Fasoracetam has multiple things going in its favor. Human clinical trials have shown it could treat specific forms of ADHD. Animal studies have linked this nootropic to improvement in cognitive functions. Anecdotal evidence credits it for improving mood, memory, and focus.
Even the US Food and Drug Administration is keen on the drug. In 2015, the FDA gave Fasoracetam developers the green light to use this drug in human clinical trials. It was in one of those trials where this nootropic showed it could be a potential treatment for ADHD.
Two things could happen from now onwards. Fasoracetam could prove its efficacy in clinical trials and earn approval by the FDA. Or it could show limited efficacy and join a long list of drugs that showed huge potential at first but proved to be a bust in the long run.
Human trials, animal studies, and anecdotal evidence suggest that the first scenario is more likely to happen. That optimism is one of the reasons why we have come up with this Fasoracetam review. Read on to know more about this nootropic.
What is Fasoracetam?
Fasoracetam, like piracetam, belongs to the racetam family of nootropics. It was developed by a Japanese pharmaceutical company as a treatment of vascular dementia. But when the drug proved to be ineffective, its producer washed its hands off it.
Recognizing the drug’s potential, NeuroFix, a US-based firm, rescued Fasoracetam. It purchased all the clinical research from its manufacturer. That decision was later on justified when human clinical trials showed that Fasoracetam could treat specific forms of ADHD.
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Thirty 12 – 17-year-olds were enlisted for the trial. All of them had the same specific form of ADHD. After undergoing Fasoracetam treatment for 5 weeks, every single one of the teenagers experienced significant improvements in their condition, raising this smart drug’s reputation. [R]
Since then, more Fasoracetam benefits have come to the fore. Animal studies have shown that this nootropic could improve cognitive functions. Anecdotal evidence backs up these findings. It also links Fasoracetam to improvements in mood, memory, and focus and concentration.
Is Fasoracetam legal?
Fasoracetam’s legal status varies based on the country you’re living in:
- Is Fasoracetam legal in the US? Fasoracetam carries the status of research chemical in the United States. You can buy, use and possess it for study or scientific purposes without needing a prescription.
- Is Fasoracetam legal in Australia? Fasoracetam is a schedule 4 substance in Australia. Schedule 4 substances are available in pharmacies around the country. You can buy Fasoracetam by producing a prescription.
Firacetam hasn’t earned FDA approval yet.
How Does Fasoracetam Work In The Brain?
Fasoracetam works in the following ways:
1) Increases Acetylcholine Levels
Fasoracetam stimulates the uptake (absorption) of choline in the brain’s hippocampus and cortex regions, which in turn increases acetylcholine levels. Acetylcholine is a neurotransmitter that plays a crucial role in learning, memory, and other cognitive functions. [R]
Acetylcholine’s functions aren’t limited to the brain. It also contracts smooth muscles, expand blood vessels and slows heart rate.
2) Modulates Glutamate Receptors
Glutamate is one of the major neurotransmitters in the central nervous system. Glutamate receptors are crucial for memory formation, neural communication, and learning. Low glutamate levels might give way to attention deficit hyperactivity disorder, depression, and other mental disorders.
Fasoracetam helps prevent all these neurological disorders by triggering glutamate receptors and modulating their interactions with other receptors in the central nervous system.
3) Increases Release of GABA (B)
Gamma Aminobutyric Acid (GABA) is an inhibiting neurotransmitter. It works by blocking brain signals and slowing down activity in the nervous system. Researchers have found that GABA induces a calming effect, watering down feelings of stress, anxiety, and fear.
By stimulating the release of GABA B, together with the modulation of glutamate receptors, Fasoracetam increases motivation and eases depression and anxiety symptoms.
Fasoracetam Benefits
The benefits of Fasoracetam aren’t limited to ADHD patients. This nootropic could also treat depression and anxiety, boost memory, concentration and focus, and improve mood. Users also report they feel calmer and less anxious after taking Fasoracetam powder.
Here are the benefits of Fasoracetam:
- Potential ADHD Treatment
- Boosts Memory And Learning
- Improves Concentration And Focus
- Eases Depression And Anxiety Symptoms
- Prevents Learned Helplessness
Let’s discuss these benefits in detail.
1) Potential ADHD Treatment
There are seven different types of ADHD. Fasoracetam might treat the specific ADHD type caused by mutations in the metabotropic glutamate receptors (mGluR). This type of attention deficit hyperactivity disorder represents up to 10% of total ADHD cases. [R]
A 5-week, placebo-controlled study found Fasoracetam successfully easing ADHD symptoms in thirty 12 – 17 year olds. All the study’s participants were given up to 400 mg of this nootropic. All of them experienced ‘significant’ improvement in their condition at the trial’s conclusion. [R]
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What is even more encouraging is that Fasoracetam was well-tolerated. All the adverse events were mild in nature and required no treatment. And researchers were able to find no link between the adverse events and Fasoracetam, meaning the drug is probably safe for use.
