BPC 157 Full Guide: Review, Dosage, Benefits & More (2021)
BPC 157 is a synthetic peptide supplement. Peptide supplements are sold all over the world and are being investigated for their ability to build muscle, shed fat, and boost weight. Some users claim they could help with muscle recovery, just like steroids. BPC 157 could apparently do all that and more.
However, as is the case with most supplements, BPC 157 also has its fair share of side effects. The gravity of which is directly proportional to this peptide supplement’s dosage, which is why you’d do well to be moderate in your intake of this supplement.
In this article, we’re going to talk about what BPC 157 is, how it works and the dosage that might be ideal (and safe) for you. We’ll also discuss this peptide supplement’s side effects, how you can avoid them while taking it all the same, and how you can administer this drug.
That’s not all. Most of you who have heard of BPC 157 might also have caught the murmurings of how you can take this drug orally and administer it via an intramuscular injection. We’ll look at both these approaches to decide which of the two is better for you.
What Is BPC 157?
BPC 157, short for ‘body protection compound’, is a synthetic pentapdecapeptide. This means it’s a peptide and is made up of a chain of 15 amino acids. BPC 157 is derived from human gastric juice, which is to say that it’s already in your body, albeit in a different sequence.
Various studies have been conducted on BPC 157 to analyze its benefits. Most of them seemed to have reached one conclusion: BPC 157 is great for the body. It has been found to repair broken bones and joints, heal stomach ulcers and cure damaged intestines.
Aside from that, it can reverse the damage done to the organs, fight inflammation inside the body, and reduce the risk of brain disease. Studies on experimental rat models have also established that BPC 157 boosts collagen production to allegedly protect your skin against aging.
That’s where the good news ends. As the United States Anti-Doping Agency notes in its BPC 157 paper, there are yet to be any clinical trials or studies that show this supplement is safe (or even effective) in humans. All the benefits linked to it have been established via animal trials. [R]
Overview of Benefits & Effects
Before we focus our attentions on what research has to say about BPC 157, let’s have a brief glance at the benefits and drawbacks of this highly-effective supplement.
- Boosts Wound Healing
- Strengthens The Heart
- Reduces Knee and Joints Pain
- Counteracts Toxicity by NSAIDs
Research is still ongoing to highlight the full extent of this research peptide’s drawbacks. However, if anecdotal evidence is to be believed, BPC 157’s side effects are fairly mild
Is BPC-157 legal?
BPC-157 is legal to use in the US, though you can only purchase it via a prescription. This synthetic peptide supplement is not on the World Anti-Doping Agency (WADA) Prohibited List, which means athletes may also take it to improve their health and quickly recover from injury.
Not much information is available about whether BPC 157 is legal in Europe, though. Users in Australia, meanwhile, may purchase it with a prescription as the supplement isn’t banned in the country. Remember that BPC-157 is a research peptide and hasn’t been approved for use by humans (yet).
How Does BPC 157 Work?
BPC 157 works by triggering the formation of new blood vessels in a process called angiogenesis. It allegedly does that by increasing the formation of the vascular endothelial growth factor. VEGF is a signaling protein whose primary function is to give birth to new vessels. [R]
This allows BPC 157 to heal the inflamed gut lining. It also enables it to block a specific molecule (known as 4-hydroxynonenal) from inhibiting the healing of tendons. This, in turn, might make tendon cells more receptive to growth signaling molecules, helping tendons heal quickly.
BPC 157 might also help body wounds heal quickly by boosting the health of the endothelium, a fragile membrane that lines the inside of blood vessels and the heart. The resulting improvements in the health of endothelium might allow BPC 157 to offer cardio-protective benefits, too.
Lastly, research carried on rat aorta has found BPC 157 improving the production of nitric oxide in the body, great news as nitric oxide causes the blood vessels to widen. In this way, BPC 157, by increasing the formation of nitric oxide, might lower blood pressure and increase blood flow. [R]
Benefits of BPC 157
Body Protection Compound 157 has been shown to provide various benefits. It can allegedly promote wound healing, cure ulcers in the stomach and repair intestinal damage caused by inflammatory disorders and fistulas. You may also count on it to help you with pain and depression.
All these benefits of BPC 157 have been established by animal trials. Studies conducted on humans, meanwhile, have linked this peptide supplement to a reduction in knee pain, healing of the gastrointestinal tract and counteracts toxicity caused by NSAIDs.
Here are the various benefits of BPC 157:
- Boosts Wound Healing
- Strengthens Your Heart
- Reduces Knee Pain
- Heals The GI Tract
- Fights Toxins in the Body
Now, let’s look a little bit deeper at each of these benefits, and examine the supporting research.
1. Boosts Wound Healing
Researchers have found that new blood vessels are essential for wound healing. Wound injuries end up damaging the blood vessels in the body. This prevents their tissues from receiving the supply of much-needed oxygen. This cut-off in oxygen supply causes the tissues to swell, and they start to die. [R]
BPC 157 throws the damaged tissues a lifeline by triggering the formation of new blood vessels via a process known as angiogenesis (discussed in detail above). These new blood vessels supply oxygen-rich blood to the tissues, helping them recover. The rejuvenated tissues then help the wound heal.
