Enclomiphene is an estrogen receptor modulator that raises the levels of testosterone, follicle-stimulating hormone, and luteinizing hormone in the body. This enables it to increase sperm count in men, treat ovarian dysfunction in women, and induce fertility in both sexes.
All these effects are why Enclomiphene is a potential treatment for female infertility. It might also be effective for male hypogonadism, a condition in which the body doesn’t produce enough testosterone or sperm. If untreated, it can lead to infertility or erectile dysfunction.
However, while most people are aware of these effects of Enclomiphene, they don’t know that this drug can also help you put on lean body mass. The majority of its users also erroneously mistake Enclomiphene for clomiphene, an FDA-approved treatment for female infertility.
To help you become more knowledgeable about Enclomiphene, we have come up with this guide. In the following paragraphs, we’ll discuss this drug’s benefits, working mechanism, and side effects. Plus, we’ll reveal the dosages at which Enclomiphene is safe and effective.
What is Enclomiphene?
Enclomiphene is a selective estrogen receptor modulator (SERM). SERMs are medications that mimic and block estrogen’s effects in different tissues, making them great for a SARMs post cycle therapy.
Different SERMs are currently being used as a treatment for breast cancer, osteoporosis, and postmenopausal symptoms, but bodybuilders use it as post cycle therapy & to get rid of gyno. [R]
Enclomiphene blocks the activity of estrogen receptors in the body. Aside from that, it raises the levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Enclomiphene can also increase your testosterone levels while keeping your sperm count intact. [R]
This makes it a potential treatment for infertility in males and females. Its effects also make Enclomiphene a promising candidate for treating hypogonadism in men. Both infertility and hypogonadism are characterized by reduced testosterone and/or sperm levels. [R]
Enclomiphene has also been found to increase lean body mass (LBM) in men. This shouldn’t come as a surprise as this drug can increase testosterone production – various studies have drawn a direct line between raised testosterone levels and increased LBM. [R]
How does Enclomiphene Work?
In humans, Enclomiphene has been shown to:
- Block estrogen from binding to receptors in the hypothalamus. This, in turn, decreases the effectiveness of the estrogen receptor and prevents it from inducing the desired effects in the body. [R]
- Increase gonadotropin release in the anterior pituitary. Gonadotropins are peptide hormones that regulate ovarian and testicular function. They are essential for normal growth and sexual development. [R]
The above effects induce different hormonal changes in both sexes. In men, they result in increased testicular stimulation and serum testosterone levels via increased LH and FSH production. In women, the above effects lead to ovulation. [R][R]
Enclomiphene Vs Clomiphene
Enclomiphene and clomiphene are selective estrogen receptor modulators, similar to SARMs. Both have been shown to modulate estrogen receptor activity in humans, mice, and other animal species. In clinical studies, both SERMs reportedly increased testosterone, FSH, and LH levels.
Here are three major differences between Enclomiphene and clomiphene:
- Enclomiphene is a single isomer, while clomiphene citrate consists of a mixture of isomers. Zuclomiphene, a weak estrogen receptor agonist, is another isomer of clomiphene citrate. [R]
- Enclomiphene is an estrogen antagonist, whereas clomiphene can agonize or antagonize estrogen depending on the target tissue. This makes clomiphene much more versatile than its isomer. [R]
- Enclomiphene isn’t FDA-approved. Clomiphene has been an FDA-approved drug to treat female infertility since 2006.
Enclomiphene Vs TRT
Enclomiphene and testosterone replacement therapy (TRT) have been proven to increase men’s T, FSH, and LH levels. However, while TRT is clinically used to treat male hypogonadism, Enclomiphene has yet to earn the nod of the US Food and Drug Administration.
Which is surprising given that Enclomiphene holds various advantages over TRT, such as: [R]
- It doesn’t suppress sperm levels
- It doesn’t suppress the testicular function
- It doesn’t pose a transference risk
- It doesn’t cause testicular atrophy
Enclomiphene Benefits
Enclomiphene is one of the few unapproved drugs with clinical trials backing its effects. This means you don’t have to rely on anybody’s word to believe Enclomiphene works. Various human studies show that this drug is safe as well as effective.
Here are the proven benefits of Enclomiphene:
1) Stimulates testosterone production
Multiple clinical trials report that Enclomiphene could increase serum testosterone levels.
In a randomized phase 2 clinical trial, Enclomiphene citrate stimulated testosterone production while preventing oligospermia (low sperm count). The increase in serum testosterone levels was similar to those obtained with a topical testosterone gel in men with secondary hypogonadism. [R]
Another study showed that when combined with diet and exercise, oral Enclomiphene citrate produced a 61.5% increase in total testosterone values compared to a 28.2% increase with a placebo. The study involved men between the ages of 18 and 60 years. [R]
2) Maintains or increases sperm count
While many drugs can increase testosterone production, they may also hurt sperm production in the process. Fortunately, Enclomiphene is different.