2) Reverses Memory Disruption
Memory disruption, or amnesia, is very rare disease among older adults. A report claims that almost 2% people in the US are diagnosed with it each year. Brain injuries, brain diseases, brain infections, cardiac arrest and anoxia (lack of oxygen) are among amnesia’s most common causes. [R]
Animal studies have shown that Fasoracetam could reverse amnesia. This smart drug was administered to rats facing memory loss due to various artificial causes. Its performance was then compared against various other nootropics in two different tasks of passive avoidance response.
Researchers found that Fasoracetam reversed amnesia by stimulating the release of acetylcholine in the cerebral cortex. Acetylcholine is a neurotransmitter linked with memory. Fasoracetam increased its release by stimulating high-affinity choline uptake. [R]
3) May Improve Focus and Concentration
Although there is no documented research on the effects of Fasoracetam on focus and concentration, anecdotal evidence suggests that this nootropic can make you more attentive. The reason why we take such claims seriously is because of acetylcholine.
As stated above, Fasoracetam stimulates the release of this neurotransmitter. That is relevant because acetylene enhances attentional focus. Researchers have found that this brain chemical increases your attention span by modulating neural activity through various brain regions. [R]
To get the best results, you might want to stack Fasoracetam with Aniracetam. Various studies suggest that Aniracetam increases your concentration by stimulating acetylcholine release in the brain. Taken with Fasoracetam, which works similarly, this nootropic might doubly-boost your focus.
4) May Improve Cognition
Researchers have connected the dots between acetylcholine and cognitive function. This brain chemical successfully targets various brain regions associated with learning, thinking, problem solving, decision-making and reasoning. That’s why all the best nootropics target acetylcholine.
Fasoracetam does the same. In one animal study, this cognition enhancer stimulated high-affinity choline uptake to increase acetylcholine levels in the brain. While the study in question didn’t observe the effects of acetylcholine on cognition, we can tap other pieces of research to understand the same.
Various studies have shown that when compared with their healthy counterparts, Alzheimer’s disease patients have low levels of cortical acetylcholine. For this reason, researchers now believe that the decline in acetylcholine is to blame for cognition-impairment and various types of dementia. [R]
5) May Ease Anxiety and Depression Symptoms
Have you heard about mood-influencing chemicals? Or, to be more precise, about the two brain chemicals that influence your mood more than most of the others put together? To break the suspense, we’re talking about glutamate and gamma-aminobutyric acid (GABA) here.
Anyone who reads relevant research literature knows that one thing is common between multiple mood disorders and bipolar disorder. That is disturbance in the glutamergic system. Similar is the case with GABA, whose low levels are standard in people with depression. [R] [R]
That Fasoracetam increases one (GABA) and inhibits the other (glutamate) probably explains why users credit it for improving mood. It also explains why, in animal studies, rats who took Fasoracetam were less prone to show depression symptoms in stressful situations. [R]
6) May Alleviate Withdrawal Symptoms
Drug withdrawal is a serious health condition. It might combine physical, emotional, and mental symptoms to harm the quality of life. When joined with other co-existing health conditions, such as high blood-pressure, diabetes, or depression, drug withdrawal can be deadly. [R]
Clinical data reveals that GABA indirectly causes withdrawal symptoms. When you’re on a drug, this brain chemical increases dopamine levels in the brain, creating a craving for the drug. The high dopamine levels linger on even when you’ve stopped taking the drug, causing withdrawal symptoms. [R]
Fasoracetam might address this issue by ensuring normal functioning of the GABA receptors. This is especially useful for Phenibut users. Anecdotal evidence indicates that Phenibut causes withdrawal symptoms, something you can avoid by taking Fasoracetam.
7) Prevents Learned Helplessness
Learned helplessness is when an individual feels nothing they could do will change their situation. For instance, an addict may repeatedly try and fail to get rid of their addiction. He might grow frustrated and believe that things aren’t in his control, and thus stop trying altogether.
Psychologists insist that learned helplessness could lead to feelings of depression. It could also cause PTSD and other health conditions. If you feel you have a pessimistic attitude towards life, consider cognitive behavioral therapy, though Fasoracetam might also help. [R]
Animal studies have shown that Fasoracetam could protect you from developing learned helplessness. Rats who were administered this nootropic tried repeatedly to complete the task, not letting multiple failures get in the way of them trying to finish the job. [R]
Fasoracetam Dosage
There aren’t any official Fasoracetam dosage guidelines.
In the earlier mentioned ADHD trial, thirty 12 – 17 year olds received 50 – 800 mg single dose at first. The participants were then given 400 mg Fasoracetam per day for 4 weeks. The researchers observed that all the side effects were mild in nature, showing that the drug was well-tolerated.
Since it’s highly potent, many Fasoracetam users suggest taking 40 mg daily (in one or two doses) will help you get the desired effects. If you want to be on the safe side, it’s suggested that you take 20 mg daily for the first one or two weeks of using this nootropic drug.
