-term safety data are limited.
Does Hexarelin Increase Muscle?
Yes, Hexarelin can stimulate muscle growth indirectly by increasing growth hormone and IGF-1 levels.
Does Hexarelin Cause Anxiety?
Hexarelin can cause some side effects, like increased cortisol levels, which may contribute to tension or anxiety in some individuals.
Reference Links
- Howard, A. D., Feighner, S. D., Cully, D. F., Arena, J. P., Liberator, P. A., Rosenblum, C. I., Hamelin, M., Hreniuk, D. L., Palyha, O. C., Anderson, J., Paress, P. S., Diaz, C., Chou, M., Liu, K. K., McKee, K. K., Pong, S.-S. ., Chaung, L.-Y. ., Elbrecht, A., Dashkevicz, M., & Heavens, R. (1996). A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release. Science, 273(5277), 974–977. https://doi.org/10.1126/science.273.5277.974
- Mao, Y., Takeshi Tokudome, & Kishimoto, I. (2014). The cardiovascular action of hexarelin. https://doi.org/10.11909/j.issn.1671-5411.2014.03.007
- Mosa, R., Huang, L., Wu, Y., Fung, C., Mallawakankanamalage, O., LeRoith, D., & Chen, C. (2017). Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice. Endocrinology, 158(10), 3174–3187. https://doi.org/10.1210/en.2017-00168
- Noritoshi Nagaya, Miyatake, K., Masaaki Uematsu, Oya, H., Shimizu, W., Hosoda, H., Kojima, M., Nakanishi, N., Mori, H., & Kenji Kangawa. (2001). Hemodynamic, Renal, and Hormonal Effects of Ghrelin Infusion in Patients with Chronic Heart Failure. The Journal of Clinical Endocrinology & Metabolism, 86(12), 5854–5859. https://doi.org/10.1210/jcem.86.12.8115
