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Myostatin Guide – Benefits, Side Effects, Dosage, and More

Myostatin Guide

Athletes and bodybuilders hate Myostatin. This hormone inhibits skeletal muscle growth, making it difficult to put on lean muscle mass and lose body fat. For this reason, anyone who wants to get muscular should do everything possible to inhibit this hormone.

Inhibition of myostatin won’t just increase the size of your muscles. Research has shown that it may also prevent bone loss and reduce the risk of fractures. Plus, if your myostatin levels are at the lower end of their normal range, you’ll be at a lower risk for obesity.

All in all, whether you want to be muscular or are worried about the expanding circumference of your waistline, myostatin inhibition should be on top of your to-do list. But that is easier said than done, given the proliferation of myostatin-inhibiting drugs out there.

Luckily, we’re here to help. Apart from discussing myostatin and the health benefits of inhibiting this hormone, we’ll reveal one of the best myostatin-inhibiting supplements. This article will also inform you of the dosage at which the supplement will work at its best.

What is Myostatin?

Myostatin is a hormone naturally produced in the body. It negatively regulates muscle growth and development to help your muscles retain their strength. This means that if your body has zero myostatin, your muscles won’t be able to generate any force.

Research has shown that your myostatin levels are at their lowest at birth and increase as you age. During embryonic development (when the child is still in the womb), Myostatin determines how many muscle fibers an individual will eventually have in their life.

However, as crucial as this hormone is, excess of everything is bad. Research has shown that having too much myostatin may hurt muscle growth and strength. This condition, caused by a mutation in the myostatin gene, may also cause bone issues and joint issues

Some individuals with this condition may experience trouble breathing, moving, and walking. This condition may sometimes lead to joint deformities, heart problems, and other issues. It is thus essential that your myostatin levels remain in a normal range.

How does Myostatin Work?

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Myostatin binds to receptors on muscle cells and signals them to stop growing and dividing. This helps to maintain skeletal muscle mass and limits muscle growth to prevent a condition known as gross muscle hypertrophy. It also enables muscles to retain their strength.

However, myostatin alone doesn’t regulate muscle growth and strength. Research has shown that this hormone interplays with the insulin-like growth factor 1 (IGF-1)/ phosphatidylinositol 3-kinase/Akt pathway responsible for an increase in protein synthesis. [R]

While normal levels of myostatin are necessary for your health, increased myostatin expression (due to could hurt muscle growth. Myostatin mutation and the subsequent elevation in this hormone’s levels have also been found in the devilment of cancer, HIV, and kidney disease [R]

How do Myostatin Inhibitors Work?

Myostatin inhibitors work by blocking the action of this hormone. This supplement prevents myostatin from binding to activin receptors in muscle cells. This results in reduced expression of Myostatin in the body, increasing the size of skeletal muscle tissue.

In addition to preventing this hormone from doing its job, myostatin inhibitors also block the action of other members of the transforming growth factor-B (TGF-B) family, of which this hormone is a member. This enables these drugs to stimulate muscle growth further.

Some individuals with myostatin-related muscle hypertrophy may experience trouble breathing, moving, and walking. This condition may sometimes lead to heart problems and kidney disease. It is thus essential that your myostatin levels remain in a normal range. [R]

Benefits of Inhibiting Myostatin

Multiple preclinical and clinical studies have shown that Myostatin doesn’t just help stimulate an increase in muscle mass. The best myostatin inhibitors can also prevent your muscles from degenerating, both due to long periods of inactivity as well as disease

You could also experience decreased fat mass by supplementing this drug. Research has indicated that dosing with myostatin inhibitors could reduce the accumulation of fat mass in the body, thanks to the reduction in the size of adipocytes (fat-storing cells).

Increased bone mineral density is another benefit of decreased myostatin levels. Bone mineral density determines how much calcium and other types of minerals are in a specific area of your bone. Low BMD can lead to severe medical conditions, including osteoporosis.

Here are the proven benefits of inhibiting Myostatin:

1)   Increased Muscle Mass

Various studies have shown that low myostatin levels equal higher muscle growth.