2. Strengthens Your Heart
There are many ways you could strengthen your heart. You could take a 10-minute walk whenever you’re free. Stick to a daily diet that includes one extra vegetable or fruit. Or take a few deep breaths whenever you’ve a few seconds of free time. Or you could just take the recommended dose of BPC 157. [R]
Here’s why we’re saying that. It’s an open secret that BPC 157 increases the production of nitric oxide (NO) in the body. Most people are aware of this fact. What the majority doesn’t know, sadly, is that NO causes blood vessels to dilate (expand), reducing blood pressure and boosting cardiovascular health.
3. Reduces Knee Pain
According to a study on adults with knee pain, about 92% (or 11 of the 12) who were given BPC 157 as an intra-articular injection experienced significant improvement in knee pain. The study’s results were impressive not only because BPC 157 was shown to relieve almost all types of knee pain. [R]
Instead, its results caught the public’s eye because a potential cure was found for a problem affecting almost every US household. A study by US CDC found that 1 in every 4 American adults had one or the other type of knee pain in 2020, a number that amounts to around 15 million. [R]
4. Helps Heal the Gastrointestinal Tract
According to a study carried out by more than a dozen researchers from multiple universities and organizations across the globe, BPC 157, by improving ligament, bone and tendon healing, can help heal the gastrointestinal tract much better than other peptides such as EGF, VEGF and FGF. [R]
This shouldn’t come as a surprise to you if you were paying attention by now. We have already mentioned various studies stating how BPC 157 triggers the formation of blood vessels to help heal damaged skin tissues. Guess what? The peptide supplement takes the same route to heal the gastrointestinal tract.
5. Counteracts Toxicity by NSAIDs
Make no mistake about it. Non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, are lifesavers for millions of people worldwide. Apart from reducing pain, these drugs help lower fevers, reduce inflammation and keep blood from clotting. Little wonder, then, that they are uber popular.
Unfortunately, NSAIDs can also be toxic for some people, with symptoms including headache, dizziness, and blurred vision, among others. Scientists are aware of NSAIDs’ potential to cause toxicity, but it was only in 2019 that they found a substance – BPC 157 – that might be the perfect antidote to NSAIDs. [R]
BPC 157 Dosage and Cycle Guidelines
Although you can orally ingest BPC 157 or administer it via an injection, most anecdotal evidence of BPC 157 dosage comes from users who have or are currently injecting this supplement. These users insist that that BPC 157’s dosage ranges between 1-10mcg per kilogram of your body weight.
Here are the ideal dosages of BPC-157:
- If you weigh 70 kg, you might want to inject 70 – 700 mcg of BPC 157
- If you weigh 80 kg, you might want to inject 80 – 800 mcg of BPC 157
- If you weigh 90 kg, you might want to inject 80 – 800 mcg of BPC 157
How to choose whether to stick with the lower or higher end of the dosage? The best way to decide is by consulting with your doctor. They’re aware of your medical history, the list of supplements you (might be taking) at this time and your current condition. So they’re the best person to recommend.
Keep in mind that one BPC 157 cycle ranges between 6 and 12 weeks, with the lower end of the range more than ideal for beginners. Once you’ve completed the cycle, we suggest you turn to post cycle therapy to help your body restart its testosterone production.
How To Administer BPC 157?
There are two ways you can administer BPC 157:
- Orally: The capsule, pill, or spray forms of BPC 157 are ideal for people dealing with intestinal and stomach issues. Another upside to this approach is that it’s more convenient for most people, especially those who aren’t comfortable with needles.
- Injection: You might want to inject BPC 157 if you’re dealing with inflammation, knee pain, muscle sprains, and ligament damage. You can either insert the injection into your muscle. Or you can stick its needle into the lump of skin covering the pained muscle.
Provided you decide to inject BPC 157, make sure you’re doing so on an empty stomach. Also, if you’re taking more than a single dose per day (one dose per day is more than enough for most people), make sure to spread the injections at least four hours apart.
BPC 157 Side Effects
Most reported side effects of BPC 157 tend to be mild. This shouldn’t come as a surprise given that this peptide is derived from a synthetic source, human gastric juice. Having said that, research is ongoing on BPC 157. So we cannot expect to know all the side effects of this supplement.
Here are the reported side effects of BPC 157:
- Redness/swelling at the injection site
Make sure you consult with your doctor before you start taking this supplement. Not because it isn’t safe or anything like that. Many supplements, whether taken orally or administered via an injection, can interact with any medicine you might be already taking. So talking with your doctor before you start taking BPC 157 is recommended.
The US Federal Drug Authority might not have approved BPC 157. But that has more to do with the lack of human trials than the safety of this supplement. Had that not been the case, and BPC 157 wasn’t safe for human use, various researchers wouldn’t have conducted human studies with this supplement.
These studies show that BPC 157 boosts wound healing and heals the gastrointestinal tract by triggering the formation of new blood vessels in the body. It’s also a fact that this peptide strengthens your heart, reduces knee pain and is an antidote to NSAIDs.
Sure, this supplement has its fair share of side effects, but a mere glance at the list of risks should make it clear that most of them are mild or moderate. The high-risk side effects exist, but only if you don’t follow the dosage guidelines suggested by experts and verified by anecdotal evidence.
All of this is to say that BPC 157 is safe, effective and efficient. As long as you aren’t an athlete or are going to compete in a national or international sports competition, or you’ve some medical condition discouraging the use of this supplement, we see no reason why you shouldn’t use BPC 15.