Here are user-recommended Fasoracetam dosage guidelines:
- For beginners: 20 mg per day
- For experienced nootropic users: 40 mg per day
Because it is water soluble, you can take Fasoracetam without a meal. Some users even suggest taking it sublingually (under the tongue), suggesting that it works quickly that way. However, since this drug is highly bitter, we suggest you take it with water.
Lastly, evidence available from ADHD trials show that Fasoracetam is highly unlikely to cause dependence. Even if you take high doses. Still, to be on the safe side, stop using this drug for a week after completing one cycle, before restarting again.
How to take Fasoracetam?
Fasoracetam is commonly available in three forms: capsule, powder and solution.
It’s suggested you buy and use Fasoracetam solution. Solution-form of any drug takes less long to work than capsules or tablets. You could also mix Fasoracetam solution with water and gulp it down.
The body will be able to quickly absorb its ingredients than if it was in drug form.
Take care not to stack this drug with Phenibut.
According to reports, an individual lost consciousness after taking 500 mg Phenibut (three times daily) with 50 – 100 mg Fasoracetam (once a day) for only two days. Fortunately, the medics were able to stabilize his condition in the hospital. [R]
Fasoracetam Side Effects
Many human trials involving Fasoracetam are ongoing. At the time of writing, results from only one human study are available. Participants of the above-mentioned ADHD trial experienced only mild side effects, even though they were taking 400 mg per day.
This shows that Fasoracetam might not cause any severe effects, even at high doses. But to be on the side safe, we suggest you stick to the dosage guidelines suggested above (20mg or 40 mg per day). The risk of developing dependence with this nootropic is also minimal.
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Having said that, as with other racetams, some users may experience fleeting and mild side effects. These might include:
- Fatigue
- Headache
- Stomach Pain
Most of these symptoms will occur due to the way Fasoracetam works. This nootropic increases the release of choline in your brain, something which can offset by stacking it with a choline supplement. Our recommendation for a choline supplement is Alpha GPC.
There are a few categories of people who shouldn’t use this drug. Or, just as they do with other drugs, consult their doctor before taking Fasoracetam. These include persons with impaired kidney function, breastfeeding, pregnant or nursing women.
Fasoracetam Stacks
Stacking Fasoracetam with other drugs will offer two benefits.
First, since it is a potentiator like other racetams, Fasoracetam could enhance the effects of any other nootropic you decide to mix it with.
Second, this nootropic might cause mild headaches in some users, a side-effect you can easily avoid by stacking it with a choline supplement.
1) Fasoracetam + Choline + Noopept
Do you want to improve your cognitive functions and mental alertness? Then this could be the perfect stack for you. Fasoracetam and Noopept are well-known for enhancing brain functions. Adding choline to the mix, meanwhile, will reenergize you, while also keeping headaches at bay,
To get optimal results, kick off your day with 500 mg of choline and 10 mg of Noopept and Fasoracetam with breakfast. Complete the daily stack with a dose of 10 mg Noopept in the evening.
2) Fasoracetam + Coluracetam
Fasoracetam and Coluracetam are both racetams. Their similar chemical structure allows them to potentiate each other’s effects. Fasoracetam offers all the benefits mentioned above, while Coluracetam improves your vision, aside from offering various other benefits.
For the best results, take 10 mg Fasoracetam and 10 mg Coluracetam once or twice a day. If you experience headache, add a choline supplement to this stack.
Frequently Asked Questions
Fasoracetam takes only 2 – 4 hours to start working in the body. Fasoracetam powder delivers the intended effects much quickly than capsule or tablets. That’s because it’s easy for the body to absorb capsules than the drug in encapsulated form.
Fasoracetam has been used in clinical trials as a potential treatment of ADHD. Users also rely on this racetam nootropic to boost cognitive functions, improve memory and ease the symptoms of anxiety and depression, even in the absence of any human studies.
Fasoracetam is water soluble. This differentiates it from a few other racetams, namely Aniracetam, Pramiracetam, and Phenylpiracetam, all of which are fat-soluble.
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Conclusion
Fasoracetam offers you multiple reasons to give it a try. This racetam has shown promise in human trials that it could effectively treat ADHD. Animal studies, meanwhile, have shown that it could reduce anxiety and depression, possibly in humans too.
It isn’t only the benefits that go in this drug’s favor. Fasoracetam’s safety profile, too, increases its reputation. In the ADHD trials, all the participants who took this drug experienced no severe side effects. That is a rarity for such a powerful nootropic.
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Little wonder, then, anecdotal evidence is so overwhelmingly in its favor. Users claim that Fasoracetam increases cognition functions, improves memory and takes away the feelings of learned helplessness. They also credit it for improving their mood.
Sure, this drug cause a few side effects, but you can count most of them with a choline supplement. All in all, then, one can say that Fasoracetam is effective as well as safe. And one would have both anecdotal and scientific evidence to back this claim.
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