One of the studies involved a human child with high levels of muscle development. On further investigation, it was revealed that the child had low levels of Myostatin. [R]

A pilot study confirmed this finding by reporting that healthy adult subjects had increased muscle mass after seven days of treatment with a myostatin inhibitor. [R]

2)   Reduced Risk of Muscle Degeneration

Myostatin inhibitors could prevent muscle degeneration caused by:

  • Long periods of inactivity [R]
  • Chronic kidney disease [R]
  • Skin and lung cancer [R]
  • Huntington’s disease [R]
  • Duchenne Muscular Dystrophy [R]

Myostatin inhibitors’ ability to prevent muscle loss during long periods of inactivity should interest athletes and bodybuilders who cannot work out for an extended period. As studies show that your muscle size can decrease by up to 11% after just 10 days without lifting weights. [R]

3)   Decreased Body Fat

Myostatin inhibitors can also help reduce body fat.

These supplements treat the cause (size of fat-storing cells), not the symptoms of high body fat. They reduce the size of adipocytes to make sure that much of the energy you consume ends up in muscle cells, thereby organically promoting fat loss. [R]

In fact, there are not one but three natural ways using which myostatin inhibitors lower body fat. These include improved glucose metabolism (quick burning of carbohydrates), increased insulin sensitivity, and metabolic changes in skeletal muscles. [R]

4)   Improved Bone Mineral Density

Increased BMD can significantly improve your quality of life.

Think of strengthened bones, reduced risk of fractures, and lower chances of developing osteoporosis and other medical conditions affecting your bones. All these benefits can be acquired by increasing your bone mineral density.

Which is precisely what myostatin inhibitors do. A 2020 study has shown that targeting Myostatin and the receptors significantly increased bone mineral density. [R]

5)   Better Heart Health

Myostatin inhibitors may indirectly improve heart health.

These supplements have been proven to increase muscle mass, which, in turn, has been found to have beneficial effects on heart function. Having more muscle mass can increase oxygen uptake and cardiovascular function, contributing to a stronger and more efficient heart.

Another way increased muscle mass can improve heart health is by keeping body fat levels low, which has been proven to lower the risk of heart disease.

Myostatin Inhibition Results

Results from a clinical study suggest that myostatin inhibitors led to an increase in thigh volume in healthy participants without causing any side effects

Anecdotal evidence indicates that inhibiting this hormone produced ‘sustained decreases in fat mass’ and ‘subsequent increases in muscle mass’.

One user, in particular, noted that the ‘strength and size of his thigh muscle’ experienced a significant boost after dosing this supplement for six months.

Myostatin Dosage

How much Myostatin you should take per day depends on your fitness-related goals.

Clinical trials have shown that Myostatin dosages that prevented muscle loss in older adults were different from those that increased muscle mass in healthy adults.

Similarly, in studies investigating the potential fat-burning effects of this supplement, lower dosages were used than in the above clinical trials.

Here are the myostatin dosages that have been proven to give results:

  • For muscle building: 100 to 300 mcg a day (2 to 4 weeks)
  • For fat loss: 10 mcg a day + low-fat diet + exercise (1 to 3 months)

How to Take Myostatin Inhibitors?

Inject the myostatin inhibitor directly into the specific muscle you’d like to boost.

Keep in mind that myostatin has low oral bioavailability, meaning it won’t be absorbed by the bloodstream if taken through the mouth. Regularly change injection sites to reduce the risk of irritation, skin redness, and rashness.

Where to buy Myostatin Inhibitors?

Pure Rawz is the best place to buy Myostatin inhibitor online.

Pure Rawz provides reference materials with every product we sell. All of their products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration. 

Pure Rawz also offers free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin.

Myostatin Inhibitors Side Effects

One possible risk of myostatin inhibitors is the increased risk of muscle injury due to the added stress these supplements may palace on the muscle fibers.

You may also experience irritation, rashes, and redness at the injection site.

In rare cases, the following side effects may occur, such as:

  • Tendon rupture due to excessive muscle growth
  • Increased risk of muscle strains and injuries
  • Possible risk of heart problems
  • Potentially adverse effects on kidney health


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Myostatin inhibitors help you build muscle mass by inhibiting the action of the enzyme that limits muscle growth and prevents muscles from getting too large.

These supplements also help you retain the muscle you have already built, not letting long periods of inactivity or disease induce muscle atrophy.

It has also been shown that they can stimulate fat burning, improve heart health, and enhance bone mineral density. All in all, you can count on myostatin inhibitors to help you achieve a muscular body with less body fat and overall improved health.


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