A phase 2 clinical trial has shown that this drug can give you the best of both worlds – increase testosterone levels while maintaining sperm count in the normal range. This means that you can count on Enclomiphene to keep oligospermia at bay for the most part. [R]
Another study reported that oral Enclomiphene citrate increased sperm counts in men with low testosterone. This distinguishes this drug from other sources of exogenous testosterone, which lower sperm count and thus increase the risk of infertility. [R]
3) Might treat secondary hypogonadism
Male hypogonadism is a condition in which the body doesn’t produce enough levels of testosterone or sperm, or both. If untreated, it can lead to infertility or erectile dysfunction.
According to a clinical study, Enclomiphene can be used to treat some men with secondary hypogonadism, especially the one caused by dysfunctional but reversible hypothalamus/pituitary activity. Such men present with low T, FSH, and LH levels. [R]
Another study recommends Enclomiphene to treat testosterone deficiency in men for whom testosterone therapy is not suitable. That is because Enclomiphene can increase T levels by raising LH and FSH levels, without negatively impacting semen parameters. [R]
4) Might be beneficial for female infertility
As noted above, Clomiphene is an FDA-approved treatment for female infertility.
A 2013 double-blind study investigated and compared the effects of clomiphene and Enclomiphene treatment in women with unexplained infertility. The same doses (100 mg) of both drugs were administered to females enrolled in the study. [R]
Final results indicated that the total number of mature follicles (a key indicator of fertility) was significantly higher in the Enclomiphene group. Furthermore, there was no statistically significant difference in the clinical pregnancy rate in both groups. [R]
5) Increases lean body mass
An increased lean body mass helps fight obesity, lowers your risk of multiple diseases, and helps in the development of strong bones.
In a clinical study involving men with secondary hypogonadism, Enclomiphene citrate, in combination with diet and exercise, significantly improved lean body mass. In contrast, the study’s participants who were on a placebo lost lean mass. [R]
This is why Enclomiphene is often used after a particularly harsh testosterone repressing cycle of SARMs like RAD 140 or Ligandrol. It’s great at helping you keep your gains after your cycle, and getting testosterone production back up at the same time.
Enclomiphene Dosage
In clinical trials, 12.5 mg to 25 mg Enclomiphene citrate significantly increased testosterone levels in normal men, with the 12.5 mg dose superior to the 6.25 mg dose in terms of bringing the men’s testosterone levels into the mid-normal range. [R]
That being said, the dosage will depend a lot on your current estrogen levels, testosterone levels, what your cycle is, and/or was in the past, and many other things. In general however, 20mg/day for 60 days is the approved dosage that bodybuilders agree on.
Enclomiphene Side Effects
Enclomiphene appears to be well-tolerated with few adverse effects. The phase II/III trials of this drug have reported relatively mild side effects, such as elevated estradiol levels, headache, and abdominal discomfort. However, this drug’s long-term effects remain unknown. [R]
I’ve personally never experienced any side effects when using this drug, and I’ve taken it many times after different SARMs cycles (like the first time I took Ostarine and Cardarine combined). Some people may experience side effects, but in my experience it is very rare.
Conclusion
Enclomiphene is a selective estrogen receptor modulator that could increase testosterone levels, maintain sperm count, and help males put on lean muscle mass. It also has an excellent safety profile and delivers the best effects at a daily dose of 12.5 mg – 25 mg.
In summary, it’s a great drug to use after your cycle to get your testosterone back up and keep your gains, but you can also use it on cycle to avoid estrogen getting too high, and even just to boost testosterone in general as an alternative to TRT (although long-term use isn’t advised).
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❓ Is Enclomiphene FDA-Approved?
While several clinical trials verify its safety and efficacy, enclomiphene is yet to be approved by the FDA or any regulatory agency in the world.
❓ What is the half-life of enclomiphene?
Enclomiphene has a half-life of 10 hours.
❓ Is enclomiphene the same as Clomid?
Enclomiphene is one of two isomers of Clomid, the other being zuclomiphene. Unlike Clomid, which is an agonist/antagonist of estrogen receptor, enclomiphene only antagonizes the ER in humans.
❓ Does enclomiphene raise testosterone levels?
Yes. Various studies have reported that enclomiphene citrate treatment raises free, total, and serum testosterone levels in humans. That, too, without hurting sperm production.
❓ Is enclomiphene a steroid?
No. Enclomiphene belongs to the class of selective estrogen receptor modulators (SERMs). SERMS are drugs that mimic and block estrogen's effects in different tissues.
